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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | Dairy consumption, obesity and the insulin resistance syndrome in young adults显示文摘 | PEREIRA M A JACOBS D R VAN HORM L | 2002 | Journal of American Medicine Association2002，287，： | 2 |
| 3 | Hepatic phosphatidylethanolamine N-methyltransferase,unexpected roles in animal biochemistry and physiology显示文摘 | LI Z JACOBS R L | 2007 | J Biol Chem2007，282，33： | 1 |
| 4 | Identifi- cation and subtyping of Francisella by pyrosequencing and signature matching of 16S rDNA fragments 显示文摘 | Jacob D Wahab T Edvinsson B Peterzon A Boskani T Farhadi L Barduhn A Grunow R Sandstrom G | 2011 | Lett Appl Microbiol2011，53，6： | 1 |
| 5 | Submucosal purse-string suture as a treatment of leakage around the indwelling voice prosthesis显示文摘 | JACOBS K DELAERE P R VANDER POORTEN V L | 2008 | Head Neck2008，30，： | 1 |
| 6 | Assessing manag- ers' ethical decision-making: An objective measure of managerial moral judgment显示文摘 | Loviscky G E Trevifio L K Jacobs R R | 2007 | Journal of Business Ethics2007，73，3： | 1 |
| 7 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 8 | Environmentally acceptable specialty lubricantsan interpretation of the environmental regulations of North Sea(world)显示文摘 | Stringfellow W D Jacobs N L Hendriks R V | 1993 | NLGI Spokesman1993，57，9： | 1 |
| 9 | Electro transport processes in conductor-filled polymers显示文摘 | Shermen R D Middleman L M Jacobs M | 1983 | Polymer Engineering and Science1983，23，1： | 1 |
| 10 | Phylogeneticsof Panicoideae (Poaceae) based on chloroplast and nuclear DNAsequences 显示文摘 | Teerawatananon A Jacobs S W L Hodkinson T R | 2011 | Telopea2011，13，11： | 1 |
| 11 | Dietary fat and incidence of type 2 diabetes in older women显示文摘 | Meyer K A Jacobs D R Kushi L H | 2011 | Diabetes Care2011，24，2： | 1 |
| 12 | Relationship of MIC to efficacy of cefotaxime in treatment of Streptoooccus pneumoniae infections 显示文摘 | Kaplan S L Schutze G E | 1996 | Antimicrob Agents Chemother1996，40，： | 1 |
| 13 | Effect of streptozotocin-induced diabetes and of insulin treatment on homocysteine metabolism in the rat 显示文摘 | Jacobs R L House J D Brosnan M E | 1998 | Diabetes1998，47，12： | 1 |
| 14 | Inhibition of cytolytic T lymphocyte proliferation by autologous CD4+/CD25+ regulatory T cells in a colorectal carcinoma patient is mediated by transforming growth factor-beta显示文摘 | Jacob L Swoboda R | 2002 | Cancer Res2002，62，18： | 1 |
| 15 | Software strategies for portable computer energy management 显示文摘 | Jacob R L Alan J S | 1998 | IEEE Personal Communications1998，5，3： | 1 |
| 16 | Homocysteine as arisk factor for ischem icstroke: an epidem iological story in evolution 显示文摘 | SACCO R L ROBERTS J K JACOBS B S | 1998 | Neuroepidemiology1998，17，4： | 1 |
| 17 | Type IV secretion system is not involved in infection process in citrus 显示文摘 | Jacob T R Laia M L Moreira L M | 2014 | International Journal of Microbiology2014，，： | 1 |
| 18 | A Software Model and Specification Language for Non-WIMP User Interfaces 显示文摘 | Jacob R J K L Deligiannidis | 1999 | ACM Transactions on Computer-Human Interaction1999，6，1： | 1 |
| 19 | Interaction of ammonia with Brnsted acid sites in different cages of zeolite Y as studied by proton MAS NMR显示文摘 | JACOBS W DE HAAN J VAN DE VEN L VAN SANTEN R | 1993 | J Phys Chem1993，97，10： | 1 |
| 20 | Types of tech- nological scanning in manufacturing SMEs: an empirical analy- sis of patterns and determinants 显示文摘 | JULIEN P A RAYMOND L JACOB R | 1999 | Entrepreneurship & Re- gional Development1999，11，4： | 1 |
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