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| 1 | Australian tertiary care outcomes of entecavir monotherapy in treatment naive patients with chronic hepatitis B显示文摘AIM:To evaluate the long-term treatment outcomes of entecavir monotherapy in treatment naive patients in an Australian tertiary care setting. METHODS:A retrospective analysis of treatment naive patients receiving entecavir monotherapy through Westmead Hospital was performed.Patients were excluded if they had received previous treatment with another nucleoside or nucleotide analogue,were pregnant or less than 18 years old. RESULTS:Out of 336 patients,163 patients fulfilled the selection criteria.Range of follow up was 3-46 mo (mean 26 mo).134 patients(82.2%)had pre-treatment biopsies,with 26 patients(16.0%)demonstrating F3-4 fibrosis.In total,153 patients(93.9%)achieved at least Partial Virological Suppression(PVS),with 134 patients (82.2%)achieving complete virological suppression. The cumulative CVS and PVS rates at 36 mo were 82.1%and 96.4%,respectively.3 patients(1.8%)failed to achieve PVS,while 5 patients(3.0%)developed virological rebound.128 patients(78.5%)maintained CVS throughout follow up.Predictors of CVS included lower baseline DNA level(P=0.001),hepatitis B virus e antigen negative status(P=0.001)and increasing age at treatment(log rank 0.001).No significant adverse effects were reported necessitating cessation of entecavir. CONCLUSION:Entecavir monotherapy is efficacious and safe in an Australian tertiary care setting.Resistance and rebound rates are very low.This is similar to data from controlled and uncontrolled trials around the world. | Farzan Fahrtash-Bahin Viraj C Kariyawasam Timothy Gray Karen Byth Jacob George Mark W Douglas | 2013 | World Journal of Gastroenterology2013，19，5： | 5 |
| 2 | Which Time-to-Peak Threshold Best Identifies Penumbral Flow?: A Comparison of Perfusion-Weighted Magnetic Resonance Imaging and Positron Emission Tomography in Acute Ischemic Stroke显示文摘 | J Sobesky O Zaro Weber F -G. Lehnhardt V Hesselmann A Thiel C Dohmen A Jacobs M Neveling W -D. Heiss | 2004 | Stroke2004，，12： | 2 |
| 3 | Insulin resistance is associated with chronic hepatitis C and virus infection fibrosis progression显示文摘 | Jason M Hui Archana Sud Geoffrey C Farrell Priyanka Bandara Karen Byth James G Kench Geoffrey W McCaughan Jacob George | 2003 | Gastroenterology2003，，6： | 2 |
| 4 | Mesh Saliency显示文摘 | LEE C H VARSHNEY A JACOBS D W | 2005 | ACM Transaction on Graph2005，24，3： | 1 |
| 5 | Mesh Saliency 显示文摘 | Lee C H Varshney A Jacobs D W | 2005 | ACM Transaction on Graph2005，24，3： | 1 |
| 6 | Identification, purification, and characterization of a thiol-activated hemolysin(suilysin) of Streptococcus suis 显示文摘 | JACOBS A A C LOEFFEN P L W BERG A J G | 1994 | Infect Immun1994，62，5： | 1 |
| 7 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 8 | Verbal exchange structure of initial medical interviews显示文摘 | Stiles W B MaDaniel S H Jacob M C | 1982 | Health Psychology1982，1，： | 1 |
| 9 | Homoclinic chaos in systems perturbed by weak Langevin noise显示文摘 | Bulsara A R Schieve W C Jacobs E W | 1990 | Phys Rev1990，41，： | 1 |
| 10 | Decreased phagocytosis of apoptotic cells in diseased SLE mice 显示文摘 | LICHT R DIEKER J W JACOBS C W | 2004 | J Autoimmun2004，22，2： | 1 |
| 11 | Ebselen,a selenium- containing redox drug,releases zinc from metallothionein显示文摘 | Jacob C Mater W Vallee BL | 1998 | Biochem- Biophys -Res - Commun1998，，3： | 1 |
| 12 | Endophytic fungi in indigenous Australian grasses associated with toxicity to livestock显示文摘 | Miles C O di Menna M E Jacob S W L | 1998 | Applied and Environmental Microbiology1998，64，： | 1 |
| 13 | Atomic-scale insight into the interactions between hydroxyl radicals and DNA in solution using the ReaxFF reactive force field 显示文摘 | VERLACKT C C W NEYTS E C JACOB T | 2015 | New Journal of Physics2015，17，10： | 1 |
| 14 | Mesh Saliency显示文摘 | C H Lee A Varshney D W Jacobs | | 0，，03： | 1 |
| 15 | New evidence for a relation between wind stress and wave age from measurements during ASGAMAGE显示文摘 | OOST W A KOMEN G J JACOBS C M J | 2002 | Bound-layer meteor2002，103，3： | 1 |
| 16 | The E3L gene of vaccinia virus encodes an inhibitor of the interferon-induced,double-stranded RNA-dependent protein kinase显示文摘 | CHANG H W WASTON J C JACOBS B L | 1992 | PNAS1992，89，11： | 1 |
| 17 | Fusion for low-gradeadult isthmic spondylolisthesis:a systematic review of the literature显示文摘 | Jacobs W C Vreeling A De Kleuver M | 2006 | Eur Spine J2006，15，4： | 1 |
| 18 | Joining ceramic composites using active Metal/HPCS preceramic polymer slurries显示文摘 | Sherwood W J Whitmarsh C K Jacobs J M | 1997 | Ceramic Engineering Science Proceeding1997，18，： | 1 |
| 19 | An in situ Fourier transform infrared studyof zeolitic vibrations: Dehydration, deammoniation, and reammoniation of ion-exchanged Y zeolites显示文摘 | JACOBS W P J H VAN WOLPUT J H M C VAN SANTEN R A | 1993 | Zeolites1993，13，3： | 1 |
| 20 | Influence of annealing on the pasting properties of starches from varying botanical sources显示文摘 | Jacobs H Eerlingen R C Clauwaert W et ol | 1995 | Cereal Chem1995，72，： | 1 |
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