|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | Light-induced fluorescence studies on dehydration on incipient enamel lesions显示文摘 | A1-Khateeb S Exterkate R de Josselin de Jong E | 2002 | Caries Res2002，36，： | 1 |
| 3 | The double-sliding,free-rotating model for granular assemblies显示文摘 | De Josselin De Jong G | | 0，，02： | 1 |
| 4 | Incidental langerhans cell histiocytosis of thyroid : case report and review of the literature显示文摘 | FOULET-ROG A JOSSELIN N GUYETANT S | 2002 | Endocr Pathol2002，13，： | 1 |
| 5 | Application of the calculus of variations to the vertical cut-off in cohesive frictionless soil显示文摘 | De Jong De Josselin G | 1980 | Geotechnique1980，30，1： | 1 |
| 6 | Optimal wavelet transform for the detection of microaneurysms in retina photographs显示文摘 | QUELLEC G LAMARD M JOSSELIN P M | | 0，，09： | 1 |
| 7 | Infliximab efficacy and safety against refractory systemic necrotising vasculitides:long-term follow-up of 15 patients显示文摘 | Josselin L Mahr A Cohen P | 2008 | Ann Rheum Dis2008，67，9： | 1 |
| 8 | Strategies for improving the assessment of dental fluorosis:focus on optical techniques显示文摘 | A ngmar-Mansson B de Josselin de JE Sundstrom F | 1994 | Adv Dent Res1994，8，1： | 1 |
| 9 | Capacitive detection scheme for space accelerometers applications显示文摘 | Josselin V Touboul P Kielbasa R | 1999 | Sensors and Actuators1999，，： | 1 |
| 10 | Capacitive detection scheme for space accelerometers applications显示文摘 | JOSSELIN V TOUBOUL KIELBASA R | 1999 | Sensors and Actuators1999，78，： | 1 |
| 11 | Bone microarchitecture in males with corticosteroid-induced osteoporosis显示文摘 | Chappard D Josselin N Rouge-Maillart C | 2007 | Osteoporosis Int2007，18，： | 1 |
| 12 | Photoelastic verification of mechanical model for the flow of a granular material显示文摘 | Drecher A De Josselin de Jong G | 1972 | Journal of mechanical physics of solids1972，20，5： | 1 |
| 13 | Inertial Sensor Concept for the Gravity Wave Missions 显示文摘 | Josselin V Rodrigues M Touboul P | 2001 | Acta Astronautica2001，49，2： | 1 |
| 14 | A new method for in vivo quantification of changes in initial enamel caries with laser fluorescence显示文摘 | de Josselin de Jong E Sundstrom F Westerling H | 1995 | Caries Res1995，29，1： | 1 |
| 15 | Quanlitative light-induced fluorescence(QLF) : A tool for early occlusal dental caries detection and supporting decision making in vivo显示文摘 | Alammari MR Smith PW de Josselin de Jong E | 2013 | J Dent2013，41，2： | 1 |
| 16 | Capacitive detection scheme for space accelerometers application 显示文摘 | JOSSELIN V TOUBOUL P KIELBASA R | 1999 | Sens and Actuat A: Phys1999，78，23： | 1 |
| 17 | Singularity analysis of closed-loop kin- ematic chains 显示文摘 | Josselin C Angeles J | 1990 | IEEEJ Robot Autom1990，6，3： | 1 |
| 18 | A longitudinal laser fluorescence study of white spot lesions in orthodontic patients显示文摘 | AL-KHATEEB S FORSBERG C M JOSSELIN | | 0，，06： | 1 |
| 19 | The double sliding, free rotating model for granular assemblies 显示文摘 | De Josselin de Jong G | 1971 | Geotechnique1971，，21： | 1 |
| 20 | Capacitive detection scheme for space accelerometers applications 显示文摘 | Josselin V Touboul P Kielbasa R | 1999 | Sansors and Actuators1999，7，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员