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| 1 | Hematological disorders and pulmonary hypertension显示文摘Pulmonary hypertension(PH),a serious disorder with a high morbidity and mortality rate,is known to occur in a number of unrelated systemic diseases.Several hematological disorders such as sickle cell disease,thalassemia and myeloproliferative diseases develop PH which worsens the prognosis.Associated oxidant injury and vascular inflammation cause endothelial damage and dysfunction.Pulmonary vascular endothelial damage/dysfunction is an early event in PH resulting in the loss of vascular reactivity,activation of proliferative and antiapoptotic pathways leading to vascular remodeling,elevated pulmonary artery pressure,right ventricular hypertrophy and premature death.Hemolysis observed in hematological disorders leads to free hemoglobin which rapidly scavenges nitric oxide(NO),limiting its bioavailability,and leading to endothelial dysfunction.In addition,hemolysis releases arginase into the circulation which converts L-arginine to ornithine,thus bypassing NO production.Furthermore,treatments for hematological disorders such as immunosuppressive therapy,splenectomy,bone marrow transplantation,and radiation have been shown to contribute to the development of PH.Recent studies have shown deregulated iron homeostasis in patients with cardiopulmonary diseases including pulmonary arterial hypertension(PAH).Several studies have reported low iron levels in patients with idiopathic PAH,and iron deficiency is an important risk factor.This article reviews PH associated with hematological disorders and its mechanism:and iron homeostasis and its relevance to PH. | Rajamma Mathew Jing Huang Joseph M Wu John T Fallon Michael H Gewitz | 2016 | World Journal of Cardiology2016，8，12： | 6 |
| 2 | Effect of closure of live poultry markets on poultry-to-person transmission of avian influenza A H7N9 virus: an ecological study显示文摘 | Hongjie Yu Joseph T Wu Benjamin J Cowling Qiaohong Liao Vicky J Fang Sheng Zhou Peng Wu Hang Zhou Eric H Y Lau Danhuai Guo Michael Y Ni Zhibin Peng Luzhao Feng Hui Jiang Huiming Luo Qun Li Zijian Feng Yu Wang Weizhong Yang Gabriel M Leung | 2013 | The Lancet2013，，： | 2 |
| 3 | 查看详情显示文摘 | T H Douglas A C Joseph | | 0，，： | 1 |
| 4 | Preferred risk allocation in target cost contracts in con- struction显示文摘 | Joseph H L Chan Daniel W M Chan Patrick T I Lam | 2011 | Facilities2011，29，1314： | 1 |
| 5 | Corporate Ownership Structure and the Informativeness of Accounting Earnings in East Asia显示文摘 | Joseph P H Fan T J Wong | 2002 | Journal of Accounting and Economics2002，，33： | 1 |
| 6 | Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer Jaagsiekte virus显示文摘 | JOSEPH H T JASON H KAKAJAN K | 2010 | PNAS2010，107，15： | 1 |
| 7 | P-type electrical conduction in ZnO thin films by Ga and N codop- ing显示文摘 | joseph M Tabata H Kawai T | 1999 | Jpn J Appl Phys1999，38，： | 1 |
| 8 | Effect of surfactant addition on phenanthrene biodegradation in sediments显示文摘 | Harry J T Joseph B H Michelle T J | 1995 | Environ Toxicol Chem1995，14，6： | 1 |
| 9 | Corporate ownership and the informative ness of accounting earnings显示文摘 | Fan Joseph P H T J Wong | 2002 | Journal of Accounting and Economics2002，33，： | 1 |
| 10 | Dynamic response of layered structures subject to blast effects of non-nuclear weaponry显示文摘 | JOHN R H DAVID J R | 1987 | Computers and Structures1987，26，12： | 1 |
| 11 | Baseline mean and heterogenei- ty of MR cartilage T2 are associated with morphologie degeneration of cartilage, meniscus, and bone marrow over 3 years--data from the Osteoarthritis Initiative 显示文摘 | Joseph GB Baum T Alizai H | 2012 | Osteoarthritis Cartilage2012，20，： | 1 |
| 12 | Politically connected CEOs, corporate governance, and post-IPO performance of China's newly partially privatized firms显示文摘 | Joseph P H Fan T Wang J and Tianyu Zhang | 2007 | Journal of Financial Economics2007，84，2： | 1 |
| 13 | Reaction kinetics and optimization of the copper-catalyzed oxidation of ApoA-1M 显示文摘 | Sa V H Joseph K M Kristen E T | 2009 | Chemical Engineering Science2009，64，： | 1 |
| 14 | Corporate Ownership Structure and the Informativeness of Accounting Earnings in East Asia 显示文摘 | Fan Joseph P H Wong T J | 2002 | Journal of Accounting and Economics2002，33，3： | 1 |
| 15 | Development of human protein reference database as an initial platform for approaching systems biology in humans 显示文摘 | PERI S NAVARRO J D AMANCHY R KRISTIANSEN T Z JONNALAGADDA C K SURENDRANATH V NIRAN JAN V MUTHUSAMY B GANDHI T K GRONBORG M IBARROLA N DESHPANDE N SHANKER K SHIVASHANKAR H N RASHMI B P RAMYA M A ZHAO Z CHANDRIKA K N PADMA N HARSHA H C YATISH A J KAVITHA M P MENEZES M CHOUDHURY D R SURESH S GHOSH N SARAVANA R CHANDRAN S KRISHNA S JoY M ANAND S K MADAVAN V JOSEPH A WONG G W SCHIEMANN W P CONSTANTINESCU S N HUANG L KHOSRAVI-FAR R STEEN H TEWARI M GHAFFARI S BLOBE G C DANG C V GARCIA J G PEVSNER J JENSEN O N ROEPSTORFF P DESHPANDE K S CHINNAIYAN A M HAMOSH A CHAKRAVARTI A PANDEY A | 2003 | Genome Research2003，13，10： | 1 |
| 16 | 显示文摘 | Joseph M Tabata H Kawai T | 1999 | Applied Physics Letter1999，74，： | 1 |
| 17 | Corporate Ownership Structure and the Informativeness of Accounting Earnings显示文摘 | Joseph P H Fan T J Wong | 2002 | Journal of Accounting and Economics2002，，33： | 1 |
| 18 | Utilization of fish processing by products in the gelatin industry显示文摘 | Joseph W Jian T Gu X H | 2007 | Food Reviews International2007，23，2： | 1 |
| 19 | Do External Auditors Perform a Corporate Governance Role in Emerging Markets Evidence from East Asia 显示文摘 | Fan Joseph P H T J Wong | 2005 | Journal of Accounting Research2005，43，1： | 1 |
| 20 | Effect of High-Q Ba4Til3030 Materials on the dielectric properties of (Bax,Sr1-x)TiO3 films for microwave communication 显示文摘 | CHENG H F JOSEPH P T LEE Y C | 2007 | Electromagn Waves and Appl2007，21，： | 1 |
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