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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Antidiabetic and antioxidant effects of Annona muricata (Annonaceae), aqueous extract on streptozotocin-induced diabetic rats显示文摘 | Ngueguim Tsofack Florence Massa Zibi Benoit Kouamouo Jonas Tchuidjang Alexandra Dzeufiet Djomeni Paul Désiré Kamtchouing Pierre Dimo Théophile | 2014 | Journal of Ethnopharmacology2014，，2： | 2 |
| 3 | Development of ferrite rolling textures in low and extra low-carbon steels显示文摘 | Toth L S Jonas I J Daniel D | 1990 | Metallurgical Transactions1990，21，4： | 1 |
| 4 | Spreadsheet Modelling of Grain Size Evolution During Rod Rolling 显示文摘 | Maeeagno T M Jonas J J Hodgson P D | 1996 | ISIJ International1996，36，6： | 1 |
| 5 | Poly (3,4-ethylenedioxythiophene) and its derivatives:Past,present,and future显示文摘 | Groenendaal B L Jonas F Freitag D | 2000 | Adv Mater2000，12，： | 1 |
| 6 | 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial显示文摘 | Ian Smith Marion Procter Richard D Gelber Sébastien Guillaume Andrea Feyereislova Mitch Dowsett Aron Goldhirsch Michael Untch Gabriella Mariani Jose Baselga Manfred Kaufmann David Cameron Richard Bell Jonas Bergh Robert Coleman Andrew Wardley Nadia Harbec | 2007 | The Lancet2007，，9555： | 1 |
| 7 | Empowering project portfolio managers: How management involvement impacts project portfolio management performance 显示文摘 | Jonas D | 2010 | Interna- tional Journal of Project Management2010，28，8： | 1 |
| 8 | Natural phospholipase A2 myotoxin inhibitor proteins from snakes,mammals and plants显示文摘 | Sergio L Gilberto D Jonas P | | 0，，： | 1 |
| 9 | Evaluation of the mecA femB duplex polymerase chain reaction for detection of methicillin-resistant Staphylococcus aureus显示文摘 | Jonas D Grundmann H Hartung D | 1999 | Eur J Clin Microbiol Infect Dis1999，18，9： | 1 |
| 10 | 显示文摘 | Groenend B L Jonas F Freitage D | 2000 | Adv Mater2000，12，： | 1 |
| 11 | Clinical trial of lamivudine in children with chronic hepatitis B显示文摘 | Jonas M M Kelley D A Mizerski J | 2002 | N Engl J Med2002，346，22： | 1 |
| 12 | Perioperative effects of alpha-stat versus pH-stat strategies for deep hypothermic cardiopulmonary bypass in infants显示文摘 | du Plessis AJ Jonas RA Wypij D | 1997 | J Thorac Cardiovasc Surg1997，114，6： | 1 |
| 13 | Spreadsheet Modelling of Grain Size Evolution During Rod Rolling显示文摘 | Maccagno T M Jonas J J Hodgson P D | 1996 | ISIJ Inter national1996，36，6： | 1 |
| 14 | Design of a surveillance system of antibiotic use and bacterial resistance in German intensivecare units(SARI)显示文摘 | Meyer E Jonas D Schwab F | 2003 | Infection2003，31，4： | 1 |
| 15 | Current issues in recrystallization:a review显示文摘 | DOHERTY R D HUGHES D A HUMPHREYS F J JONAS J J JENSEN D J KASSNER M E KING W E MCNELLEY T R MCQUEEN H J ROLLETT A D | 1997 | Materials Science and Engineering A1997，238，1： | 1 |
| 16 | Study of peroxide metabolism enzymes during the development of Phaseolus vulgris 显示文摘 | SIMON L FATRAI M Z JONAS D E | 1974 | Biochem Physiol1974，166，： | 1 |
| 17 | 显示文摘 | Groenendal B L Jonas F Freitage D | 2004 | Adv Mater2004，12，： | 1 |
| 18 | 显示文摘 | Groenendaal L Jonas F Freitag D | 2000 | Adv Mater2000，12，： | 1 |
| 19 | Flow and dipole source evaluation of a genericSLV显示文摘 | JONAS A LARS D | 2011 | Journal of Fluids Engineering2011，132，5： | 1 |
| 20 | Evaluation of the rnecA femB duplex polymerase chain reaction for detection of methiciliin resistant Staphylococcus aureus 显示文摘 | Jonas D Grundmann H Hartung D | 1999 | Eur J Chn Microbiol Infect Dis1999，18，9： | 1 |
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