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128篇 您的检索式：作者名="JIRTLE"

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	题名	作者	年代	出处	被引量
1	Clinical significance of loss of heterozygosity for M6P/IGF2R in patients with primary hepatocellular carcinoma显示文摘AIM:To investigate the relationship between loss of heterozygosity (LOH) for mannose 6-phosphate/insulin- like growth factor 2 receptor (M6P/IGF2R) and the outcomes for primary HCC patients treated with partial hepatectomy. METHODS: The LOH for M6P/IGF2R in primary HCC patients was assessed using six different gene-specific nucleotide polymorphisms. The patients studied were enrolled to undergo partial hepatectomy. RESULTS: M6P/IGF2R was found to be polymorphic in 73.3% (22/30) of the patients, and of these patients, 50.0% (11/22) had tumors showing LOH in M6P/IGF2R. Loss of heterozygosity in M6P/IGF2R was associated with significant reductions in the two year overall survival rate (24.9% vs 65.5%; P = 0.04) and the disease-free survival rate (17.8% vs 59.3%; P = 0.03). CONCLUSION: These results show M6P/IGF2R LOH predicts poor clinical outcomes in surgically resected primary HCC patients.	Hong Seok Jang Ki Mun Kang Byung Ock Choi Gyu Young Chai Soon Chan Hong Woo Song Ha Randy L Jirtle	2008	World Journal of Gastroenterology2008，14，9：	12
2	The releveance of transforming growth factor beta1 in pulmonary injury after radiation therapy显示文摘	Anscher MS Kong FM Jirtle RL	1998	Lung Cancer1998，19，2：	2
3	Plasma trans-forming growth factor-β1 reflects disease status in patientswith lung cancer after radiotherapy:a possible tumor marker显示文摘	Kong FM Washington MK Jirtle RL	1996	Lung Cancer1996，16，1：	1
4	Imprinting of PEG3, the human homologue of a mouse gene involved in nurturing behavior 显示文摘	Murphy S K Wylie A A Jirtle R L	2001	Genomics2001，71，：	1
5	The releveance of transforming growth factor betal in pulmonary injury aider radiation therapy显示文摘	Anscher MS Kong FM Jirtle RL	1998	Lung Cancer1998，19，2：	1
6	Environmental epig- enomics and disease susceptibility 显示文摘	JIRTLE R L SKINNER M K	2007	Nature Reviews Genetics2007，8，4：	1
7	Imprinting evolution and the price of silence显示文摘	Murphy SK Jirtle RL	2003	Bioessays2003，25，6：	1
8	A paternal environmental legacy: evidence for epigenetic inheritance through the male germ line 显示文摘	Soubry A Hoyo C Jirtle RL	2014	Bioessays2014，36，4：	1
9	Environmental epigenomics and disease susceptibility显示文摘	JIRTLE R L SKINNER M K	2007	Nat Rev Genet2007，8，：	1
10	Transforminggrowth factorb-1 expressionin irradiated Iiver显示文摘	Allsoher MS Crocker IR Jirtle RL	1990	Radiat Res1990，122，1：	1
11	Developmental relaxation of insulin-like growth factor 2 imprinting in kidney is determined by weanling diet显示文摘	Waterland RA Jirtle RL	2003	Pediatr Res2003，，：	1
12	Transposable elements: targets for early nutritional effects on epigenetic gene regulation 显示文摘	Waterland R A Jirtle R L	2003	Mol Cell Biol2003，23，：	1
13	Environmental epigenomics in human health and disease显示文摘	DOLINOY D C JIRTLE R L	2008	Environ Mol Mutagen2008，49，：	1
14	Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development显示文摘	Dolinoy DC Huang D Jirtle RL	2007	Proc Natl Acad Sci USA2007，104，13：	1
15	Transposable elements: targets for early nutritional effects on epigenetic gene regulation 显示文摘	Waterland R A Jirtle R L	2003	Mol Cell Biol2003，23，15：	1
16	Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases显示文摘	Waterland RA Jirtle RL	2004	Nutrition2004，20，1：	1
17	Abnormal postnatal maintenance of elevated DLK1 transcript levels in callipyge sheep显示文摘	Susan K. Murphy Brad A. Freking Timothy P.L. Smith Kreg Leymaster Catherine M. Nolan Andrew A. Wylie Heather K. Evans Randy L. Jirtle	2005	Mammalian Genome2005，，3：	1
18	Maternal nutrient supplementation counteracts bisphenol A--induced DNA laypomethylation in early development 显示文摘	Dolinoy DC Huang D Jirtle RL	2007	Proc Natl Acad Sci USA2007，104，32：	1
19	The relevance of transforming growth factor beta 1 in pulmonary injury after radiation therapy显示文摘	ANSCHER M S KONG F M JIRTLE R L		0，，02：	1
20	Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases显示文摘	Waterland RA Jirtle RL	2004	Nutrition2004，20，1：	1

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