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| 1 | FKF1 F-box protein promotes flowering in part by negatively regulating DELLA protein stability under long-day photoperiod in Arabidopsis^FA显示文摘FLAVIN-BINDING KELCH REPEAT F-BOX 1(FKF1)encodes an F-box protein that regulates photoperiod flowering in Arabidopsis under long-day conditions(LDs).Gibberellin(GA)is also important for regulating flowering under LDs.However,how FKF1 and the GA pathway work in concert in regulating flowering is not fully understood.Here,we showed that the mutation of FKF1 could cause accumulation of DELLA proteins,which are crucial repressors in GA signaling pathway,thereby reducing plant sensitivity to GA in flowering.Both in vitro and in vivo biochemical analyses demonstrated that FKF1 directly interacted with DELLA proteins.Furthermore,we showed that FKF1 promoted ubiquitination and degradation of DELLA proteins.Analysis of genetic data revealed that FKF1 acted partially through DELLAs to regulate flowering under LDs.In addition,DELLAs exerted a negative feedback on FKF1 expression.Collectively,these findings demonstrate that FKF1 promotes flowering partially by negatively regulating DELLA protein stability under LDs,and suggesting a potential mechanism linking the FKF1 to the GA signaling DELLA proteins. | Jindong Yan Xinmei Li Bingjie Zeng Ming Zhong Jiaxin Yang Piao Yang Xin Li Chongsheng He Jianzhong Lin Xuanming Liu Xiaoying Zhao | 2020 | Journal of Integrative Plant Biology2020，62，11： | 8 |
| 2 | Influence of CeO2 loading on structure and catalytic activity for NH3-SCR over TiO2-supported CeO2显示文摘A series of supported CeO2/TiO2 catalysts were prepared to explore the influence of CeO2 loading on these catalysts for the selective catalytic reduction of NO3 by NH3(NH3-SCR).The catalysts were investigated in detail by means of XRD,Raman,H2-TPR,NH3-TPD,XPS,in situ DRIFTS,and NH3-SCR reaction.The activity of the catalyst is closely related to the content of CeO2.When the loading of CeO2 is near the dispersion capacity(1.16 mmol Ce4+/100 m^2 TiO2),the catalytic activity is better.This may be because that the dispersed CeO2 is the active species and the catalyst has appropriate redox property,along with the larger amounts of surface Ce content and surface adsorbed oxygen species.Finally,a possible reaction mechanism via the Langmuir-Hinshelwood(L-H)mechanism is tentatively proposed to further understand the NH3-SCR reaction. | Hongliang Zhang Long Ding Hongming Long Jiaxin Li Wei Tan Jiawei Ji Jingfang Sun Changjin Tang Lin Dong | 2020 | Journal of Rare Earths2020，38，8： | 5 |
| 3 | Nano-crystalline FeOOH mixed with SWNT matrix as a superior anode material for lithium batteries显示文摘Nano-crystalline FeOOH particles(5~10 nm) have been uniformly mixed with electric matrix of single-walled carbon nanotubes(SWNTs)for forming FeOOH/SWNT composite via a facile ultrasonication method. Directly using the FeOOH/SWNT composite(containing 15 wt%SWNTs) as anode material for lithium battery enhances kinetics of the Li+insertion/extraction processes, thereby effectively improving reversible capacity and cycle performance, which delivers a high reversible capacity of 758 mAh g-1under a current density of 400 mA g-1even after 180 cycles, being comparable with previous reports in terms of electrochemical performance for FeOOH anode. The good electrochemical performance should be ascribed to the small particle size and nano-crystalline of FeOOH, as well as the good electronic conductivity of SWNT matrix. | Mingzhong Zou Weiwei Wen Jiaxin Li Yingbin Lin Heng Lai Zhigao Huang | 2014 | Journal of Energy Chemistry2014，23，4： | 3 |
| 4 | Synthetic lethal short hairpin RNA screening reveals that ring finger protein 183 confers resistance to trametinib in colorectal cancer cells显示文摘Background: The mitogen-activated extracellular signal-regulated kinase 1/2(MEK1/2) inhibitor trametinib has shown promising therapeutic effects on melanoma, but its efficacy on colorectal cancer(CRC) is limited. Synthetic lethality arises with a combination of two or more separate gene mutations that causes cell death, whereas individual mutations keep cells alive. This study aimed to identify the genes responsible for resistance to trametinib in CRC cells,using a synthetic lethal short hairpin RNA(shRNA) screening approach.Methods: We infected HT29 cells with a pooled lentiviral shRNA library and applied next-generation sequencing to identify shRNAs with reduced abundance after 8-day treatment of 20 nmol/L trametinib. HCT116 and HT29 cells were used in validation studies. Stable ring finger protein 183(RNF183)-overexpressing cell lines were generated by pcDNA4-myc/his-RNF183 transfection. Stable RNF 183-knockdown cell lines were generated by infection of lentiviruses that express RNF183 shRNA, and small interference RNA(siRNA) was used to knock down RNF183 transiently.Quantitative real-time PCR was used to determine the mRNA expression. Western blotting, immunohistochemical analysis, and enzyme-linked immunosorbent assay(ELISA) were used to evaluate the protein abundance. MTT assay,colony formation assay, and subcutaneous xenograft tumor growth model were used to evaluate cell proliferation.Results: In the primary screening, we found that the abundance of RNF183 shRNA was markedly reduced after treatment with trametinib. Trametinib induced the expression of RNF183, which conferred resistance to drug-induced cell growth repression and apoptotic and non-apoptotic cell deaths. Moreover, interleukin-8(IL-8) was a downstream gene of RNF183 and was required for the function of RNF183 in facilitating cell growth. Additionally, elevated RNF183 expression partly reduced the inhibitory effect of trametinib on IL-8 expression. Finally, xenograft tumor model showed the synergism of RNF183 knockdown and trametinib in repressing the growth of CRC cells in vivo.Conclusion: The RNF183-IL-8 axis is responsible for the resistance of CRC cells to the MEK1/2 inhibitor trametinib and may serve as a candidate target for combined therapy for CRC. | Rong Geng Xin Tan Zhixiang Zuo Jiangxue Wu Zhizhong Pan Wei Shi Ranyi Liu Chen Yao Gaoyuan Wang Jiaxin Lin Lin Qiu Wenlin Huang Shuai Chen | 2017 | Chinese Journal of Cancer2017，36，12： | 2 |
| 5 | Boosting the cell performance of the SiO_(x)@C anode material via rational design of a Si-valence gradient显示文摘Relieving the stress or strain associated with volume change is highly desirable for high-performance SiOx anodes in terms of stable solid electrolyte interphase(SEI)-film growth.Herein,a Si-valence gradient is optimized in SiOx composites to circumvent the large volume strain accompanied by lithium insertion/extraction.SiO_(x)@C annealed at 850℃ has a gentle Si-valence gradient along the radial direction and excellent electrochemical performances,delivering a high capacity of 506.9 mAh g^(−1) at 1.0 A g^(−1) with a high Coulombic efficiency of~99.8%over 400 cycles.Combined with the theoretical prediction,the obtained results indicate that the gentle Si-valence gradient in SiO_(x)@C is useful for suppressing plastic deformation and maintaining the inner connection integrity within the SiO_(x)@C particle.Moreover,a gentle Si-valence gradient is expected to form a stress gradient and affect the distribution of dangling bonds,resulting in local stress relief during the lithiation/delithiation process and enhanced Li-ion kinetic diffusion.Furthermore,the lowest interfacial stress variation ensures a stable SEI film at the interface and consequently increases cycling stability.Therefore,rational design of a Si-valence gradient in SiOx can provide further insights into achieving high-performance SiOx anodes with large-scale production. | Jianming Tao Zerui Yan Jiangshao Yang Jiaxin Li Yingbin Lin Zhigao Huang | 2022 | Carbon Energy2022，4，2： | 2 |
| 6 | Effect of NaOH Treatment on Catalytic Performance of ZSM -5 in Cyclohexene Hydration显示文摘ZSM-5 zeolite prepared by a hydrothermal method with the addition of seeds was treated with different concentrations of NaOH.The obtained samples were characterized by XRD,N_2 adsorption,NH_3-TPD,FT-IR,SEM,and studied in the catalytic performance of the hydration of cyclohexene to cyclohexanol.The characterization results showed that with the increase of NaOH concentration,the crystallinity of the treated samples decreased monotonously,and the acid sites of ZSM-5 zeolites first increased and then decreased,while more mesopores formed inside the ZSM-5zeolites.The experimental results of catalytic performance showed that cyclohexene conversion can be improved through introducing the mesopores and enhancing the acidity of ZSM-5 with the NaOH treatment at a low concentration.The highest cyclohexene conversion of 12.8%was obtained when the concentrations of NaOH solution were in the range of 0.2-0.6 mol/L.The selectivity of cyclohexanol on all samples was higher than 99.6%. | Yaquan Wang Shougui Wang Fanjun Meng Shuhai Wang Jiaxin Ye Yongjie Lin | 2017 | Transactions of Tianjin University2017，23，1： | 1 |
| 7 | Wavelength-Dependent Solar N_(2) Fixation into Ammonia and Nitrate in Pure Water显示文摘Solar-driven N_(2) fixation using a photocatalyst in water presents a promising alternative to the traditional Haber-Bosch process in terms of both energy efficiency and environmental concern.At present,the product of solar N_(2) fixation is either NH_(4)^(+)or NO_(3)^(-).Few reports described the simultaneous formation of ammonia(NH_(4)^(+))and nitrate(NO_(3)^(-))by a photocatalytic reaction and the related mechanism.In this work,we report a strategy to photocatalytically fix nitrogen through simultaneous reduction and oxidation to produce NH_(4)^(+)and NO_(3)^(-)byW18O49 nanowires in pure water.The underlying mechanism of wavelength-dependent N_(2) fixation in the presence of surface defects is proposed,with an emphasis on oxygen vacancies that not only facilitate the activation and dissociation of N_(2) but also improve light absorption and the separation of the photoexcited carriers.Both NH_(4)^(+)and NO_(3)^(-)can be produced in pure water under a simulated solar light and even till the wavelength reaching 730 nm.The maximum quantum efficiency reaches 9%at 365 nm.Theoretical calculation reveals that disproportionation reaction of the N_(2) molecule is more energetically favorable than either reduction or oxidation alone.It is worth noting that the molar fraction of NH_(4)^(+)in the total product(NH_(4)^(+)plus NO_(3)^(-))shows an inverted volcano shape from 365nm to 730 nm.The increased fraction of NO_(3)^(-)from 365 nm to around 427 nm results from the competition between the oxygen evolution reaction(OER)at W sites without oxygen vacancies and the N_(2) oxidation reaction(NOR)at oxygen vacancy sites,which is driven by the intrinsically delocalized photoexcited holes.From 427nm to 730 nm,NOR is energetically restricted due to its higher equilibrium potential than that of OER,accompanied by the localized photoexcited holes on oxygen vacancies.Full disproportionation of N_(2) is achieved within a range of wavelength from~427nm to~515 nm.This work presents a rational strategy to efficiently utilize the photoexcited carriers and optimize the photocatalyst for practical nitrogen fixation. | Wenju Ren Zongwei Mei Shisheng Zheng Shunning Li Yuanmin Zhu Jiaxin Zheng Yuan Lin Haibiao Chen Meng Gu Feng Pan | 2020 | Research2020，，1： | 1 |
| 8 | Boosting K-ion kinetics by interfacial polarization induced by amorphous MoO_(3-x)for MoSe_(2)/MoO_(3-x)@rGO composites显示文摘Promoting interfacial reaction kinetics is highly desirable for achieving high-performances of anode material in alkali-ion batteries.Herein,flower-like MoSe_(2)/MoO_(3-x)@r GO composites are fabricated by a facile solvothermal method involving a thermal-treatment at 800°C.When evaluated as an anode material for potassium ion batteries,MoSe_(2)/MoO_(3-x)@r GO delivers 248.2 m A h g^(-1)after 50 cycles at 0.2 A g^(-1) with a capacity retention of 84.6%and 182.9 m A h g^(-1)after 150 cycles at 1.0 A g^(-1) with a capacity retention of almost 61.2%,superior to those of bare MoSe_(2)or MoSe_(2)@r GO composites.Analysis from electrochemical measurements,the amorphous MoO_(3-x)containing oxygen vacancies could not only effectively buffer the self-aggregation of MoSe_(2)nanosheets but also provides lots of accessible active sites for potassium ion storage.Additionally,the open channels in the amorphous MoO_(3-x) phase lead to easier ion hopping and smaller diffusion barriers.Furthermore,the built-in electric field at the interface would be beneficial for electron transfer and K-ion migration across the hetero-junction interface.Moreover,larger dielectric polarization induced by the high relative permittivity of amorphous MoO_(3-x) would reduce charge transfer resistance and enhance K-ion migration across electric double-layer.Our work provides new insight into the enhanced performance of anode material coated by an amorphous layer with large relative permittivity. | Jiangshao Yang Liwen Liu Daoyi Wang Jianming Tao Yanming Yang Jiaxin Li Yingbin Lin Zhigao Huang | 2022 | Journal of Materials Science & Technology2022，，20： | 1 |
| 9 | Characterization of SARS-CoV-2-specific humoral immunity and its potential applications and therapeutic prospects显示文摘Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is an ongoing pandemic that poses a great threat to human health worldwide.As the humoral immune response plays essential roles in disease occurrence and development,understanding the dynamics and characteristics of virus-specific humoral immunity in SARS-CoV-2-infected patients is of great importance for controlling this disease.In this review,we summarize the characteristics of the humoral immune response after SARS-CoV-2 infection and further emphasize the potential applications and therapeutic prospects of SARSCoV-2-specific humoral immunity and the critical role of this immunity in vaccine development.Notably,serological antibody testing based on the humoral immune response can guide public health measures and control strategies;however,it is not recommended for population surveys in areas with very low prevalence.Existing evidence suggests that asymptomatic individuals have a weaker immune response to SARS-CoV-2 infection,whereas SARS-CoV-2-infected children have a more effective humoral immune response than adults.The correlations between antibody(especially neutralizing antibody)titers and protection against SARS-CoV-2 reinfection should be further examined.In addition,the emergence of cross-reactions among different coronavirus antigens in the development of screening technology and the risk of antibody-dependent enhancement related to SARS-CoV-2 vaccination should be given further attention. | Jiaxin Zheng Yingying Deng Zhenyu Zhao Binli Mao Mengji Lu Yong Lin Ailong Huang | 2022 | Cellular & Molecular Immunology2022，19，2： | 1 |
| 10 | Unsupervised Binary Protocol Clustering Based on Maximum Sequential Patterns显示文摘With the rapid development of the Internet,a large number of private protocols emerge on the network.However,some of them are constructed by attackers to avoid being analyzed,posing a threat to computer network security.The blockchain uses the P2P protocol to implement various functions across the network.Furthermore,the P2P protocol format of blockchain may differ from the standard format specification,which leads to sniffing tools such as Wireshark and Fiddler not being able to recognize them.Therefore,the ability to distinguish different types of unknown network protocols is vital for network security.In this paper,we propose an unsupervised clustering algorithm based on maximum frequent sequences for binary protocols,which can distinguish various unknown protocols to provide support for analyzing unknown protocol formats.We mine the maximum frequent sequences of protocolmessage sets in bytes.Andwe calculate the fuzzymembership of the protocolmessage to each maximum frequent sequence,which is based on fuzzy set theory.Then we construct the fuzzy membership vector for each protocol message.Finally,we adopt K-means++to split different types of protocol messages into several clusters and evaluate the performance by calculating homogeneity,integrity,and Fowlkes and Mallows Index(FMI).Besides,the clustering algorithms based onNeedleman–Wunsch and the fixed-length prefix are compared with the algorithm presented in this paper.Compared with these traditional clustering methods,we demonstrate a certain improvement in the clustering performance of our work. | Jiaxin Shi Lin Ye Zhongwei Li Dongyang Zhan | 2022 | Computer Modeling in Engineering & Sciences2022，，1： | 1 |
| 11 | Calculating electron-phonon coupling matrix: Theory introduction,code development and preliminary application显示文摘Electron-phonon coupling(EPC) in bulk materials is an important effect in multifarious physical and chemical phenomena. It is the key to explaining the mechanisms for superconductivity, electronic transport, etc. The EPC matrix describes the coupling of the electronic eigenstates of the studied system under the perturbation of phonons. Although the EPC matrix is closely relevant to many fundamental physicochemical properties, it remains a challenge to calculate the EPC matrix precisely due to the high computational cost. In recent years, Giustino et al. developed the EPW method on open-source ab-initio software Quantum Espresso, which uses Wannier functions(WFs) to calculate EPC matrix. However, due to the limitation of their implementation,it is not possible yet to calculate the EPC matrix under some important computational conditions, e.g., for DFT+U and HSE calculation. Given the importance of these computational conditions(e.g., for transition metal oxides), we have developed our own implementation of EPC matrix calculation based on the domestic ab-initio software PWmat. Our code allows the DFT+U and HSE correction, so we can get a more accurate EPC matrix in the related problems. In this article, we will first review the formulae and elucidate how to calculate the EPC matrix by constructing WFs. Then we will introduce our code along with its workflow on PWmat and present our test results of two classical semiconductor systems Al As and Si, showing consistency with EPW. Next, the EPC matrix of Li Co O_(2), a classical cathode material for lithium-ion batteries, is calculated using different exchange correlation(XC) functionals including LDA, PBE, DFT+U and HSE. A comparison is provided for the related EPC matrix. It shows there could be a significant difference for the EPC matrix elements due to the use of different XC functionals.Our implementation thus opens the way for fast calculation of EPC for the important class of materials, like the transition metal oxides. | YE YaoKun WENG MouYi ZHANG WenTao LIN WeiCheng CHEN TaoWen PAN Feng ZHENG JiaXin WANG Lin-Wang | 2023 | Science China(Technological Sciences)2023，66，1： | 1 |
| 12 | Generation of gene-target dogs using CRISPR/Cas9 system显示文摘Dear Editor,Dogs(Canis familiaris)serve as human companions and are raised to herd livestock,aid hunters,guard homes,perform police and rescue work,and guide the blind.Dogs exhibit close similarities to humans in terms of metabolic,physiological,and anatomical characteristics,and thus are ideal genetic and clinical models to study human diseases(Tsai et al.,2007).Gene target technology is a powerful tool to create new strains of animals with favorable traits.However,thus far,gene-target dogs have not been developed due to their unique species-specific reproductive characteristics,which limits the applications of dogs especially in the field of biomedical research.Recently,clustered regularly interspaced short palindromic repeats(CRISPRs)/CRISPR-associated(Cas)9 system was applied to edit specific genes with a high efficiency(Cong et al.,2013;Mali et al.,2013).Here we attempt to explore the feasibility of producing gene knockout(KO)dogs by using this technology.Beagle dog,the most widely used breed in biomedical research,was used as our animal model.Myostatin(MSTN)was chosen as the first gene of interest. | Qingjian Zou Xiaomin Wang Yunzhong Liu Zhen Ouyang Haibin Long Shu Wei Jige Xin Bentian Zhao Sisi Lai Jun Shen Qingchun Ni Huaqiang Yang Huilin Zhong Li Li Minhua Hu Quanjun Zhang Zhidong Zhou Jiaxin He Quanmei Yan Nana Fan Yu Zhao Zhaoming Liu Lin Guo Jiao Huang Guanguan Zhang Jun Ying Liangxue Lai Xiang Gao | 2015 | Journal of Molecular Cell Biology2015，7，6： | 1 |
| 13 | Coaxial MWNTs@MnO 2 confined in conducting PPy for kinetically efficient and long-term lithium ion storage显示文摘 | Jiaxin Li Mingzhong Zou Yi Zhao Yingbin Lin Heng Lai Lunhui Guan Zhigao Huang | 2013 | Electrochimica Acta2013，，： | 1 |
| 14 | 肝肠循环因子FGF15/19调节胆汁酸代谢从而控制肝脏尺寸大小与肝癌发生显示文摘文章简介肝脏是人体的一个重要代谢器官,它的大小相对于整个个体大小始终维持在一个合适的比例。肝脏如何感知生长起始和停止是肝脏发育、再生以及癌症生物学中一个有待解决的基本科学问题。近年来研究发现,Hippo信号通路在从果蝇到哺乳动物个体的器官发育及大小调控中都起着至关重要的作用。然而具体何种外部因子在调控Hippo信号通路来维持肝脏大小稳态及抑制癌症发生,一直是领域内未解决的问题。 | 姬素渊 刘清许 张世浩 陈青花 王聪 Weiji Zhang Chen Xiao Yuxi Li Cheng Nian Jiaxin Li Junhong Li Jing Geng Lixin Hong Changchuan Xie Ying He Xing Chen Xun Li Zhen-Yu Yin Han You Kwang-Huei Lin Qiao Wu Chundong Yu Randy L.Johnson Li Wang Lanfen Chen Fen Wang 周大旺 | 2020 | 科学新闻2020，，2： | 1 |
| 15 | Brain-wide N2cG compensation permits glycoprotein-deleted rabies virus to trace neural circuits across multiple synapses显示文摘Rabies-viruses-based retrograde tracers can spread across multiple synapses in a retrograde direction in the nervous system of rodents and primates,making them powerful tools for determining the structure and function of the complicated neural circuits of the brain.However,they have some limitations,such as posing high risks to human health and the inability to retrograde trans-synaptic label inputs from genetically-de¯ned starter neurons.Here,we established a new retrograde trans-multi-synaptic tracing method through brain-wide rabies virus glycoprotein(RVG)compensation,followed by glycoprotein-deleted rabies virus(RV-△G)infection in specific brain regions.Furthermore,in combination with the avian tumor virus receptor A(TVA)controlled by a cell-type-specific promoter,we found that EnvA-pseudotyped RV-△G can mediate e±cient retrograde trans-multi-synaptic transduction from cell-type-specific starter neurons.This study provides new alternative methods for neuroscience researchers to analyze the input neural networks of rodents and nonhuman primates. | Nengsong Luo Zengpeng Han Jiaxin Kou Yuxiang Cai Xin Yang Jie Wang Kunzhang Lin Fuqiang Xu | 2023 | Journal of Innovative Optical Health Sciences2023，16，6： | 1 |
| 16 | Cross-sectional rainfall observation on the central-western Tibetan Plateau in the warm season:System design and preliminary results显示文摘The central and western Tibetan Plateau(CWTP)is characterized by harsh environment and strong interactions among the spheres of earth as well as significant changes in climate and water cycles over the past four decades.The lack of precipitation observations is a bottleneck for the study of land surface processes in this region.Over the past six years,we have designed and established two observation transects across the south-north and the west-east in this region to obtain hourly rainfall data during the warm season(May-September).The south-north transect extends from Yadong Valley on the southern slope of the Himalayas to Shuanghu County in the hinterland of the plateau,with a total of 31stations;the west-east transect extends from Shiquanhe in the west to Naqu in the central TP,with a total of 22 stations.The observation dataset has been applied to clarify the spatiotemporal characteristics of precipitation in the CWTP,to evaluate the quality of typical gridded precipitation products,to support the development of regional climate models,and to reveal the processes of summertime lake-air interactions.The observation dataset has been released in the National Tibetan Plateau Data Center. | Kun YANG Yingying CHEN Lazhu Changhui ZHAN Xiaoyan LING Xu ZHOU Yaozhi JIANG Xiangnan YAO Hui LU Xiaogang MA Lin OUYANG Weihao PAN Yanghang REN Changkun SHAO Jiaxin TIAN Yan WANG Hua YANG Siyu YUE Ke ZHANG Dingchi ZHAO Long ZHAO Jianhong ZHOU Mijun ZOU | 2023 | Science China Earth Sciences2023，66，5： | 0 |
| 17 | An Experimental Study on the Interaction between Hydrate Formation and Wax Precipitation in Waxy Oil-in-Water Emulsions显示文摘The coupled formation of wax crystals and hydrates is a critical issue for the safety of deep-sea oil and gas exploration and subsea transport pipeline flow.Therefore,this paper conducts an experimental study on the characteristics of methane hydrate formation in a water-in-oil(W/O)system with different wax crystal contents and explores the influence of different initial experimental pressures on the induction period and maximum rate of hydrate formation.The wavelet function was introduced to process the reaction rate and calculate the maximum speed of hydrate formation.Notably,the higher the pressure,the smaller the maximum rate of hydrate formation.We observed that wax crystal precipitation increases the viscosity of the emulsion,which limits the diffusion of gas in the liquid phase during hydrate nucleation and thus delays the hydrate nucleation.The methane gas precipitation also affects the remaining fraction’s wax content and therefore affects the wax precipitation.Secondary hydrate formation was observed several times during the experiment,increasing the risk of pipeline blockage.Overall,this work provides insights into the effect of wax crystal precipitation on hydrate behaviour that could facilitate flow assurance applications in subsea multiphase pipelines and inform the safe transportation of oil and gas pipelines. | Xincan Song Lin Wang Cheng Yu Jiaxin Chen Linjie Ma | 2023 | Energy Engineering2023，120，8： | 0 |
| 18 | Characterization of Specific Humoral Immunity in Asymptomatic SARS-CoV-2 Infection显示文摘The outbreak of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in December 2019 caused a huge blow to both global public health and global economy.At the early stage of the coronavirus disease 2019(COVID-19)epidemic,asymptomatic individuals with SARS-CoV-2 infection were ignored,without appropriate identification and isolation.However,asymptomatic individuals proved to comprise a high proportion of all SARS-CoV-2-infected individuals,which greatly contributed to the rapid and wide spread of this disease.In this review,we summarize the latest advances in epidemiological characteristics,diagnostic assessment methods,factors related to the establishment of SARS-CoV-2 asymptomatic infection,as well as humoral immune features after SARS-CoV-2 infection or vaccination in asymptomatic individuals,which would contribute to effective control of ongoing COVID-19 epidemic. | Yingying Deng Jiaxin Zheng Yong Lin Ailong Huang | 2021 | Infectious Diseases & Immunity2021，1，3： | 0 |
| 19 | VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway显示文摘Although VEGF-B was discovered as a VEGF-A homolog a long time ago,the angiogenic effect of VEGF-B remains poorly understood with limited and diverse findings from different groups.Notwithstanding,drugs that inhibit VEGF-B together with other VEGF family members are being used to treat patients with various neovascular diseases.It is therefore critical to have a better understanding of the angiogenic effect of VEGF-B and the underlying mechanisms.Using comprehensive in vitro and in vivo methods and models,we reveal here for the first time an unexpected and surprising function of VEGF-B as an endogenous inhibitor of angiogenesis by inhibiting the FGF2/FGFR1 pathway when the latter is abundantly expressed.Mechanistically,we unveil that VEGF-B binds to FGFR1,induces FGFR1/VEGFR1 complex formation,and suppresses FGF2-induced Erk activation,and inhibits FGF2-driven angiogenesis and tumor growth.Our work uncovers a previously unrecognized novel function of VEGF-B in tethering the FGF2/FGFR1 pathway.Given the anti-angiogenic nature of VEGF-B under conditions of high FGF2/FGFR1 levels,caution is warranted when modulating VEGF-B activity to treat neovascular diseases. | Chunsik Lee Rongyuan Chen Guangli Sun Xialin Liu Xianchai Lin Chang He Liying Xing Lixian Liu Lasse DJensen Anil Kumar Harald FLanger Xiangrong Ren Jianing Zhang Lijuan Huang Xiangke Yin JongKyong Kim Juanhua Zhu Guanqun Huang Jiani Li Weiwei Lu Wei Chen Juanxi Liu Jiaxin Hu Qihang Sun Weisi Lu Lekun Fang Shasha Wang Haiqing Kuang Yihan Zhang Geng Tian Jia Mi Bi-Ang Kang Masashi Narazaki Aaron Prodeus Luc Schoonjans David MOrnitz Jean Gariepy Guy Eelen Mieke Dewerchin Yunlong Yang Jing-Song Ou Antonio Mora Jin Yao Chen Zhao Yizhi Liu Peter Carmeliet Yihai Cao Xuri Li | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 0 |
| 20 | Scalable synthesized high-performance TiO_(2)-Si-C hybrid anode for lithium batteries显示文摘At present,developing a simple strategy to effectively solve the shackles of volume expansion,poor conductivity and interface compatibility faced by Si-C anode in lithium batteries(LIBs)is the key to its commercialization.Here,low-cost nano-Si powders were prepared from Si-waste of solar-cells by sanding treatment,which can effectively reduce the commercialization cost for Si-C anode.Furthermore,micro-nano structured Gr@Si/C/TiO_(2) anode materials with graphite(Gr)as the inner core,TiO_(2)-doped and carbon-coated Si as the outer coating-layer,were synthesized at kilogram-scale per milling batch.Comprehensive characterization results indicate that TiO_(2)-doped carbon layer can improve the interface compatibility with the electrolyte,further promote the reduction of electrode polarization,and finally enhance the battery performance for the Gr@Si/C/TiO_(2) anodes.Accordingly,Gr@Si/C/TiO_(2) composites can output excellent LIB performance,especially with high initial coulombic efficiency(ICE)of 82.51%and large average reversible capacity of~810 mA h g^(-1) at 0.8 A g^(-1) after 1000 cycles.Moreover,Gr@Si/C/TiO_(2)‖NCM811 pouch full cells deliver impressive performance especially with high energy density of~489.3 W h kg^(-1) based on the total weight of active materials,suggesting its promising application in the high performance LIBs. | Liao Shen Chengjie Xu Jingguo Gao Jianming Tao Qiaobao Zhang Yue Chen Yingbin Lin Zhigao Huang Jiaxin Li | 2023 | Journal of Energy Chemistry2023，，2： | 0 |
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