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| 1 | Management of granulomatous lobular mastitis: an international multidisciplinary consensus(2021 edition)显示文摘Granulomatous lobular mastitis(GLM) is a rare and chronic benign inflammatory disease of the breast. Difficulties exist in the management of GLM for many front-line surgeons and medical specialists who care for patients with inflammatory disorders of the breast. This consensus is summarized to establish evidence-based recommendations for the management of GLM. Literature was reviewed using PubMed from January 1, 1971 to July 31, 2020. Sixty-six international experienced multidisciplinary experts from 11 countries or regions were invited to review the evidence.Levels of evidence were determined using the American College of Physicians grading system, and recommendations were discussed until consensus. Experts discussed and concluded 30 recommendations on historical definitions,etiology and predisposing factors, diagnosis criteria, treatment, clinical stages, relapse and recurrence of GLM. GLM was recommended as a widely accepted definition. In addition, this consensus introduced a new clinical stages and management algorithm for GLM to provide individual treatment strategies. In conclusion, diagnosis of GLM depends on a combination of history, clinical manifestations, imaging examinations, laboratory examinations and pathology.The approach to treatment of GLM should be applied according to the different clinical stage of GLM. This evidencebased consensus would be valuable to assist front-line surgeons and medical specialists in the optimal management of GLM. | Qian-Qian Yuan Shu-Yuan Xiao Omar Farouk Yu-Tang Du Fereshte Sheybani Qing Ting Tan Sami Akbulut Kenan Cetin Afsaneh Alikhassi Rami Jalal Yaghan Irmak Durur-Subasi Fatih Altintoprak Tae Ik Eom Fatih Alper Mustafa Hasbahceci David Martínez-Ramos Pelin Seher Oztekin Ava Kwong Cedric W.Pluguez-Turul Kirstyn EBrownson Shirish Chandanwale Mehran Habib Liu-Yi Lan Rui Zhou Xian-Tao Zeng Jiao Bai Jun-Wen Bai Qiong-Rong Chen Xing Chen Xiao-Ming Zha Wen-Jie Dai Zhi-Jun Dai Qin-Yu Feng Qing-Jun Gao Run-Fang Gao Bao-San Han Jin-Xuan Hou Wei Hou Hai-Ying Liao Hong Luo Zheng-Ren Liu Jing-Hua Lu Bin Luo Xiao-Peng Ma Jun Qian Jian-Yong Qin Wei Wei Gang Wei Li-Ying Xu Hui-Chao Xue Hua-Wei Yang Wei-Ge Yang Chao-Jie Zhang Fan Zhang Guan-Xin Zhang Shao-Kun Zhang Shu-Qun Zhang Ye-Qiang Zhang Yue-Peng Zhang Sheng-Chu Zhang Dai-Wei Zhao Xiang-Min Zheng Le-Wei Zheng Gao-Ran Xu Wen-Bo Zhou Gao-Song Wu | 2022 | Military Medical Research2022，9，4： | 13 |
| 2 | Rapid generation of genetic diversity by multiplex CRISPR/Cas9 genome editing in rice显示文摘The clustered regularly interspaced short palindromic repeats(CRISPR)-associated endonuclease 9(CRISPR/Cas9) system has emerged as a promising technology for specific genome editing in many species. Here we constructed one vector targeting eight agronomic genes in rice using the CRISPR/Cas9 multiplex genome editing system. By subsequent genetic transformation and DNA sequencing, we found that the eight target genes have high mutation efficiencies in the T_0 generation. Both heterozygous and homozygous mutations of all editing genes were obtained in T_0 plants. In addition, homozygous sextuple, septuple, and octuple mutants were identified. As the abundant genotypes in T_0 transgenic plants, various phenotypes related to the editing genes were observed. The findings demonstrate the potential of the CRISPR/Cas9 system for rapid introduction of genetic diversity during crop breeding. | Lan Shen Yufeng Hua Yaping Fu Jian Li Qing Liu Xiaozhen Jiao Gaowei Xin Junjie Wang Xingchun Wang Changjie Yan Kejian Wang | 2017 | Science China(Life Sciences)2017，60，5： | 11 |
| 3 | ABNORMAL FLOWER AND GRAIN 1 encodes OsMADS6 and determines palea identity and affects rice grain yield and quality显示文摘The palea and lemma are floral organ structures unique to grasses;these structures form the hull and directly affect grain size and quality. However, the molecular mechanisms controlling the development of the hull are not well understood. In this study, we characterized the rice(Oryza sativa) abnormal flower and grain1(afg1) mutant, a new allele of OsMADS6. Similar to previously characterized osmads6 alleles, in the afg1 floret, the palea lost its marginal region and acquired the lemma identity. However, in contrast to other osmads6 alleles, the afg1 mutant showed altered grain size and grain quality, with decreased total starch and amylose contents, and increased protein and soluble sugar contents. The analysis of transcriptional activity suggested that AFG1 is a transcriptional activator and may affect grain size by regulating the expression levels of several genes related to cell expansion and proliferation in the afg1 mutant. These results revealed that AFG1 plays an important role in determining palea identity and affecting grain yield and quality in rice. | Xiaoqi Yu Saisai Xia Qiankun Xu Yuanjiang Cui Ming Gong Dali Zeng Qiang Zhang Lan Shen Guiai Jiao Zhenyu Gao Jiang Hu Guangheng Zhang Li Zhu Longbiao Guo Deyong Ren Qian Qian | 2020 | Science China(Life Sciences)2020，63，2： | 10 |
| 4 | Microbial dark matter coming to light:challenges and opportunities显示文摘Microbes are the most abundant and diverse cellular life forms on Earth and colonize a wide range of environmental niches.However,more than 99%of bacterial and archaeal species have not been obtained in pure culture[1]and we have only glimpsed the surface of this mysterious microbial world. | Jian-Yu Jiao Lan Liu Zheng-Shuang Hua Bao-Zhu Fang En-Min Zhou Nimaichand Salam Brian PHedlund Wen-Jun Li | 2021 | National Science Review2021，8，3： | 6 |
| 5 | King cobra peptide OH-CATH30 as a potential candidate drug through clinic drug-resistant isolates显示文摘Cationic antimicrobial peptides(AMPs) are considered as important candidate therapeutic agents, which exert potent microbicidal properties against bacteria, fungi and some viruses. Based on our previous findings king cobra cathelicidin(OH-CATH) is a 34-amino acid peptide that exerts strong antibacterial and weak hemolytic activity. The aim of this research is to evaluate the efficacy of both OH-CATH30 and its analog D-OH-CATH30 against clinical isolates comparing with routinely utilized antibiotics in vitro.In this study, 584 clinical isolates were tested(spanning 2013-2016) and the efficacy of the candidate peptides and antibiotics were determined by a broth microdilution method according to the CLSI guidelines. Among the 584 clinical isolates, 85% were susceptible to OH-CATH30 and its analogs. Both L-and D-OH-CATH30 showed higher efficacy against(toward) Gram-positive bacteria and stronger antibacterial activity against nearly all Gram-negative bacteria tested compare with antibiotics. The highest bactericidal activity was detected against Acinetobacter spp., including multi-drug-resistant Acinetobacter baumannii(MRAB)and methicillin-resistant Staphylococcus aureus(MRSA). The overall efficacy of OH-CATH30 and its analogs was higher than that of the 9 routinely used antibiotics. OH-CATH30 is a promising candidate drug for the treatment of a wide variety of bacterial infections which are resistant to many routinely used antimicrobial agents. | Feng Zhao Xin-Qiang Lan Yan Du Pei-Yi Chen Jiao Zhao Fang Zhao Wen-Hui Lee Yun Zhang | 2018 | Zoological Research2018，39，2： | 5 |
| 6 | VqMAPKKK38 is essential for stilbene accumulation in grapevine显示文摘Vitis species,including grapevine,produce a class of secondary metabolites called stilbenes that are important for plant disease resistance and can have positive effects on human health.Mitogen-activated protein kinase(MAPK)signaling cascades not only play key roles in plant defense responses but also contribute to stilbene biosynthesis in grapevine.MAPKKKs function at the upper level of the MAPK network and initiate signaling through this pathway.In this study,a Raf-like MAPKKK gene,VqMAPKKK38,was identified and functionally characterized from the Chinese wild grapevine V.quinquangularis accession‘Danfeng-2’.We observed that VqMAPKKK38 transcript levels were elevated by powdery mildew infection,high salinity conditions and chilling stresses,as well as in response to treatments by the hormones salicylic acid(SA),methyl jasmonate(MeJA),ethylene(Eth)and abscisic acid(ABA).In addition,based on both transient overexpression and gene suppression of VqMAPKKK38 in grapevine leaves,we found that VqMAPKKK38 positively regulates stilbene synthase transcription and stilbene accumulation probably by mediating the activation of the transcription factor MYB14.In addition,both hydrogen peroxide(H2O2)and calcium influx activated VqMAPKKK38 expression and stilbene biosynthesis,which suggests that VqMAPKKK38 may be involved in the calcium signaling and ROS signaling pathways. | Yuntong Jiao Dan Wang Lan Wang Changyue Jiang Yuejin Wang | 2017 | Horticulture Research2017，4，1： | 4 |
| 7 | Investigation on the Influence of Refrigerant Charge Amount on the Cooling Performance of Air Conditioning Heat Pump System for Electric Vehicles显示文摘The application of air conditioning heat pump(ACHP) in electric vehicles could lead to significant electrical power saving effect. As for an air conditioning heat pump system for electric vehicles, the influence of refrigerant charge amount should be investigated during the design phase. In this study, experimental method was employed to investigate the influence of the refrigerant charge amount on the performance of the ACHP system. The results showed that the refrigerant charge amount had different influence on the refrigerant properties at various locations within the system. The coefficient of performance and pressure-enthalpy diagram were calculated, and showed a close relationship with refrigerant charge amount under different compressor speeds. The degree of subcooling and the degree of superheating were recorded and the critical charge amount was determined by a typical practical test method. In addition, the critical refrigerant charge amount determined by the experimental method was also compared with two typical void fraction correlation models, and the model with consideration of two phase stream reaction of the refrigerant showed a good estimation accuracy on the critical charge amount. | LI Kang LAN Jiao ZHOU Guoliang TANG Qitian CHENG Qia FANG Yidong SU Lin | 2019 | Journal of Thermal Science2019，28，2： | 3 |
| 8 | Systematic study of H2 production from catalytic photoreforming of cellulose over Pt catalysts supported on TiO2显示文摘Hydrogen(H2)production from photocatalytic reforming of cellulose is a promising way for sustainable H2 to be generated.Herein,we report a systematic study of the photocatalytic reforming of cellulose over Pt/m-TiO2(i.e.mixed TiO2,80%of anatase and 20%of rutile)catalysts in water.The optimum operation condition was established by studying the effect of Pt loading,catalyst concentration,cellulose concentration and reaction temperature on the gas production rate of H2(r(H2))and CO2(r(CO2)),suggesting an optimum operation condition at 40°C with 1.0 g·L^-1of cellulose and 0.75 g·L^-1of 0.16-Pt/m-TiO2 catalyst(with 0.16 wt%Pt loadting)to achieve a relatively sound photocatalytic performance with rH2=9.95μmol·h^-1.It is also shown that although the photoreforming of cellulose was operated at a relatively mild condition(i.e.with an UV-A lamp irradiation at40°C in the aqueous system),a low loading of Pt at^0.16 wt%on m-TiO2 could promote the H2 production effectively.Additionally,by comparing the reaction order expressed from both r(H2)(a1)and r(CO2)(a2)with respect to cellulose and water,the possible mechanism of H2 production was proposed. | Lan Lan Yan Shao Yilai Jiao Rongxin Zhang Christopher Hardacre Xiaolei Fan | 2020 | Chinese Journal of Chemical Engineering2020，28，8： | 3 |
| 9 | Blood transcriptome analysis reveals gene expression features of breast-feeding rhesus macaque(Macaca mulatta)infants显示文摘DEAR EDITOR,During the breast-feeding period,infants undergo remarkable changes,including rapid physiological and developmental growth.However,little is known about gene expression features and sex-specific gene expression in breast-feeding infants.In this study,we sequenced 32 blood transcriptomes from 16 breast-feeding rhesus macaque(Macaca mulatta)infants and their lactating mothers.We identified 218 differentially expressed genes(DEGs)between infants and mothers,including 91 up-regulated and 127 down-regulated DEGs in the infant group. | Yue Lan Jiao Wang Qiao Yang Rui-Xiang Tang Min Zhou Guang-Lun Lei Jing Li Liang Zhang Bi-Song Yue Zhen-Xin Fan | 2020 | Zoological Research2020，41，4： | 2 |
| 10 | Expression and Characterization of ArgR, An Arginine Regulatory Protein in Corynebacterium crenatum显示文摘Objective Corynebacterium crenatum MT, a mutant from C. crenatum AS 1.542 with a lethal argR gene, exhibits high arginine production. To confirm the effect of ArgR on arginine biosynthesis in C. crenatum, an intact argR gene from wild-type AS 1.542 was introduced into C. crenatum MT, resulting in C. crenatum MT. sp, and the changes of transcriptional levels of the arginine biosynthetic genes and arginine production were compared between the mutant strain and the recombinant strain. Methods Quantitative real-time polymerase chain reaction was employed to analyze the changes of the related genes at the transcriptional level, electrophoretic mobility shift assays were used to determine ArgR binding with the argCJBDF, argGH, and carAB promoter regions, and arginine production was determined with an automated amino acid analyzer. Results Arginine production assays showed a 69.9% reduction in arginine from 9.01±0.22 mg/mL in C. crenatum MT to 2.71±0.13 mg/mL(P<0.05) in C. crenatum MT. sp. The argC, argB, argD, argF, argJ, argG, and carA genes were down-regulated significantly in C. crenatum MT. sp compared with those in its parental C. crenatum MT strain. The electrophoretic mobility shift assays showed that the promoter regions were directly bound to the ArgR protein. Conclusion The arginine biosynthetic genes in C. crenatum are clearly controlled by the negative regulator ArgR, and intact ArgR in C. crenatum MT results in a significant descrease in arginine production. | CHEN Xue Lan ZHANG Bin TANG Li JIAO Hai Tao XU Heng Yi XU Feng XU Hong WEI Hua XIONG Yong Hua | 2014 | Biomedical and Environmental Sciences2014，27，6： | 2 |
| 11 | Peptide-based pan-CoV fusion inhibitors maintain high potency against SARS-CoV-2 Omicron variant显示文摘Dear Editor,Most recently,a new SARS-CoV-2 variant of concern(VOC)Z Omicron(B.1.1.529),was first reported to the World Health Organization(WHO)from South Africa and then quickly spread to many countries,1,2 posing a serious threat to current vaccine prevention and antibody therapeutic strategies.Several studies have reported that the Omicron variant successfully escapes from neutralizing antibodies elicited by COVID-19 vaccines or from COVID-19 convalescent patients. | Shuai Xia Jasper Fuk-Woo Chan Lijue Wang Fanke Jiao Kenn Ka-Heng Chik Hin Chu Qiaoshuai Lan Wei Xu Qian Wang Chao Wang Kwok-Yu ng Yuen Lu Lu Shibo Jiang | 2022 | Cell Research2022，32，4： | 2 |
| 12 | LMP2-DC Vaccine Elicits Specific EBV-LMP2 Response to Effectively Improve Immunotherapy in Patients with Nasopharyngeal Cancer显示文摘Objective To evaluate the safety and effectiveness of a vaccine based on latent membrane protein 2(LMP2)modified dendritic cells(DCs)that boosts specific responses of cytotoxic T lymphocytes(CTLs)to LMP2 before and after intradermal injection in patients with nasopharyngeal carcinoma(NPC).Methods DCs were derived from peripheral blood monocytes of patients with NPC.We prepared LMP2-DCs infected by recombinant adenovirus vector expressing LMP2(rAd-LMP2).NPC patients were immunized with 2×105 LMP2-DCs by intradermal injection at week 0 and after the second and fourth weeks.Specific responses to LMP2 were detected by enzyme-linked immunospot(ELISPOT)assay at week 0 and at the fifth and eighth weeks.Local clinicians performed the follow-up and tracking of patients.Results We demonstrated that DCs derived from monocytes displayed typical DC morphologies;the expression of LMP2 in the LMP2-DCs vaccine was confirmed by immunocytochemical assay.Twenty-nine patients with NPC were enrolled in this clinical trial.The LMP2-DCs vaccine was well tolerated in all of the patients.Boosted responses to LMP2 peptide sub-pools were observed in 18 of the 29 patients with NPC.The follow-up data of 29 immunized patients from April,2010 to April 2015 indicated a five-year survival rate of 94.4%in responders and 45.5%in non-responders.Conclusion In this pilot study,we demonstrated that the LMP2-DCs vaccine is safe and effective in patients with NPC.Specific CTLs responses to LMP2 play a certain role in controlling and preventing the recurrence and metastasis of NPC,which warrants further clinical testing. | ZENG Yi SI Yong Feng LAN Gui Ping WANG Zhan ZHOU Ling TANG Min Zhong SJ O`Brien LAN Jiao ZHOU Xiang Yang WANG Yong Li TANG Juan ZHOU Zhi Xiang DU Hai Jun LIN Hui | 2020 | Biomedical and Environmental Sciences2020，33，11： | 2 |
| 13 | Target alignment in the Shen-Guang Ⅱ Upgrade laser facility显示文摘The Shen-Guang II Upgrade(SG-Ⅱ-U) laser facility consists of eight high-power nanosecond laser beams and one shortpulse picosecond petawatt laser. It is designed for the study of inertial confinement fusion(ICF), especially for conducting fast ignition(FI) research in China and other basic science experiments. To perform FI successfully with hohlraum targets containing a golden cone, the long-pulse beam and cylindrical hohlraum as well as the short-pulse beam and cone target alignment must satisfy tight specifications(30 and 20 μm rms for each case). To explore new ICF ignition targets with six laser entrance holes(LEHs), a rotation sensor was adapted to meet the requirements of a three-dimensional target and correct beam alignment. In this paper, the strategy for aligning the nanosecond beam based on target alignment sensor(TAS) is introduced and improved to meet requirements of the picosecond lasers and the new six LEHs hohlraum targets in the SG-II-U facility. The expected performance of the alignment system is presented, and the alignment error is also discussed. | Lei Ren Ping Shao Dongfeng Zhao Yang Zhou Zhijian Cai Neng Hua Zhaoyang Jiao Lan Xia Zhanfeng Qiao Rong Wu Lailin Ji Dong Liu Lingjie Ju Wei Pan Qiang Li Qiang Ye Mingying Sun Jianqiang Zhu Zunqi Lin | 2018 | High Power Laser Science and Engineering2018，6，1： | 2 |
| 14 | Structural and functional basis for pan-CoV fusion inhibitors against SARS-CoV-2 and its variants with preclinical evaluation显示文摘The COVID-19 pandemic poses a global threat to public health and economy.The continuously emerging SARS-CoV-2 variants present a major challenge to the development of antiviral agents and vaccines.In this study,we identified that EK1 and cholesterol-coupled derivative of EK1,EK1C4,as pan-CoV fusion inhibitors,exhibit potent antiviral activity against SARS-CoV-2 infection in both lung-and intestine-derived cell lines(Calu-3 and Caco2,respectively).They are also effective against infection of pseudotyped SARS-CoV-2 variants B.1.1.7(Alpha)and B.l.1.248(Gamma)as well as those with mutations in S protein,including N417T,E484K,N501Y,and D614G,which are common in South African and Brazilian variants.Crystal structure revealed that EK1 targets the HR1 domain in the SARS-CoV-2 S protein to block virus-cell fusion and provide mechanistic insights into its broad and effective antiviral activity.Nasal administration of EK1 peptides to hACE2 transgenic mice significantly reduced viral titers in lung and intestinal tissues.EK1 showed good safety profiles in various animal models,supporting further clinical development of EK1-based pan-CoV fusion inhibitors against SARS-CoV-2 and its variants. | Shuai Xia Qiaoshuai Lan Yun Zhu Chao Wang Wei Xu Yutang Li Lijue Wang Fanke Jiao Jie Zhou Chen Hua Qian Wang Xia Cai Yang Wu Jie Gao Huan Liu Ge Sun Jan Munch Frank Kirchhoff Zhenghong Yuan Youhua Xie Fei Sun Shibo Jiang Lu Lu | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 2 |
| 15 | Duplex Detection of Vibrio Cholerae and Vibrio Parahaemolyticus by Real-time Recombinase Polymerase Amplification显示文摘Vibrio cholerae and Vibrio parahaemolyticus are the two most commonly reported pathogens in seafood[1]. Consuming raw or undercooked seafood contaminated with these two Vibrio species can cause food poisoning, posing the risk of severe gastrointestinal illness and death[2-3]. Therefore,precise and reliable methods for detecting V. cholerae and V. parahaemolyticus contamination in seafood are essential for controlling food safety. | LIAO Lei SHI Wen MA Chao TANG Wen Lian QIAN Qi Lan WANG Yu LI Jiao Jiao SHEN Jin Yang JI Jing MA Jin Ming GAO Song | 2022 | Biomedical and Environmental Sciences2022，35，12： | 1 |
| 16 | Occupational solvent exposure,genetic variation of DNA repair genes,and the risk of non-Hodgkin's lymphoma显示文摘 | Jiao J Zheng T Lan Q | | 0，，： | 1 |
| 17 | Novel 6-bp Deletion Mutation in visfatin Gene and Its Associations with Birth Weight and Bodyweight in Chinese Cattle显示文摘Visfatin, like insulin, induces phosphorylation of signal transduction proteins that operatate downstream of the insulin receptor. The present study is focused on detecting deletion of visfatin gene and analyzing its effect on growth traits in six Chinese cattle breeds (Nangyang, Luxi, Qinchuan, Jiaxian Red, Grassland Red, and Chinese Holstein) using DNA sequencing, PCR-SSCP and PCR-RFLP methods. For the first time, a 6-bp deletion of visfatin was described and two alleles were revealed:W and D. The χ2-test analysis demonstrated that all breeds were in agreement with Hardy-Weinberg equilibrium (P>0.05). The associations of the novel 6-bp deletion of visfatin gene with growth traits of Nanyang cattle at 6-, 12-, 18-, and 24-mon-old were analyzed. Birth weight, 12- and 24-mon-old cattle with genotype WW had greater birth weight and average daily gain than genotype WD (P<0.01 or P<0.05). These results suggest that the deletion may influence the birth weight and bodyweight in 12 mon-old cattle. | WANG Mou ZHANG Ya YU Hui LAI Xin-sheng ZHU Jin-long JIAO Jin-zhen LAN Xian-yong LEI Chu-zhao ZHANG Liang-zhi CHEN Hong | 2012 | Journal of Integrative Agriculture2012，11，8： | 1 |
| 18 | Host immune responses of ducks infected with H5N1 highly pathogenic avian influenza viruses of different pathogenicities显示文摘 | Liangmeng Wei Peirong Jiao Yafen Song Lan Cao Runyu Yuan Lang Gong Jin Cui Shuo Zhang Wenbao Qi Su Yang Ming Liao | 2013 | Veterinary Microbiology2013，，： | 1 |
| 19 | Focus on the Development of Shale Gas in China-based on swot Analysis显示文摘 | ZHAO Xingang JIAO Li LAN Bei | | 0，，21： | 1 |
| 20 | Erratum to: Rapid generation of genetic diversity by multiplex CRISPR/Cas9 genome editing in rice显示文摘The same figure was misused for the PCR/RE assay results of Gn1a and GW2 fragments in Figure 3,and the arrows in the graphicsal result of GW2 were not on the tape.The corrected Figure 3 is as follows. | Lan Shen Yufeng Hua Yaping Fu Jian Li Qing Liu Xiaozhen Jiao Gaowei Xin Junjie Wang Xingchun Wang Changjie Yan Kejian Wang | 2019 | Science China(Life Sciences)2019，62，9： | 1 |
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