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| 1 | Management of hypersplenism in non-cirrhotic portal hypertension:a surgical series显示文摘BACKGROUND:Hypersplenism is commonly seen in patients with non-cirrhotic portal hypertension(NCPH).While a splenectomy alone can effectively relieve the hypersplenism,it does not address the underlying portal hypertension.The present study was undertaken to analyze the impact of shunt and non-shunt operations on the resolution of hypersplenism in patients with NCPH.The relationship of symptomatic hypersplenism,severe hypersplenism and number of peripheral cell line defects to the severity of portal hypertension and outcome was also assessed.METHODS:A retrospective analysis of NCPH patients with hypersplenism managed surgically between 1999 and 2009 at our center was done.Of 252 patients with NCPH,64(45 with extrahepatic portal vein obstruction and 19 with non-cirrhotic portal fibrosis) had hypersplenism and constituted the study group.Statistical analysis was done using GraphPad InStat.Categorical and continuous variables were compared using the chi-square test,ANOVA,and Student's t test.The MannWhitney U test and Kruskal-Wallis test were used to compare non-parametric variables.RESULTS:The mean age of patients in the study group was 21.81±6.1 years.Hypersplenism was symptomatic in 70.3% with an incidence of spontaneous bleeding at 26.5%,recurrent anemia at 34.4%,and recurrent infection at 29.7%.The mean duration of surgery was 4.16±1.9 hours,intraoperative blood loss was 457±126(50-2000) mL,and postoperative hospital stay 5.5±1.9 days.Following surgery,normalization of hypersplenism occurred in all patients.On long-term followup,none of the patients developed hepatic encephalopathy and 4 had a variceal re-bleeding(2 after a splenectomy alone,1 each after an esophago-gastric devascularization and proximal splenorenal shunt).Patients with severe hypersplenism and those with defects in all three peripheral blood cell lineages were older,had a longer duration of symptoms,and a higher incidence of variceal bleeding and postoperative morbidity.In addition,patients with triple cell line defects had elevated portal pressure(P=0.001),portal biliopathy(P=0.02),portal gastropathy(P=0.005) and intraoperative blood loss(P=0.001).CONCLUSIONS:Hypersplenism is effectively relieved by both shunt and non-shunt operations.A proximal splenorenal shunt not only relieves hypersplenism but also effectively addresses the potential complications of underlying portal hypertension and can be safely performed with good long-term outcome.Patients with hypersplenism who have defects in all three blood cell lineages have significantly elevated portal pressures and are at increased risk of complications of variceal bleeding,portal biliopathy and gastropathy. | Rajesh Rajalingam Amit Javed Dharmanjay Sharma Puja Sakhuja Shivendra Singh Hirdaya H Nag Anil K Agarwal | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，2： | 7 |
| 2 | Feature selection based on class-dependent densities for high-dimensional bi-nary data显示文摘 | JAVED K BABRI H A SAEED M | 2012 | IEEE Transactions on Knowledge and Data Engineering2012，24，3： | 1 |
| 3 | Skin cancer chemopreventive effects of a flavonoid antioxidant silymarin are mediate via impairment of receptor tyrosine kinase signaling and perturbation in cell cycle progression显示文摘 | GALI H JAVED S | 1998 | Biochem Biophys Res Commun1998，274，2： | 1 |
| 4 | Edaravone ameliorates oxi- dative stress associated eholinergic dysfunction and limits apoptotic response following focal cerebral ischemia in rat显示文摘 | Abmad A Khan MM Javed H | 2012 | Mol Cell Bio- ehem2012，367，12： | 1 |
| 5 | Rutin prevents cog- nitiv impairments by ameliorating oxidative stress and neu- roinflammation in rat model of sporadic dementia of Alzheimer typd显示文摘 | JAVED H KHAN M M AHMAD A | 2012 | Journal of Neuroscienee2012，210，： | 1 |
| 6 | Syndrome of cerebrospinal fluid hypovolemia following lumbar puncture cerebrospinal fluid leak in a patient with idiopathic intracranial hypertension 显示文摘 | Koul R Chacko A Javed H | 2002 | J Child Neurol2002，17，1： | 1 |
| 7 | Edaravone amel- iorates oxidative stress associated cholinergic dysfunction and limits apoptotic response following focal cerebral ischemia in rat 显示文摘 | Ahmad A Khan M M Javed H | 2012 | Mol Cell Biochem2012，367，12： | 1 |
| 8 | Non-carboxylic ana- logues of naproxen: Design, synthesis, and pharmaco- logical evaluation of some 1,3,4-oxadiazol thiadiazole and 1,2,4-triazole derivatives 显示文摘 | Amir M Kumar H Javed S A | 2007 | Arch Pharm2007，340，11： | 1 |
| 9 | Syndrome of cerebrospinal fluidhypovolemia following lumbar puncture cerebrospinal fluid leak in apatient with idiopathic intracranial hypertension显示文摘 | Koul R Chacko A Javed H | 2002 | J Child Neurol2002，17，1： | 1 |
| 10 | Improve-ment of Aspergillus oryzae for hyperproduction of endoglu-canase: expression cloning of cmc - 1 gene of Aspergillusaculeatus 显示文摘 | Rashid M H Javed M R Kawaguchi T | 2008 | Biotechnol Lett2008，30，12： | 1 |
| 11 | Effect of spacer length of alkanediyl - a, to - bis ( dimethylcetylammonium bromide) gemini homologues on the interfacial and physicochemical properties of BSA显示文摘 | MOHAMMADO A M JAVEED M K RIZWAN H K | 2010 | Colloids and Surfaces B : Biointerfaces2010，77，1： | 1 |
| 12 | Edaravone amel- iorates oxidative stress associated cholinergic dysfunction and limits apoptotic response following focal cerebral is- chemia in rat显示文摘 | Ahmad A Khan M M Javed H | 2012 | Mol Cell Biochem2012，367，12： | 1 |
| 13 | Numerical simulation of turbulent batch mixing in a vessel agitated by a Rushton turbine 显示文摘 | JAVED K H MAHMUD T ZHU J M | 2006 | Chemical Engineering and Processing2006，45，： | 1 |
| 14 | Piperine suppresses cerebral ischemia-reperfusion-induced inflammation through the repression of COX-2,NOS-2,and NF-kappaB in middle cerebral artery occlusion rat model显示文摘 | VAIBHAV K SHRIVASTAVA P JAVED H | 2012 | Mol Cell Biochem2012，367，： | 1 |
| 15 | Prediction and measurement of pollutant emissions in CNG fired internal combustion engine显示文摘In the present study, the detailed reaction mechanisms were developed and Chemkin 4.1.1 was implemented to predict the formation of pollutant species in compressed natural gas (CNG) fired internal combustion (IC) engine. The proposed mechanisms were developed by coupling the EXGAS (an automatic mechanism generation tool for alkane oxidation) mechanisms with the Leed's NOx mechanism (version 2.0). The simulation results of each proposed mechanism were validated by the experimental measurements for profiles of temperature, pressure and pollutant species (CO, NOx). The rate of production analysis of each mechanism identified the important reactions in each mechanism which contributed to the formation of pollutant species. In spite of some discrepancies, the experimental measurements indicate that Mechanism-IV (consisting of 208 reactions and 78 species) showed closer agreement for each of the predicted profiles of temperature, pressure and pollutant species (CO, NOx). | M. Mansha A. R. Saleemt Javed S. H Badar M. Ghauri | 2010 | Journal of Natural Gas Chemistry2010，19，5： | 1 |
| 16 | Syndrome of cerebrospinalfluid hypovolemia following lumbarpuncture cerebrospinal fluid leak in a patient with idiopat hic int racranial hypertension显示文摘 | Koul R Chacko A Javed H | 2002 | J Child Neurol2002，17，： | 1 |
| 17 | Eight-year study of children status epilepticus: midazolam infusion in management and outcome显示文摘 | Koul R Chako A Javed H | 2002 | J child neurol2002，17，2： | 1 |
| 18 | Trapping of Ce electrons in band gap and room temperature ferromagnetism of Ce4+ doped ZnO nanowires 显示文摘 | Javed I Liu X F Zhu H C | 2009 | J Appl Phys 1062009，08，3515108351： | 1 |
| 19 | Tumor necrosis factor-alpha antibody eluting stents reduce vascular smooth muscle cell proliferation in saphenous vein organ culture显示文摘 | Javed Q Swanson N Vohra H | 2002 | Exp Mol Pathol2002，73，2： | 1 |
| 20 | Characterizations of Semirings by p-injective and Projective Semimodules显示文摘 | AHSAN Javed SHABIR M WEINERT H J | 1998 | Communications in Algebra1998，26，7： | 1 |
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