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| 1 | Seminal biomarkers for the evaluation of male infertility显示文摘为努力与他们的搭挡一起怀孕的男人,诊断工具被限制并且经常由仅仅标准精液分析组成。这基线测试用作男富饶的一个粗略的评价,离开需要另外的诊断 biomarkers 的病人和临床医生。精液从因此,这评论在某些男不孕情形在当前、新奇的精液的 biomarkers 上集中包括自然富饶,区分精子缺乏病原学,并且预言的繁殖的腺帮助了的男性包含分子的最高的集中繁殖技术成功。当前可得到的测试包括 antisperm 抗体试金, DNA 破碎索引,在 situ 杂交的精子荧光,和另外的历史的精子功能的测试。当前的试金的差的诊断能力导致了继续的努力发现更预兆的 biomarkers。genomics, epigenetics, proteomics, transcriptomics,和为新奇男不孕 biomarkers 的发展的 metabolomics 抓住诺言的地里的新兴的研究。TEX101, ECM1,和 ACRV1 的精液的基于蛋白质的试金已经是可得到的或在为临床的使用的最后的开发中。当我们试图理解男不孕的 pathophysiologic 过程, DNA, RNA,蛋白质,或代谢物的另外的面板正在被探索。未来冒险将需要继续数据集成和确认让临床上有用的不孕 biomarkers 的开发帮助男不孕诊断,处理,并且建议。 | Jared M Bieniek Andrei P Drabovich Kirk C Lo | 2016 | Asian Journal of Andrology2016，18，3： | 15 |
| 2 | Platelet-rich plasma for muscle injuries: A systematic review of the basic science literature显示文摘BACKGROUND Platelet-rich plasma(PRP) is an increasingly used biologic adjunct for muscle injuries, as it is thought to expedite healing. Despite its widespread use, little is known regarding the mechanisms by which PRP produces its efficacious effects in some patients.AIM To clarify the effects of PRP on muscular pathologies at the cellular and tissue levels by evaluating the basic science literature.METHODS A systematic review of PubMed/MEDLINE and EMBASE databases was performed using the Preferred Reporting Items for Systematic Reviews and MetaAnalyses(PRISMA) guidelines and checklist. Level III in vivo and in vitro studies examining PRP effects on muscles, myocytes and/or myoblasts were eligible for inclusion. Extracted data included PRP preparation methods and study results.RESULTS Twenty-three studies were included(15 in vivo, 6 in vitro, 2 in vitro/in vivo). Only one reported a complete PRP cytology(platelets, and red and white blood cell counts). Five in vitro studies reported increased cellular proliferation, four reported increased gene expression, and three reported increased cellular differentiation. Five in vivo studies reported increased gene expression, three reported superior muscle regeneration, and seven reported improved histological quality of muscular tissue.CONCLUSION The basic science literature on the use of PRP in muscle pathology demonstrates that PRP treatment confers several potentially beneficial effects on healing in comparison to controls. Future research is needed to determine optimal cytology,dosing, timing, and delivery methods of PRP for muscle pathologies. | Kyle N Kunze Charles P Hannon Jared D Fialkoff Rachel M Frank Brian J Cole | 2019 | World Journal of Orthopedics2019，10，7： | 6 |
| 3 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 4 | CD133 expression is not restricted to stem cells, and both CD133^sup +^ and CD133^sup -^ metastatic colon cancer cells initiate tumors显示文摘 | Shmelkov Sergey V Butler Jason M Hooper Andrea T Hormigo Adilia Kushner Jared Milde Till Clair Ryan St Baljevic Muhamed White Ian Jin David K Chadburn Amy Murphy Andrew J Valenzuela David M Gale Nicholas W Thurston Gavin Yancopoulos George | 2008 | Journal of Clinical Investigation2008，，： | 2 |
| 5 | Preclinical and clinical evaluations of ABX-EGF, a fully human anti-epidermal growth factor receptor antibody显示文摘 | Kenneth A Foon Xiao-Dong Yang Louis M Weiner Arie S Belldegrun Robert A Figlin Jeffrey Crawford Eric K Rowinsky Janice P Dutcher Nicholas J Vogelzang Jared Gollub John A Thompson Garry Schwartz Ronald M Bukowski Lorin K Roskos Gisela M Schwab | 2004 | International Journal of Radiation Oncology Biology Physics2004，，3： | 1 |
| 6 | Off - pump versus on - pump coronary artery surgery显示文摘 | JARES M VANEK T BEDNAR F | 2007 | Int Heart J2007，48，1： | 1 |
| 7 | Gene expression profiling of acute myeloid leukemia wit h t ranslocation t ( 8 ; 16 ) (p11 ; p13 ) and MYST3- CREBBP rearrangement reveals a distinctive signature with a specific pattern of HOX gene expression显示文摘 | Camos M Esteve J Jares P | 2006 | Cancer Res2006，66，14： | 1 |
| 8 | Localization,ion channel regulation,and genetic interactions during abscisic acid signaling of the nuclear mRNA cap-binding protein ABH1显示文摘 | VERONIGUE H YOSHIYUKI M JARED J Y | 2002 | Plant Physiology2002，130，： | 1 |
| 9 | Recognising symmetry in solid models 显示文摘 | Tate S J Jared G E M | 2003 | Computer-Aided Design2003，35，7： | 1 |
| 10 | Tranexamic acid reduces bleeding after off-pump coronary artery bypass grafting显示文摘 | Jares M Vanek T Straka Z | 2003 | J Cardiovasc Surg (Torino)2003，44，2： | 1 |
| 11 | Fibrinolytic inhibitors in off pump coronary surgery: a prospective, randomized double blind TAP study (tranexamic acid, aprotinin, pla cebo) 显示文摘 | Vanek T jares M Fajt R | 2005 | Eur J Cardio-Thoracic Sur2005，28，4： | 1 |
| 12 | Gene expression profiling of acute myeloid leukemia with translocation t (8: 16) (p11; p13) and MYST3 CREBBP rearrangement reveals a distinctive signature with a specific pattern of HOX gene expression 显示文摘 | Camos M Esteve J Jares P | 2006 | CancerRes2006，66，14： | 1 |
| 13 | Tranexamic acid re- duces bleeding after off-pump coronary artery bypass grafting显示文摘 | Jares M Vanek T Straka Z | 2003 | J Cardiovasc Sur2003，44，2： | 1 |
| 14 | A molecular phylogenetic analysis of strombid gastropod morphological diversity 显示文摘 | JARED M L MICHAEL S T KAUSTUV R | 2006 | Molecular Phylogenetics and Evolution2006，41，： | 1 |
| 15 | p21^(WAF/CIP1) expression is associated with cell differentiation but not with p53 mutations in squamous cell carcinoma of Larynx显示文摘 | Nodal A Jares P Cazorl M | 1997 | Pathology1997，183，2： | 1 |
| 16 | Preclinical and clinical evaluations of ABX-EGF, a fully human anti-epidermal growth factor receptor antibody显示文摘 | Kenneth A Foon Xiao-Dong Yang Louis M Weiner Arie S Belldegrun Robert A Figlin Jeffrey Crawford Eric K Rowinsky Janice P Dutcher Nicholas J Vogelzang Jared Gollub John A Thompson Garry Schwartz Ronald M Bukowski Lorin K Roskos Gisela M Schwab | 2004 | International Journal of Radiation Oncology, Biology, Physics2004，，3： | 1 |
| 17 | p21WAF1/Cisp1 is associated with cyclinD1CCND1 expression and tubular differentiation but is independent of p53 overexpression in human breast carcinoma显示文摘 | FERNANDEZ P L JARES P | 1998 | J Pathol1998，184，3： | 1 |
| 18 | Sitosterol 3-o-β-d-glucu-ronopyranoside from Senecio bonariensis显示文摘 | JARES E A TETTAMANZI M C POMIUO A B | 1990 | Phytochemistry1990，29，1： | 1 |
| 19 | Resistivity Imaging of Electrokinetic Transport in Soil显示文摘 | L Jared West Douglas I Stewart Andrew M Binley | 1997 | Journal of Geoenvironmental engineering ASCE1997，61，4： | 1 |
| 20 | Homophone effects in lexical decision显示文摘 | Pexman P M Luper S J Jared D | 2001 | Journal of Experimental Psychology:Learning Memory and Cognition2001，27，： | 1 |
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