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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Machine learning models compared to existing criteria for noninvasive prediction of endoscopic retrograde cholangiopancreatography-confirmed choledocholithiasis显示文摘Background and aims:Noninvasive predictors of choledocholithiasis have generally exhibited marginal performance characteristics.We aimed to identify noninvasive independent predictors of endoscopic retrograde cholangiopancreatography(ERCP)-confirmed choledocholithiasis and accordingly developed predictive machine learning models(MLMs).Methods:Clinical data of consecutive patients undergoing first-ever ERCP for suspected chol-edocholithiasis from 2015 to 2019 were abstracted from a prospectively-maintained database.Multiple logistic regression was used to identify predictors of ERCP-confirmed choledocholithiasis.MLMs were then trained to predict ERCP-confirmed choledocholithiasis using pre-ERCP ultrasound(US)imaging only as well as using all available noninvasive imaging(US,computed tomography,and/or magnetic reso-nance cholangiopancreatography).The diagnostic performance of American Society for Gastrointestinal Endoscopy(ASGE)“high-likelihood”criteria was compared to MLMs.Results:We identified 270 patients(mean age 46 years,62.2%female,73.7%Hispanic/Latino,59%with noninvasive imaging positive for choledocholithiasis)with native papilla who underwent ERCP for suspected choledocholithiasis,of whom 230(85.2%)were found to have ERCP-confirmed chol-edocholithiasis.Logistic regression identified choledocholithiasis on noninvasive imaging(odds ratio(OR)¼3.045,P¼0.004)and common bile duct(CBD)diameter on noninvasive imaging(OR¼1.157,P¼0.011)as predictors of ERCP-confirmed choledocholithiasis.Among the various MLMs trained,the random forest-based MLM performed best;sensitivity was 61.4%and 77.3%and specificity was 100%and 75.0%,using US-only and using all available imaging,respectively.ASGE high-likelihood criteria demonstrated sensitivity of 90.9%and specificity of 25.0%;using cut-points achieving this specificity,MLMs achieved sensitivity up to 97.7%.Conclusions:MLMs using age,sex,race/ethnicity,presence of diabetes,fever,body mass index(BMI),total bilirubin,maximum CBD diameter,and choledocholithiasis on pre-ERCP noninvasive imaging predict ERCP-confirmed choledocholithiasis with good sensitivity and specificity and outperform the ASGE criteria for patients with suspected choledocholithiasis. | Camellia Dalai John M Azizian Harry Trieu Anand Rajan Formosa C Chen Tien Dong Simon W Beaven James H.Tabibian | 2021 | Liver Research2021，5，4： | 3 |
| 3 | Modulation of β-lactam resistance in Staphylococcus aureus by catechins and gallates显示文摘 | Paul D Stapleton Saroj Shah James C Anderson Yukihiko Hara Jeremy M.T Hamilton-Miller Peter W Taylor | 2004 | International Journal of Antimicrobial Agents2004，，5： | 2 |
| 4 | Insulin resistance is associated with chronic hepatitis C and virus infection fibrosis progression显示文摘 | Jason M Hui Archana Sud Geoffrey C Farrell Priyanka Bandara Karen Byth James G Kench Geoffrey W McCaughan Jacob George | 2003 | Gastroenterology2003，，6： | 2 |
| 5 | Progress in structural materials for aerospace systems 显示文摘 | James C W Edgar A S | 2003 | Acta Materialia2003，51，： | 1 |
| 6 | Boron toxicity and deficiency: A Review 显示文摘 | U C Gupta Y W Jame C A Campbell | 1985 | Canadian Journal of Soil Science1985，65，3： | 1 |
| 7 | Determination of morphine and related alkaloids in crude morphine , poppy straw and opium preparations by micellar electrokinetic capil-lary chromatography显示文摘 | TRENERRY C V ROBERT J W JAMES R | 1995 | Journal of Chromatography A1995，，718： | 1 |
| 8 | Comprehensive, quantitative, congener-specific analysis of eight aroclors and complete PCB congener assignments 显示文摘 | George M F Robert E W James C C | 1996 | Chernosphere1996，33，： | 1 |
| 9 | Cotton α-globulin promoter:isolation and functional characterization in transgenic cotton,Arabidopsis,and tobacco 显示文摘 | Sunilkumar Ganesan Connell James P Smith C W | 2002 | Transgenic Research2002，11，： | 1 |
| 10 | Short - channel effects and drain - induced barrier lowering in nanometerscale GaAs MESFET's 显示文摘 | James A Adams Thayne I G Wilkinson C D W | 1993 | IEEE Trans Electron Devices1993，40，6： | 1 |
| 11 | Scheduling Algorithms for multiprogramming in a hard-real-time environment显示文摘 | Liu C L James W | 1973 | Journal of the Association for Computing Machinery1973，20，： | 1 |
| 12 | Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation显示文摘 | LAM C W JAMES JT Mc CLUSKEY R | 2004 | Toxicol Sci2004，77，1： | 1 |
| 13 | Structural Equation Modeling in Practice:A Review and Recommended Two - Step Approach 显示文摘 | Anderson James C David W Gerbing | 1988 | Psychology Bulletin1988，103，3： | 1 |
| 14 | Pulmonary toxicity of single wall carbon nano-tubos in mice 7 and 90 days after intratracheal instillation显示文摘 | LAM C W JAMES J T MCCLUSKEY R | 2004 | Toxicological Sciences2004，77，1： | 1 |
| 15 | Feature-based re- verse engineering of mechanical parts 显示文摘 | THOMPSON W B OWEN J C JAMES H | 1999 | IEEE Transactions on Robotics and Automation1999，15，1： | 1 |
| 16 | Activated carbon as catalyst in certain oxidation-reduction显示文摘 | ELMER C L JAMES H W | 1940 | J Phys Chem1940，44，1： | 1 |
| 17 | Five-dimensional optical re-cording mediated by surface plasmons in gold nanorods显示文摘 | PETER Z JAMES W M C MIN G | 2009 | Na-ture2009，459，7245： | 1 |
| 18 | A preliminaty investigation of the organic chemical emissions from green sand pyrolysis显示文摘 | GWIN C H SCTT W D JAMES R H | 1976 | Am Ind Hyg Assoe J1976，37，： | 1 |
| 19 | Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation显示文摘 | Lam C W James J T McCluskey R | 2004 | Toxicological Sciences2004，77，： | 1 |
| 20 | The rheology of two-dimensional foams显示文摘 | Simon C Denis W James A G | 2004 | Rheol Acta2004，43，5： | 1 |
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