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| 1 | Regression of cardiovascular remodeling in hypertension:Novel relevant mechanisms显示文摘Asymptomatic organ damage due to progressive kidney damage, cardiac hypertrophy and remodeling put hypertensive patients at high risk for developing heart and renal failure, myocardial infarction and stroke. Current antihypertensive treatment normalizes high blood pressure, partially reverses organ damage, and reduces the incidence of heart and renal failure. Activation of the renin-angiotensin system(RAS) is a primary mechanism of progressive organ damage and, specifically, a major cause of both renal and cardiovascular fibrosis. Currently, inhibition of the RAS system [mainly with angiotensin I converting enzyme inhibitors or angiotensin II(Ang II) receptor antagonists] is the most effective antihypertensive strategy for normalizing blood pressure and preventing target organ damage. However, residual organ damage and consequently high risk for cardiovascular events and renal failure still persist. Accordingly, in hypertension, it is relevant to develop new therapeutic perspectives, beyond reducing blood pressure to further prevent/reduce target organ damage by acting on pathways that trigger and maintain cardiovascular and renal remodeling. We review here relevant novel mechanisms of target organ damage in hypertension, their role and evidence in prevention/regression of cardiovascular remodeling and their possible clinical impact as well. Specifically, we focus on the signaling pathway Rho A/Rho kinase, on the impact of the vasodilatory peptides from the RAS and some insights on the role of estrogens and myocardial chymase in cardiovascular hypertensive remodeling. | Jorge E Jalil María P Ocaranza | 2016 | World Journal of Hypertension2016，6，1： | 2 |
| 2 | Biocompatibility of Silica Coated Na YF4Upconversion Fluorescent Nanocrystal显示文摘 | Zhang Y Jalil R A | 2008 | Biomaterials2008，29，30： | 1 |
| 3 | IW ide therapeutic timewindow for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat显示文摘 | Candelario - JalilE Gonzalez - Falcon A Garcia - CabreraM | 2004 | Brain Res2004，1007，12： | 1 |
| 4 | The Impact of Growth, Energy and Financial Development on the Environment in China: A Coin- tegration Analysis 显示文摘 | Jalil A Feridun M | 2011 | Energy Economics2011，33，2： | 1 |
| 5 | Stability Analysis of Caputo Fractional-Order NonlinearSystems Revisited显示文摘 | HADI DEL A V ARI DUMITRU BALEANU JALIL SADATI | 2012 | Nonlinear Dynamics2012，67，4： | 1 |
| 6 | Allogeneic peripheral blood stem cell transplantation for hypereosinophilic syndrome with severe cardiac dysfunction 显示文摘 | Chockalingam A Jalil A Shadduck RK Lister J | 1999 | Bone Marrow Transplant1999，23，10： | 1 |
| 7 | Characterization of tungstophorie and supported on MCM- 41 meso porous sillca by using n- hexane cracking benzene adsorption and X- ray diffiraction显示文摘 | Jalil P A A Daous M A | 2001 | Appl Catal:A2001，207，12： | 1 |
| 8 | Effects of acidity on mineralization: pH2 dependence of organic matter mineralization in weakly acidic soils显示文摘 | Curtin D Campbell C A Jalil A | 1998 | Soil Biology and Biochemistry1998，30，： | 1 |
| 9 | Prevalence of helicobacter pylori infection in children, a population- based cross- sectional study in West Iran显示文摘 | JAFAR S JALIL A SOHEILA N | 2013 | Iran J Pediatr2013，23，1： | 1 |
| 10 | Long - run relationship between in- come inequality and financial development in China 显示文摘 | Jalil A Feridun M | 2011 | Journal of Asia Pacific Economy2011，16，2： | 1 |
| 11 | Environment Kuznets curve for CO2 emissions: acointegration analysis for China显示文摘 | JALIL A MAHMUD S F | 2009 | En- ergy Policy2009，37，7： | 1 |
| 12 | Induced flow for ventilation and cooling by a solar chimney显示文摘 | Imran A A Jalil J M Ahmed S T | 2015 | Renewable Energy2015，78，： | 1 |
| 13 | Environment Kuznets curve for CO2 emissions: a cointegration analysis for China 显示文摘 | Jalil A Mahmud S F | 2009 | Energy Policy2009，37，12： | 1 |
| 14 | Excitable gap composition in the presence of antiarrhythmic drugs in common human atrial flutter显示文摘 | Jalil E Mensour B Vinet A | 2003 | Can J Cardiol2003，19，3： | 1 |
| 15 | Attenuation of cardiac hypertrophy in carnitine-deficient juveniIe visceral steatosis(JVS)mice achieved by lowering dietary lipid显示文摘 | Jalil M A Horiuchi M Wakamatsu M | 2006 | J Biochem2006，39，2： | 1 |
| 16 | Environment Kuznets curve for CO2 emis- sions:A eointegration analysis for China显示文摘 | Jalil A Mahmud S F | 2009 | Energy Policy2009，，12： | 1 |
| 17 | Effects of acidity on mineralization:pH-dependence of organic matter mineralization in weakly acidic soils显示文摘 | CURTIN D CAMPBELL C A JALIL A | | 0，，30： | 1 |
| 18 | Effects of acidity on mineralization : pH-dependence of organic matter mineralization in weakly acidic soils显示文摘 | Curtin D Campbell C A Jalil A | 1998 | Soil Biology and Biochemistry1998，30，1： | 1 |
| 19 | Does Non-farm income improve the poverty and income inequality among agricultural household in rural Kedah? 显示文摘 | MAT S H JALIL A HARUN M | 2012 | Procedia Economics and Finance2012，，1： | 1 |
| 20 | Prion protein prevents human breast carcinoma cell line from tumor necro- sis factorot - induced cell death 显示文摘 | DIARRA - MEHRPOUR M ARRABAL S JALIL A | 2004 | Cancer Res2004，64，2： | 1 |
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