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| 1 | A 24 hour naproxen dose on gastrointestinal distress and performance during cycling in the heat显示文摘Using a double-blind,randomized and counterbalanced,cross-over design,we assessed naproxen's effects on gastrointestinal(GI)distress and performance in eleven volunteers(6 male,5 female).Participants completed 4 trials:1)placebo and ambient);2)placebo and heat;3)naproxen and ambient;and 4)naproxen and heat.Independent variables were one placebo or 220 mg naproxen pill every 8 h(h)for 24 h and ambient(22.7±1.8℃)or thermal environment(35.7±1.3℃).Participants cycled 80 min at a steady heart rate then 10 min for maximum distance.Perceived exertion was measured throughout cycling.Gastrointestinal distress was assessed pre-,during,post-,3 h post-,and 24 h post-cycling using a GI index for upper,lower,and systemic symptoms.No statistically significant differences occurred between conditions at any time for GI symptoms or perceived exertion,distance,or heart rate during maximum effort.A 24 h naproxen dose did not significantly affect performance or cause more frequent or serious GI distress when participants were euhydrated and cycling at moderate intensity in a thermal environment. | Dawn M.Emerson J.Mark Davis Stephen CL.Chen Toni M.Torres-McGehee Craig E.Pfeifer Charles C.Emerson Joseph D.Bivona Justin V.Stone | 2020 | Sports Medicine and Health Science2020，2，1： | 0 |
| 2 | Glycemic variability:Importance,relationship with physical activity,and the influence of exercise显示文摘Glycemic variability is a more sensitive assessment of glycemic health as opposed to traditional clinical mea-surements.It considers all blood glucose concentrations over a given period to better account for glucose oscil-lations that occur and provides clinicians with insight into how individuals regulate and/or maintain their glycemic health.The advancement of continuous glucose monitoring(CGM)allows for the measurement of free-living glucose concentrations while providing a more reliable assessment of treatment of dysregulated glycemic.CGM coupled with management of lifestyle behavioral factors,such as reduced sedentary behavior and increased physical activity and regular exercise,potentially offers a previously untapped method for promoting improved glycemic health through greater regulation of glucose concentrations.The aim of this review is to critically evaluate the evidence regarding the measurement of glycemic variability and summarize the current under-standing of the relationship between glycemic variability,sedentary behavior,physical activity,the influence of a single exercise session or repeated exercise sessions,and exercise training.This review considers information pertaining to the strengths and limitations for measuring glycemic variability and provides insight into future study designs aimed at evaluating the relationship between sedentary behavior and physical activity with,as well as the influence of exercise on,glycemic variability as a primary outcome. | Joshua R.Sparks Erin E.Kishman Mark A.Sarzynski J.Mark Davis Peter W.Grandjean J.Larry Durstine Xuewen Wang | 2021 | Sports Medicine and Health Science2021，3，4： | 0 |
| 3 | An acute naproxen dose does not affect core temperature or Interleukin-6 during cycling in a hot environment显示文摘Non-steroidal anti-inflammatory drugs’anti-pyretic and anti-inflammatory effects has led some individuals to theorize these medications may blunt core body temperature(Tc)increases during exercise.We utilized a double-blind,randomized,and counterbalanced cross-over design to examine the effects of a 24-h naproxen dose(3–220 mg naproxen pills)and placebo(0 mg naproxen)on Tc and plasma interleukin-6(IL-6)concentrations during cycling in a hot or ambient environment.Participants(n=11;6 male,5 female;age=27.8±6.5 years,weight=79.1±17.9 kg,height=177±9.5 cm)completed 4 conditions:1)placebo and ambient(Control);2)placebo and heat(Heat);3)naproxen and ambient(Npx);and 4)naproxen and heat(NpxHeat).Dependent measures were taken before,during,and immediately after 90 min of cycling and then 3 h after cycling.Overall,Tc significantly increased pre-(37.1±0.4℃)to post-cycling(38.2±0.3℃,F_(1.7,67.3)=150.5,p<0.001)and decreased during rest(37.0±0.3℃,F_(2.0,81.5)=201.6,p<0.001).Rate of change or maximum Tc were not significantly different between conditions.IL-6 increased pre-(0.54±0.06 pg/ml)to post-exercise(2.46±0.28 pg/ml,p<0.001)and remained significantly higher than pre-at 3 h post-(1.17±0.14 pg/ml,95%CI=-1.01 to-0.23,p=0.001).No significant IL-6 differences occurred between conditions.A 24-h,over-the-counter naproxen dose did not significantly affect Tc or IL-6 among males and females cycling in hot or ambient environments. | Dawn M.Emerson Stephen CL.Chen Toni M.Torres-McGehee Craig E.Pfeifer Charles C.Emerson J.Mark Davis | 2021 | Sports Medicine and Health Science2021，3，4： | 0 |
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