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| 1 | Double negative T cells,a potential biomarker for systemic lupus erythematosus显示文摘Systemic lupus erythematosus(SLE)is an autoimmune disease that is a challenge to diagnose and treat.There is an urgent need for biomarkers to help define organ involvement,and more effective therapies.A unique population of T cells,the CD3^(+)CD4^(−)CD8^(−)(DNeg)cells,is significantly increased in lupus patients.Twentyseven cases(53%)of pediatric SLE patients had elevated DNeg cells in their peripheral blood,which correlated with kidney function(R^(2)=0.54).Significant infiltration of DNeg cells was observed in both adult and pediatric lupus kidneys by immunofluorescence.For the first time,this study provides direct evidence that DNeg cells facilitate kidney injury in preclinical 8-week-old MRL/lpr lupus mice.In lupus mice,the increase in DNeg cells tracked with worsening disease and correlated with kidney function(R^(2)=0.85).Our results show that DNeg cells per se can cause kidney dysfunction,increase in number with increase in disease pathology,and could serve as a potential biomarker. | Jessy J.Alexander Alexander Jacob Anthony Chang Richard J.Quigg James N.Jarvis | 2020 | Precision Clinical Medicine2020，3，1： | 4 |
| 2 | 家禽流感的历史显示文摘高致病型禽流感 (HPAI)是最早发现的病毒性疾病之一 ,在十九、二十世纪之交 ,几个研究小组证实了其病原因子是超过滤性微生物。 | 周宗清 Dennis J.Alexander | 2001 | 国外畜牧学(猪与禽)2001，，2： | 4 |
| 3 | 现代纺丝设备中的添加剂注入和混合显示文摘纺丝线产量正越来越大.新近安装的聚酯纺丝线大多直接连接在一个共同的反应器上.这种工艺线虽然经济,但相比挤出机其纺丝线、产品灵活性非常有限,而添加剂注入和混合系统可以帮助重新获得失去的灵活性.
1 添加剂注入和混合
应用添加剂注入和混合系统,母粒和添加剂可以在反应器和纺丝位之间任意位置加入熔体管道. | F.Dickmeiβ J.Alexander 杨铖 | 2014 | 国际纺织导报2014，42，2： | 4 |
| 4 | 禽流感病毒对人类的威胁有多大显示文摘A型流感病毒的自然感染已在多种动物有所报道 ,包括人、猪、马、海洋哺乳动物和鸟类等动物。这种破坏性传染病有时发生于人类。尽管从哺乳动物中只分离到较少的HA和NA亚型组合病毒 ,但是在鸟类中分离到了大部分HA和NA亚型组合。 | 许峰 Dennis J.Alexander | 2001 | 国外畜牧学(猪与禽)2001，，4： | 1 |
| 5 | Muscle, myeloid cells, and complement: a complex interaction显示文摘The complement system is a critical arm of the immune system that plays an important role not only in maintaining health but also contributes to disease.Complement activation generates biologically active products C3a and C5a,which are important links between complement and cellular immunity.Recent studies have revealed that C5a/C5aR signaling is critical in both humoral and inflammatory responses,resulting in functional renal insufficiency in immune complex-mediated glomerulonephritis.1 Consistent with these studies and considering the complexity of complement system interactions based on location and setting,a recent article by Zhang et al.2 has shed light on C3a/C3aR signaling as the link that regulates monocyte function and trafficking and facilitates skeletal muscle regeneration.This commentary highlights the important themes originating from the work described,which include the following:(1)complement C3 depletion reduced muscle regeneration,(2)C3a signaling through its G-coupled receptor C3aR facilitated muscle regeneration by regulating monocyte/macrophage infiltration through CCL5,and(3)C5a/C5aR signaling does not affect monocyte/macrophage infiltration in this particular setting. | Jessy J.Alexander Richard J.Quigg | 2018 | Cellular & Molecular Immunology2018，15，11： | 1 |
| 6 | Sexual isolation and extreme morphological divergence in the Cumaná guppy: a possible case of incipient speciation显示文摘 | H. J.Alexander F.Breden | 2004 | Journal of Evolutionary Biology2004，，6： | 1 |
| 7 | Comparison of polysaccharide iron complexes used as iron supplements显示文摘 | Emma M. Coe Lawrence H. Bowen J.Alexander Speer Robert D. Bereman | 1995 | Journal of Inorganic Biochemistry1995，，4： | 1 |
| 8 | 南阿巴拉契亚山脉阿勒格尼期侵入体的生成、分离、上升和侵位显示文摘石炭-二叠纪的阿勒格尼造山运动在南阿巴拉契亚产生一次独特的、持续达45百万年的侵入事件,形成一条分散的NE向侵入岩带。岩体总面积10500km^2,其中75%为下地亮源的偏铝质黑云母花岗岩类或角闪黑云花岗岩类,20%为来自较演化壳源的过铝质黑云母+白云母±石榴石或堇青石+黑云母花岗岩类,余下5%为辉长岩、中性岩或可能存在的碱性花岗岩。花岗岩类与中基性岩的面积比为180:1。出露的侵入岩以较慢的速率——2km^3/线性公里/百万年沿造山带产生,表明源岩不能产生较多的熔体或低效的熔融机制或岩浆分离、上升较为困难。侵入岩在岩石成分和侵位年龄上缺乏空间趋势,总量较少但花岗岩类相对丰富,以及与同时的平移断层空间上吻合,这些都有助于表明变形作用促使花岗岩浆产生、分离和上升。熔融的发生是借助于高温岩石与低温熔融岩石的并置、减压、助熔等机制或它们的综合,而这些机制又是扭压穹拱作用或断层作用的结果。岩浆因扩容作用被吸入活动剪切带而与其源岩分离。从能量的角度考虑,岩浆多半在断层带中呈管流上升,同时各次岩浆脉动都贯入同一个预热通道中并上升,导致形成常见的复式岩体。岩浆侵位限于断层和褶皱中的拉张区或最小挤压区。远离剪切带的岩体可能在其最后阶段由韧性气球膨胀作用侵位。 | J.Alexander Speer 肖志发 | 1995 | 国外花岗岩类地质与矿产1995，，4： | 0 |
| 9 | 用聚合物和标样粉尘进行过滤试验显示文摘在设计聚合物加工工艺设备的时候,过滤日益被看作是不可缺少的过程.但过滤的同时,也给整个工艺过程带来了不希望有的影响,过滤会引起压力下降,并增加聚合物停留时间.因此,过滤器的设计应协调压力降、停留时间及使用寿命三者间的关系.同时,过滤介质也起着重要作用. | R.Wnuk J.Alexander 闵惠玲 | 1997 | 国际纺织导报1997，0，4： | 0 |
| 10 | 中国沿海城市应对气候风险发展策略概述显示文摘本文首先阐述了气候风险给沿海城市带来的挑战及中国沿海城市面临的气候风险,进一步分析了影响城市气候安全的6个关键要素,包括城市设计、交通系统、能源系统、建筑、水系统和固体废弃物管理系统,并在此基础上,为中国沿海城市的气候安全发展提出适应性策略。 | 张媛媛 刘江 高莉洁 J.Alexander Schmidt | 2017 | 城市建筑2017，0，21： | 0 |
| 11 | 在切换过程中排气对连续高聚物过滤器的影响显示文摘两年前Barmag公司开始研究一种新的连续过滤器在纤维纺丝线上的应用。这种纺丝线通常纵向安装即挤出机在顶层,卷绕机在底层。到目前为止,具有水平排列滤芯的过滤器可方便地安装在纺丝线的挤出机之后。 | J.Alexander K.schfer 陆琰 | 1998 | 国际纺织导报1998，0，2： | 0 |
| 12 | Subnanometer localization accuracy in widefield optical microscopy显示文摘The common assumption that precision is the limit of accuracy in localization microscopy and the typical absence of comprehensive calibration of optical microscopes lead to a widespread issue—overconfidence in measurement results with nanoscale statistical uncertainties that can be invalid due to microscale systematic errors.In this article,we report a comprehensive solution to this underappreciated problem.We develop arrays of subresolution apertures into the first reference materials that enable localization errors approaching the atomic scale across a submillimeter field.We present novel methods for calibrating our microscope system using aperture arrays and develop aberration corrections that reach the precision limit of our reference materials.We correct and register localization data from multiple colors and test different sources of light emission with equal accuracy,indicating the general applicability of our reference materials and calibration methods.In a first application of our new measurement capability,we introduce the concept of critical-dimension localization microscopy,facilitating tests of nanofabrication processes and quality control of aperture arrays.In a second application,we apply these stable reference materials to answer open questions about the apparent instability of fluorescent nanoparticles that commonly serve as fiducial markers.Our study establishes a foundation for subnanometer localization accuracy in widefield optical microscopy. | Craig R.Copeland Jon Geist Craig D.McGray Vladimir A.Aksyuk J.Alexander Liddle B.Robert Ilic Samuel M.Stavis | 2018 | Light(Science & Applications)2018，7，1： | 0 |
| 13 | Effect of arsenic contaminated irrigation water on Lens culinaris L.and toxicity assessment using lux marked biosensor显示文摘Contamination of irrigation water represents a major constraint to Bangladesh agriculture,resulting in elevated levels in the terrestrial systems.Lux bacterial biosensor technology has previously been used to measure the toxicity of metals in various environmental matrices.While arbuscular mycorrhizal fungi have their most significant effect on phosphorus uptake,but showed alleviated metal toxicity to the host plant.The study examined the effects of arsenic and inoculation with an arbuscular mycorrhizal fungus,Glomus mosseae,on lentil (Lens culinaris L.cv.Titore).Plants were grown with and without arbuscular mycorrhizal inoculum for 9 weeks in a sand and terra-green mixture (50:50,V/V) and watered with five levels of arsenic (0,1,2,5,10 mg As/L arsenate).The results showed that arsenic addition above 1 mg/L significantly reduced percentage of mycorrhizal root infection.On further analysis a close relationship was established with the vegetative and reproductive properties of lentil (L.culinaris) plants compared to the percentage bioluminescence of the soil leachate.However,arbuscular mycorrhizal fungal inoculation reduced arsenic concentration in roots and shoots.Higher concentrations of arsenic (5,10 mg As/L arsenate) reduced the mycorrhizal efficiency to increase phosphorus content and nitrogen fixation.Therefore,this study showed that increased concentration of arsenic in irrigation water had direct implications to the lentil (L.culinaris) plants overall performance.Moreover the use of bioassay demonstrated that mycorrhiza and clay particle reduced arsenic bioavailability in soil. | F.R.Sadeque Ahmed Ian J.Alexander Mwinyikione Mwinyihija Ken Killham | 2012 | Journal of Environmental Sciences2012，24，6： | 0 |
| 14 | Optical coherence tomography in optic disc drusen显示文摘Optic disc drusen (ODD) are hyaline deposits in the optic nerve head, occurring in approximately 2% of the population. ODD may be superficial and visible, or buried and either invisible or seen only as elevation of the optic disc, mimicking optic disc edema. Advanced optic nerve imaging, including optical coherence tomography (OCT) can be used to diagnose and characterize ODD with very high resolution. Enhanced depth imaging (EDI-OCT) in particular has emerged as the optimal modality to directly visualize ODD. This modality has led to a greater ability to differentiate ODD from optic disc edema and prevent misdiagnosis or invasive testing. We review the characteristic findings of ODD on OCT, their distinguishing features, and the use of OCT as a biomarker in the neuro-ophthalmic assessment of ODD. | J.Alexander Fraser Lulu L.C.D.Bursztyn | 2020 | Annals of Eye Science2020，，1： | 0 |
| 15 | A Company Presents Itself to the World显示文摘As we all know,environmental breakdown is rooted in capitalism’s quest for perpetual growth.According to O’Connor(quoted in Büscher et al 2010/2013,p.3)the“environmental crisis has given liberal capitalist society a new lease on life.”He continues:“Now,through purporting to take in hand the saving of the environment,capitalism invents a new legitimation for itself:the sustainable and rational use of nature”.“Those who hold the power and they are not all heads of state,see themselves as saviours of the world,and offer the population the opportunity of becoming their clients”is how John Berger has referred to such cognitive dissonance.Critical discourse analysis and corpus linguistics are employed to scrutinize a powerful corporation’s website.This company produces and distributes food globally.The story it presents to the world maintains that it protects animal welfare,the environment and people,among other things,in all its operations.The language it employs on its corporate websites will be subjected to close analysis. | Richard J.Alexander | 2023 | Journal of Literature and Art Studies2023，13，10： | 0 |
| 16 | Effect of lymphotoxin blockage on different stages of Sjogren's syndrome in an animal model显示文摘Background:Lymphotoxin(LT)is an important mediator in Sjogren's syndrome(SS),both in patients and in animal models.Deletion of the LT alpha gene prevented the development of disease manifestations in the interelukin alpha transgenic mouse(IL14αTG)mouse model of SS.Aims:The current study was designed to evaluate the use of LT inhibitors at different stages of the disease in IL14αTG mice.Materials and Methods:IL14αTG mice were treated with anti‐LTa monoclonal antibody,LTb receptor‐immunoglobulin fusion protein(LTBR‐Ig)or isotype control during different stages of disease and analysis of salivary gland function,immunoglobulins,autoantibodies and histology of internal organs performed.Results and Discussion:The inhibitors were very effective in maintaining salivary gland function and preventing infiltration of the glands with lymphocytes when used in the early stages of the disease.Blocking LT at later stages of the disease did not recover salivary gland function but was still effective in limiting extra glandular manifestations including eye disease and tumor development.Some differences were noted in the effectiveness of anti‐LTαversus LTBR‐Ig in limiting particular disease manifestations.Conclusion:LT inhibitors deserve further investigation in the management of SS at whatever stage is identified. | Alexander Jacob Long Shen Jing He Kelly Nealon Jessy J.Alexander Julian L.Ambrus Jr | 2022 | Rheumatology & Autoimmunity2022，2，2： | 0 |
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