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| 1 | Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure显示文摘BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in D-galactosamine(GalN)sensitized mice.The aim of this study was to identify the role of Ron in the regulation of hepatic gene expression.METHODS:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of ALF.Gene array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture systems.RESULTS:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and metabolism.One hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as JAK-STAT pathway activation were prominent in TK-/livers compared to controls.CONCLUSION:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and JAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF. | Rishikesh M Kulkarni Louis W Kutcher William D Stuart Daniel J Carson Mike A Leonis Susan E Waltz | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，4： | 3 |
| 2 | Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinasdmTOR inhibitor显示文摘 | Van Aller G S Carson J D Tang W | 2011 | Biochem Biophys Res Cornmun2011，406，2： | 1 |
| 3 | A Faraday effect optical isolator显示文摘 | L J Aplet J W Carson | 1964 | Appl Opt1964，3，4： | 1 |
| 4 | 显示文摘 | Jolly M R Bender J W Carson J | 1998 | SPIE1998，3327，： | 1 |
| 5 | Bin loads-Part 2: concepts 显示文摘 | A W Jenike J R Johanson and J W Carson | 1973 | Journal of Engineering for Industry1973，，： | 1 |
| 6 | The Importance of Storage, Transfer and Collection 显示文摘 | KNOWLTON T M CARSON J W KLINZING G E | 1994 | Chemical Engineering Progress1994，90，1： | 1 |
| 7 | The Effects of Positiveand Negative Online Customer Reviews : do Brand Strength andCategory Maturity Matter显示文摘 | Ho-Dac N N Carson S J Moore W L | 2013 | Journal of Marketing2013，77，6： | 1 |
| 8 | Atrial fibrillation in pregnancy associated with oral terbutaline显示文摘 | Carson M P Fisher A J Scorza W E | 2002 | Obstet Gynecol2002，100，5： | 1 |
| 9 | Development of an InternationalStandard for Shear Testing显示文摘 | CARSON J W HARALD W | 2006 | Powder Technology2006，167，： | 1 |
| 10 | Extended Antkumor Response of a BRAF V600E Papillary Thyroid Carcinoma to Vemurafenib显示文摘 | Ali SM He J Carson W | 2014 | Case Rep Oncol2014，7，： | 1 |
| 11 | Arthroscopy of the elbow 显示文摘 | Andrews J R Pierre P K Carson W G | 1986 | Clin Sports Med1986，5，： | 1 |
| 12 | Effect of supplementation with barium selenate on the fertility, prolificacy and lambing performance of hill sheep 显示文摘 | Mufioz C Carson A F McCoy M A Dawson L E Irwin D Gordon A W Kilpatriek D J | 2009 | The Veterniary Record2009，164，9： | 1 |
| 13 | Image-based dendrometry system for standing trees 显示文摘 | Brownlie R K Carson W W Firth J G | 2007 | New Zealand Journal of Forestry Science2007，37，2： | 1 |
| 14 | Genome sequence of Streptococcus mutans UA159,a cariogenic dental pathogen 显示文摘 | Ajdic D McShan W M McLaughlin R E Savie G Chang J Carson M B | 2002 | Proc Natl Aead Sci USA2002，99，14： | 1 |
| 15 | Plasma levels of endothelial cell protein C receptor are elevated in patients with sepsis and systemic lupus erythematosus:lack of correlation with thrombomodulin suggests involvement of different pathological processes显示文摘 | Kurosawa S Stearns-Kurosawa D J Carson C W | 1998 | Blood1998，91，2： | 1 |
| 16 | Fenofibrate represses interleukin-17 and interferon-γ expression and improves colitis in interleukin-10-deficient mice 显示文摘 | Lee J W Bajwa P J Carson M J | 2007 | Gastroenterology2007，133，1： | 1 |
| 17 | Effect of insecticides for control of leafminers on lima beans,1997显示文摘 | CARSON W TRUMBLE J | 1998 | Arthro Management Tests1998，23，1： | 1 |
| 18 | Interleuldn IL - 15 is a novel cytokine that activates human natural killer cells via compo- nents of the IL - 2 receptor显示文摘 | Carson W E Lindemann 1~1 J Linett M L | 1994 | J Exp Ned1994，180，： | 1 |
| 19 | Use of deception to achieve double-blinding in a clinical trial of Melaleuca alternifolia (tea tree) oil for the treatment of recurrent herpes labialis显示文摘 | Carson C F Smith D W Lampacher G J | 2008 | Contemporary Clinical Trials2008，29，1： | 1 |
| 20 | A career entrenchment model: Theoretical development and empirical outcomes 显示文摘 | Carson K D Philips J S Roe C W | 1996 | Journal of Career Development1996，22，4： | 1 |
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