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| 1 | Role of polyethylene particles in peri-prosthetic osteolysis:A review显示文摘There is convincing evidence that particles produced by the wear of joint prostheses are causal in the periprosthetic loss of bone,or osteolysis,which,if it progresses,leads to the phenomenon of aseptic loosening.It is important to fully understand the biology of this bone loss because it threatens prosthesis survival,and loosened implants can result in peri-prosthetic fracture,which is disastrous for the patient and presents a difficult surgical scenario.The focus of this review is the bioactivity of polyethylene(PE)particles,since there is evidence that these are major players in the development and progression of osteolysis around prostheses which use PE as the bearing surface.The review describes the biological consequences of interaction of PE particles with macrophages,osteoclasts and cells of the osteoblast lineage,including osteocytes.It explores the possible cellular mechanisms of action of PE and seeks to use the findings to date to propose potential nonsurgical treatments for osteolysis.In particular,a nonsurgical approach is likely to be applicable to implants containing newer,highly cross-linked PEs(HXLPEs),for which osteolysis seems to occur with much reduced PE wear compared with conventional PEs.The caveat here is that we know little as yet about the bioactivity of HXLPE particles and addressing this constitutes our next challenge. | Gerald J Atkins David R Haynes Donald W Howie David M Findlay | 2011 | World Journal of Orthopedics2011，2，10： | 11 |
| 2 | Edge termination for very high voltage IGBT devices显示文摘 | Coulbeck L | 1997 | IPEMC''971997，1，： | 1 |
| 3 | Bacterial production in fresh and saltwater ecosystems : a cross - system overview显示文摘 | Cole J J Findlay S Pace M L | 1988 | Mar Ecol Prog Set1988，43，： | 1 |
| 4 | Experience with computed tomogaphic angiography for the detection of intracranial aneurysms in the setting of acute subarachnoid hemorrhage显示文摘 | Anderson G B Findlay J M Steinke D E | 1997 | Neurosurgery1997，41，3： | 1 |
| 5 | Bioactive compounds from needles显示文摘 | Findlay J A Li G Johnson J A | 1997 | CanJ Chem1997，75，： | 1 |
| 6 | Newly identified endometrial genes of importance for implantation显示文摘 | Salamonsen L A Nie G Findlay J K | 2002 | J Reprod Immunol2002，53，12： | 1 |
| 7 | Activin A and inhibin A differentially regulate human uterine matrix metalloproteinases: potential interactions during decidualization and trophoblast in- vasion显示文摘 | Jones R L Findlay J K Farnworth P G | 2006 | Endocrinology2006，147，2： | 1 |
| 8 | The road to ovulation:the role of oestrogens显示文摘 | Findlay J K Britt K Kerr J B | 2001 | Reprod Fertil Dev2001，13，： | 1 |
| 9 | Currents of the mechanisms of menstruation 显示文摘 | Salamonsen L A Kovacs G T Findlay J K | 1999 | Baillieres Best Pract Res Clin Obstet Gynaecol1999，13，2： | 1 |
| 10 | Average volumetric concentration in two-phase flow systems显示文摘 | Zuber N Findlay J A | 1965 | Trans of the ASME1965，87，： | 1 |
| 11 | Biophysical controls on organic carbon fluxes in fluvial networks显示文摘 | BATTIN T J KAPLAN L A FINDLAY S | 2008 | Nature Geoscience2008，1，2： | 1 |
| 12 | Average volumetric concentration in tow-phase flow systems显示文摘 | Zuber N Findlay J | 1965 | Journal of Heat Transfer1965，85，1： | 1 |
| 13 | Biofilm dispersal in Xanthomonas campestris is controlled by cell-cell signaling and is required for full virulence to plant 显示文摘 | DOW M J CROSSMAN L FINDLAY K | 2003 | Proceedings of the Na-tional Academy of Sciences of the United States of America2003，100，10： | 1 |
| 14 | Familial adrenocorticotropin-independent Cushing's syndrome with bilateral macronodular adrenal hyperplasia显示文摘 | Findlay J C Sheeler L R Engeland W C | 1993 | J Clin Endocrinol Metab1993，76，： | 1 |
| 15 | The interaction of retinol - binding protein with its plasma - membrane receptor显示文摘 | Sivaprasadarao A Findlay J B | 1988 | Biochem1988，255，： | 1 |
| 16 | Effect of invasive plant species on temperate wetland plant diversity显示文摘 | Houlahan J E Findlay C S | 2004 | Conservation Biolo- gy2004，18，4： | 1 |
| 17 | Thermomechanical properties of beef muscle 显示文摘 | C J Findlay D W Stanley E A Gullett | 1986 | Meat Science1986，16，： | 1 |
| 18 | Clinical,heamodynamic,and antiarrhythmic effects of long term treatment with amiodarone of patients in heart failure显示文摘 | DARGIE H J FINDLAY I N | 1987 | Br Heart J1987，57，4： | 1 |
| 19 | Current concepts of pathophysioloay and management of cerebral vasospasm fol- lowing aneurismal subarachnoid hemorrgage显示文摘 | Findlay J M Macdonald R L Weir B K A | 1991 | Cerebrovase Brain Metab Res1991，3，： | 1 |
| 20 | Influence of sodium, potassium and magnesium chloride on thermal properties of beef muscle显示文摘 | BARBUT S FINDLAY J C | 1991 | Journal of Food Science1991，56，1： | 1 |
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