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您的检索式：作者名="Gerald J Atkins"
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| 1 | Role of polyethylene particles in peri-prosthetic osteolysis:A review显示文摘There is convincing evidence that particles produced by the wear of joint prostheses are causal in the periprosthetic loss of bone,or osteolysis,which,if it progresses,leads to the phenomenon of aseptic loosening.It is important to fully understand the biology of this bone loss because it threatens prosthesis survival,and loosened implants can result in peri-prosthetic fracture,which is disastrous for the patient and presents a difficult surgical scenario.The focus of this review is the bioactivity of polyethylene(PE)particles,since there is evidence that these are major players in the development and progression of osteolysis around prostheses which use PE as the bearing surface.The review describes the biological consequences of interaction of PE particles with macrophages,osteoclasts and cells of the osteoblast lineage,including osteocytes.It explores the possible cellular mechanisms of action of PE and seeks to use the findings to date to propose potential nonsurgical treatments for osteolysis.In particular,a nonsurgical approach is likely to be applicable to implants containing newer,highly cross-linked PEs(HXLPEs),for which osteolysis seems to occur with much reduced PE wear compared with conventional PEs.The caveat here is that we know little as yet about the bioactivity of HXLPE particles and addressing this constitutes our next challenge. | Gerald J Atkins David R Haynes Donald W Howie David M Findlay | 2011 | World Journal of Orthopedics2011，2，10： | 11 |
| 2 | The proliferation and phenotypic expression of human osteoblasts on tantalum metal显示文摘 | David M Findlay Katie Welldon Gerald J Atkins Donald W Howie Andrew C.W Zannettino Dennis Bobyn | 2003 | Biomaterials2003，，12： | 1 |
| 3 | Sclerostin is a locally acting regulator of late‐osteoblast/preosteocyte differentiation and regulates mineralization through a MEPE‐ASARM‐dependent mechanism显示文摘 | Gerald J Atkins Peter S Rowe Hui P Lim Katie J Welldon Renee Ormsby Asiri R Wijenayaka Lesya Zelenchuk Andreas Evdokiou David M Findlay | 2011 | J Bone Miner Res2011，，7： | 1 |
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