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| 1 | Traditional fertilizion and its effect on corn insect populations in the Guatemalan highlands显示文摘 | Helda M Ivette P Bruce F | 2001 | Agriculture Ecosystems & Environment2001，84，： | 1 |
| 2 | HCV-specific immune responses induced by CIGB-230 in combination with IFN-α plus ribavirin显示文摘AIM:To analyze hepatitis C virus(HCV)-specific immune responses in chronically infected patients under triple therapy with interferon-α(IFN-α)plus ribavirin and CIGB-230.METHODS:CIGB-230 was administered in different schedules with respect to IFN-αplus ribavirin therapy.Paired serum and peripheral blood mononuclear cells(PBMC)samples from baseline and end of treatment were analyzed.The HCV-specific humoral response was tested by enzyme-linked immunosorbent assay,neutralizing antibodies were evaluated by cell culture HCV neutralization assays,PBMC proliferation was assayed by carboxyfluorescein succinimidyl ester staining and IFN-γsecretion was assessed by enzyme-linked immunospot.Data on virological and histological response and their association with immune variables are also provided.RESULTS:From week 12 to week 48,all groups of patients showed a significant reduction in mean leukocyte counts.Statistically significant reductions in antibody titers were frequent,but only individuals immunized with CIGB-230 as early add-on treatment sustained the core-IgG response,and the neutralizing antibody response was enhanced only in patients receiving CIGB-230.Cell-mediated immune responses also tended to decline,but significant reductions in IFN-γsecretion and total absence of core-specific lymphoproliferation were exclusive of the control group.Only CIGB-230-immunized individuals showed de novo induced lymphoproliferative responses against the structural antigens.Importantly,it was demonstrated that thequality of the CIGB-230-induced immune response depended on the number of doses and timing of administration in relation to the antiviral therapy.Specifically,the administration of 6 doses of CIGB-230 as late addon to therapy increased the neutralizing antibody activity and the de novo core-specific IFN-γsecretion,both of which were associated with the sustained virological response.CONCLUSION:CIGB-230,combined with IFN-α-based therapy,modifies the immune response in chronic patients.The study provides evidence for the design of more effective therapeutic vaccine interventions against HCV. | Yalena Amador-Caizares Gillian Martínez-Donato Liz lvarez-Lajonchere Claudia Vasallo Mariacarla Dausá Daylen Aguilar-Noriega Carmen Valenzuela Ivette Raíces Jean Dubuisson Czeslaw Wychowski Zurina Cinza-Estévez Marlén Castellanos Magdalys Núez Anny Armas Yaimé González Ismariley Revé Ivis Guerra ngel Pérez Aguiar Santiago Dueas-Carrera | 2014 | World Journal of Gastroenterology2014，20，1： | 1 |
| 3 | Supercritical water oxidation of phenol and 2,4-dinitrophenol显示文摘 | IVETTE V P STEVEN R RICHARD B | 2004 | J of Supercritical Fluids2004，30，： | 1 |
| 4 | A dynamic Bayesian network for estimating the risk of falls from real gait data显示文摘 | German Cuaya Angélica Mu?oz-Meléndez Lidia Nu?ez Carrera Eduardo F. Morales Ivett Qui?ones Alberto I. Pérez Aldo Alessi | 2013 | Medical & Biological Engineering & Computing2013，，1： | 1 |
| 5 | Erratum to:Aqueous extracts from Tenebrio molitor larval and pupal stages inhibit early hepatocarcinogenesis in vivo显示文摘Following an Assessment by the Autonomous University of Hidalgo State and the National Institute of Genomic Medicine,this erratum corrects the authorship of this article by adding Dulce Maria MORENO-GARCiA as the first author.The published article(Zepeda-Bastida et al.,2021)has now been updated with the corrected authorship,author contributions,and acknowledgments,which may be seen in this erratum. | Dulce María Moreno-García Armando Zepeda-Bastida Juan Ocampo-López Brisa Rodope Alarcón-Sánchez Osiris Germán Idelfonso-García Sandra Rosas-Madrigal Diana Ivette Aparicio-Bautista Julio Isael Pérez-Carreón Saúl Villa-Treviño Jaime Arellanes-Robledo | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，4： | 0 |
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