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| 1 | 常规排泄式膀胱尿道造影术对新生儿单侧多囊性肾发育不良无诊断意义显示文摘Objectives: To determine if two successive ultrasound examinations could rule out the presence of clinically significant contralateral anomalies in neonates with multicystic dysplastic kidney (MCDK), thereby avoiding unnecessary voiding cystourethrography (VCUG). Study design: We followed 76 newborn infants with antenatally discovered MCDK. Two successive neonatal renal ultrasound examinations were performed, one within the first week and one at around 1 month of life. VCUG and isotopic studies were performed in all infants. Results: Urologic anomalies of the contralateral kidney were present in 19 of 76 children (25% ): vesicoureteral reflux (VUR) in 16 (21% ), ureteropelvic junction obstruction in 2 (3% ), and renal duplex kidney in 1 (1% ). Sixty-one infants (80% of total) had normal contralateral urinary tract on the 2 successive neonatal renal ultrasound scans. Among them, 4 of 61 (7% ) infants presented with low-grade VUR on VCUG that had resolved spontaneously before 2 years of age. The sensitivity, specificity, positive predictive value, and negative predictive value of two successive ultrasound scans in the neonatal period to predict contralateral urological anomalies on VCUG were 75% , 95% , 80% , and 93% , respectively. Conclusions: In infants with antenatally diagnosed MCDK, two successive normal neonatal renal ultrasound scans will rule out clinically significant contralateral anomalies, thereby rendering the need for a neonatal VCUG unnecessary. | Ismaili K. Avni F.E. Alexander M. 郭战宏 | 2006 | 世界核心医学期刊文摘(儿科学分册)2006，2，2： | 1 |
| 2 | 在有胎儿期肾盂扩张史的新生儿中所检测到的原发性膀胱输尿管反流:一项前瞻性临床和影像学研究显示文摘Objective:To assess the clinical outcome and imaging features of neonatal pri mary vesicoureteral reflux(VUR).Study design:We prospectively followed 43 inf ants with primary VUR identified from among a cohort of 497 infants with fetal r enal pelvis dilatation.Postnatal renal ultrasound(US)examinations were perfor med at 5 days and 1,3,6,12,and 24 months of life.Voiding cystourethrography was performed in the neonatal period and repeated at 12 and 24 months when VUR was persistent.Two radioisotopic examinations,including a 99mTc-MAG3 renogram and a plasma clearance of Cr-51 EDTA,were performed in all children with high-grade reflux.Results:The incidence of primary VUR in our study group was 9%.Among the 43 patients followed,11(26%)had high-grade(IV-V)VUR and 32(74%)had low-grade VUR.Resolution of reflux occurred in 2 of 11(18%)patien ts with high-grade VUR and in 29 of 32(90.6%)patients with low-grade VUR at age 2 years(P < 0.001).At age 2 years,91%of the low-grade refluxing kidne ys were normal on US,compared with only 35%of the high-grade refluxing kidney s.Split renal function was within normal range and single-kidney GFR was signi ficantly increased in 13 of the 17 high-grade refluxing kidneys during follow-up.Furthermore,a strong association between dysplasia on US and poor renal fun ction outcome was found.Conclusions:In most infants with VUR,the reflux is of low grade and resolves rapidly.In those children with high-grade VUR,spontan eous resolution is rare at age 2 years,but persistent reflux rarely impairs the maturation of renal function. | Ismaili K. Hall M. Piepsz A. 王一飞 | 2006 | 世界核心医学期刊文摘(儿科学分册)2006，2，8： | 0 |
| 3 | 胎儿期有轻、中度肾盂扩张婴儿的远期临床结果:新生儿明显泌尿系统疾病的超声筛查 | Ismaili K. Avni F. E. Wissing K. M. Hall M. 贺莉 | 2005 | 世界核心医学期刊文摘(儿科学分册)2005，0，4： | 0 |
| 4 | 单侧复杂性双肾畸形儿童单个肾的功能改变显示文摘Objective: To assess the evolution of individual renal function during the mat uration process in terms of single kidney glomerular filtration rate (SKGFR) and split function in children with unilateral complex renal duplication. Study des ign: We retrospectively reviewed the records of 44 children with unilateral comp lex duplex kidney. All affected kidneys had a poor or nonfunctioning dysplastic moiety, 28 in the upper pole and 16 in the lower pole. At least 2 radioisotopic examinations, including a 99mTc-mercaptoacetyltriglycine (99mTc-MAG3) renogram and a plasma clearance of 51Cr-ethylenediaminetetraacetic acid (Cr-51 EDTA), were performed in all children, the first one performed at a median age of 3 mon ths (range 2 to 15 months) and the last one at 24 months (range 12 to 120 months ). They allowed a precise estimation of split renal function, overall glomerular filtration rate (GFR), and SKGFR. Results: Mean overall kidney GFR increased si gnificantly between the two measurements from 63 ±12.7 mL/minute/1.73m2 to 95 ±21 mL/minute/1.73m 2 (P < .0001). SKGFR of the duplex side similarly increased from 26 ±7.7 mL/minute/1.73m2 to 38 ±12.6 mL/minute/1.73m2 (P < .0001). In te rms of split function, the affected kidney had a remarkable stable function betw een the two measurements, 40%±8.6 and 39%±8.3 (P = .94), respectively. Howev er, cases with the lowest initial split function ( < 30%) had the lowest initia l SKGFR and the worst further evolution. Conclusion: In children with unilateral complex renal duplication, we found on the affected side a significant increase of SKGFR because of renal maturation, whereas mean split function remained stab le during follow-up. | Ismaili K. Hall M. Ham H. Piepsz A. 王一飞 | 2006 | 世界核心医学期刊文摘(儿科学分册)2006，0，1： | 0 |
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