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| 1 | Efficacy and safety of tenofovir in chronic hepatitis B: Australian real world experience显示文摘AIM To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting.METHODS We performed a retrospective analysis of treatment outcomes among treatment-na?ve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate(TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent. Patients were excluded if they demonstrated human immune-deficiency virus/hepatitis C virus/hepatitis delta virus coinfection or were less than 18 years of age. We considered virological and biochemicalresponse, as well as safety outcomes. Virological response was determined by measurement of hepatitis B virus(HBV) DNA using sensitive assays; biochemical response was determined via serum liver function tests; histological response was determined from liver biopsy and fibroscan; safety analysis focused on glomerular renal function and bone mineral density. The primary efficacy endpoint was complete virological suppression over time, defined by HBV DNA < 20 IU/m L. Secondary efficacy endpoints included rates of biochemical response, and HB e antigen(HBe Ag)/HB surface antigen loss and seroconversion over time.RESULTS Ninety-two patients were identified who fulfilled the enrolment criteria. Median follow-up was 26 mo(range 3-114). Mean age was 46(24-78) years, 64(70%) were male and 77(84%) were of Asian origin. 55(60%) patients were treatment-na?ve and 62 patients(67%) were HBe Ag-negative. Complete virological suppression was achieved by 45/65(71%) patients at 12 mo, 37/46(80%) at 24 mo and 25/28(89%) at 36 mo. Partial virological response(HBV DNA 20-2000 IU/m L) was achieved by 89/92(96.7%) of patients. Multivariate analysis showed a significant relationship between virological suppression at end of follow-up and baseline HBV DNA level(OR = 0.897, 95%CI: 0.833-0.967, P = 0.0046) and HBe Ag positive status(OR = 0.373, 95%CI: 0.183-0.762, P = 0.0069). There was no difference in response comparing treatment-na?ve and treatment-experienced patients. Three episodes of virological breakthrough occurred in the setting of noncompliance. Tenofovir therapy was well tolerated.CONCLUSION Tenofovir is an efficacious, safe and well-tolerated treatment in an Australian real-world tertiary care setting. Our data are similar to the reported experience from registration trials. | Grace C Lovett Tin Nguyen David M Iser Jacinta A Holmes Robert Chen Barbara Demediuk Gideon Shaw Sally J Bell Paul V Desmond Alexander J Thompson | 2017 | World Journal of Hepatology2017，9，1： | 7 |
| 2 | IL 28 B genotype is not useful for predicting treatment outcome in A sian chronic hepatitis B patients treated with pegylated interferon‐α显示文摘 | Jacinta A Holmes Tin Nguyen Dilip Ratnam Neel M Heerasing Jane V Tehan Sara Bonanzinga Anouk Dev Sally Bell Stephen Pianko Robert Chen Kumar Visvanathan Rachel Hammond David Iser Ferry Rusli William Sievert Paul V Desmond D Scott Bowden Alexander J Thomps | 2013 | J Gastroenterol Hepatol2013，，5： | 2 |
| 3 | The child's experience of ADHD显示文摘 | Sciberras E Efron D Iser A | 2011 | J At-ten Disord2011，15，4： | 1 |
| 4 | Reliability and Validity of the Functional Analysis Screening Tool 显示文摘 | lwata Brian A Deleon Iser G Roscoe Eileen M | 2013 | Journal of Applied Behavior Analysis2013，，46： | 1 |
| 5 | Uncoupling protein homologs may provide a link between mitochondria, metabolism and lifespan显示文摘 | Wolkow C A Iser W B | 2006 | Ageing Res Rev2006，5，： | 1 |
| 6 | Serum hepatitis B surface anti- gen and hepatitis B e antigen titers:disease phase influences correlation with viral load and intrahepatic 显示文摘 | Thompson A J Nguyen T Iser D | 2010 | Hepatology2010，51，6： | 1 |
| 7 | Serum hepatitis B surface B antigen and hepatitis Be antigen titers:disease phase influences correlation with viral load and intrahepatic hepatitis B virus marker 显示文摘 | Thompson A J Nguyen T Iser D | 2010 | Hepatology2010，51，6： | 1 |
| 8 | Serum hepatitis B surface antigen and hepatitis B e antigen titers: disease phase influences correlation with viral load and intrahe- patic hepatitis B virus markers 显示文摘 | Thompson A J Nguyen T Iser D | 2010 | Hepatology2010，51，6： | 1 |
| 9 | Serum hepatitis B surface antigen and hepatitis B e antigen titers: disease phase in- fluences correlation with viral load and intrahepatic hepatitis B vi- res makers显示文摘 | THOMPSON A J NGUYEN T ISER D | 2010 | Hepatology2010，51，6： | 1 |
| 10 | Results of intracoronary recombinant human vascular growth factor(rhVEGF) administration trial显示文摘 | Henry T D Rocha-Singh K Iser J M a al | 1998 | J Am Coll Cardiol1998，31，： | 1 |
| 11 | Serum hepatitis B surface antigen and hepatitis B e antigen titers:disease phase influences correlation with viral load and intrahepatic hepatitis B virus markers显示文摘 | Thompson AJ Nguyen T Iser D Ayres A Jackson K Littlejohn M Slavin J Bowden S Gane EJ Abbott W | | 0，，06： | 1 |
| 12 | Serum hepatitis B surface antigen and hepatitis B e antigen titers: disease phase influences correlation with viral load and intrahepatic hepatitis B virus markers显示文摘 | Thompson A J Nguyen T Iser D | 2010 | Hepatology2010，51，6： | 1 |
| 13 | Stable transformation of sunflower using a non - meristematic regeneration protocol and green fluorescent protein as a vital marker 显示文摘 | Muller A Iser M Hess D | 2001 | Transgenic Res2001，10，5： | 1 |
| 14 | Serum hepatitis B surface antigen and hepatitis B e antigen titers: disease phase influences correlation with viral load and intrahepatic hepatitis virus markers显示文摘 | Thompson A J Nguyen T Iser D | 2010 | Hepatology2010，51，6： | 1 |
| 15 | Porcine T lympho- eytes and NK cells An update显示文摘 | Gerner W K/iser T Saalmiiller A | 2009 | Developmental and Comparative Immunology2009，33，： | 1 |
| 16 | Serum hepati-tis B surface antigen and hepatitis B e antigen titers ; dis-ease phase influences correlation with viral load and in-trahepatic hepatitis B virus markers 显示文摘 | Thompson A J Nguyen T Iser D | 2010 | Hepatol2010，51，6： | 1 |
| 17 | Stable transformation of sunflower using a non-meristematic regeneration protocol and green fluorescent protein as a vital marker显示文摘 | Muller A Iser M Hess D | 2001 | Transgenic Res2001，10，5： | 1 |
| 18 | Serum hepatitis B surface antigen and hepatitis B e antigen titers : disease phaseinfluences correlation with viral load and intrahepatic hepatitis B virus markers显示文摘 | THOMPSON A J NGUYEN T ISER D | 2010 | Hepatology2010，51，6： | 1 |
| 19 | The Local Perturbation Method for Solving the Problem of Diffraction from a Surface with Small Slope Irregularities 显示文摘 | Isers A B Puzenko A A Fuks I M | 1991 | J Electromagn Wave Appl1991，，5： | 1 |
| 20 | Serum hepatitis B surface an- tigen and hepatitis B e antigen titers:disease phase influences corre- lation with viral load and intrahepatic hepatitis B virus markers显示文摘 | Thompson A J Nguyen T Iser D | 2010 | Hepatology2010，51，6： | 1 |
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