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您的检索式：作者名="Isamu MAEBA"
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| 1 | Identification of some benproperine metabolites in humans and investigation of their antitussive effect显示文摘瞄准:识别 benproperine 的 4 未知代谢物,并且调查 monohydroxylate 代谢物的能止咳的效果(BPP, 1 ) 在在 po 剂量以后的人的尿。方法:通常认为的代谢物参考书用化学合成被准备。他们的结构用 1H 和 13C 被识别原子磁性的回声,和集体分光术。在人的尿的代谢物被分开,用液体层析离子的 assayed 套住集体分光术(LC/MS/MS ) ,并且推进综合参考物质与那些由他们的集体系列和色析法的保留时间的比较证实了。代谢物的能止咳的效果在 7.5% 枸橼酸在有意识的畿尼猪导致的咳嗽上被评估。结果:1-[1-Methyl-2-[2-( 苯基甲基) 含苯氧基]-ethyl]-4-piperidinol (2 ) , 1-[1-methyl-2-[2-( 苯基甲基) 含苯氧基] 乙醇]-3-piperidinol (3 ) 和他们的 glucuronides 4 和 5 从化学合成被获得。在人的尿的四尿代谢物在 LC/MS/MS 同样合成的物质与一样的色析法的保留时间和集体系列显示出山峰 2, 3, 4 和 5。混合物的磷酸盐 2 和 3 延长了咳嗽的潜伏并且在 3 min 期间减少了咳嗽的数字测试使用枸橼酸,但是没在有意识的畿尼猪的测试以后立即在 5 min 期间减少咳嗽的数字。结论:混合物 2, 3, 4,和 5 在人的尿作为 BPP 的代谢物被识别。在他们之中,加重 2 和 3 在能止咳的效果是不活跃的。 | Yan LI Da-fang ZHONG Si-wei CHEN Isamu MAEBA | 2005 | Acta Pharmacologica Sinica2005，26，12： | 4 |
| 2 | Synthesis of pyrrolo[2,1- f ][1,2,4]triazine C -nucleosides. Isosteres of sangivamycin, tubercidin, and toyocamycin显示文摘 | Natsu Nishimura Ai Kato Isamu Maeba | | Carbohydrate Research0，，： | 1 |
| 3 | Glucuronidation of Two Novel Metabolites of Benproperine with Trichloroacetimidate Donor显示文摘The glucuronide metabolites of benproperine were synthesized from mono-hydroxylate metabolites of benproperine that were treated with methyl(2,3,4-tri-O-acetyl-1-O-trichloroacetimidoyl)-α-D-glucopyranuronate with BF_ 3 ·Et_ 2 O as the promoter followed by basic hydrolyzation with Na_ 2 CO_ 3 . The form of basic acceptors, the order of addition, and the promoter are all important variables in this glucuronidation. The salt form of the basic acceptor was found to be better than its free form for glucuronidation with a Lewis acid as the promoter. Two mono-hydroxylated benproperines were synthesized from 2-benzylphenol in three steps. | LI Yan HARA Osamu MAEBA Isamu ZHONG Da-fang | 2006 | Chemical Research in Chinese Universities2006，22，4： | 0 |
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