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| 1 | Clinical-pathological and molecular characterization of long-term survivors with advanced non-small cell lung cancer显示文摘Objective:Long-term survivors(LS)of non-small cell lung cancer(NSCLC)without driver alterations,displaying an overall survival(OS)of more than 3 years,comprise around 10%of cases in several series treated with chemotherapy.There are classical prognosis factors for these cases[stage,Eastern Cooperative Oncology Group(ECOG),etc.],but more data are required in the literature.In this multi-center study,we focused on LS of advanced NSCLC with OS above 36 months to perform a clinical-pathological and molecular characterization.Methods:In the first step,we conducted a clinical-pathological characterization of the patients.Afterwards,we carried out a genetic analysis by comparing LS to a sample of short-term survivors(SS)(with an OS less than 9 months).We initially used whole-genome RNA-seq to identify differentiating profiles of LS and SS,and later confirmed these with reverse transcription-polymerase chain reaction(RT-PCR)for the rest of the samples.Results:A total of 94 patients were included,who were mainly men,former smokers,having adenocarcinoma(AC)-type NSCLC with an ECOG of 0-1.We obtained an initial differential transcriptome expression,displaying 5 over-and 33 under-expressed genes involved in different pathways:namely,the secretin receptor,surfactant protein,trefoil factor 1(T FF1),serpin,Ca-channels,and Tolllike receptor(TLRs)families.Finally,RT-PCR analysis of 40(20 LS/20 SS)samples confirmed that four genes(surfactant proteins and SFTP)were significantly down-regulated in SS compared to LS by using an analysis of covariance(ANCOVA)model:SFTPA1(P=0.023),SFTPA2(P=0.027),SFTPB{P=0.02),and SFT PC(P=0.047).Conclusions:We present a sequential genetic analysis of a sample of NSCLCLS with no driver alterations,obtaining a differential RNA-seq/RT-PCR profile showing an abnormal expression of SF genes. | Juan Moreno-Rubio Santiago Ponce Rosa Alvarez Maria Eugenia Olmedo Sandra Falagan Xabier Mielgo Fatima Navarro Patricia Cruz Luis Cabezon-Gutierrez Carlos Aguado Gonzalo Colmenarejo Marta Munoz-Fernandez de Leglaria Ana Belen Enguita Maria Cebollero Amparo Benito Isabel Alemany Carolina del Castillo Ricardo Ramos Ana Ramirez de Molina Enrique Casado Maria Sereno | 2020 | Cancer Biology & Medicine2020，17，2： | 4 |
| 2 | Nuptial gifts and female fecundity in the neotropical katydid Conocephalus ictus (Orthoptera: Tettigonidae)显示文摘一般来说,女健康极大地在给礼品的昆虫被增加。在纺织娘,这件结婚礼品由附件腺生产的一个凝胶状的团组成:spermatophylax,它被纳入两耳细颈瓶。在交配期间,新热带区的纺织娘 Conocephalus 冲击的男性转移被女性摄取的 spermatophylax。肥沃,生蛋的率和长寿在比在那些消费了 spermatophylax 的女性是更高的。另外,女感受性在交配以后关掉。女性们活跃地由用他们的前肢撞击他们并且离开移动拒绝了另外的男性。他们的倔强的时期持续了只要 17d。仅仅一些女性接受了第二交配并且一些天以后死了。在 C。冲击, spermatophylax 消费能为男性和女性是有益的。一方面,在 spermatophylax 的混合物或精液能阻止或推迟女性与对手交接,因此避免精子竞争。在另一方面,如此的混合物能改进 females’机会将增加他们的 lifespan 和肥沃。而且,处于生蛋的率的上升可以降低快速的 oviposition 引起的女 prereproductive 死亡的风险。在任何情况下,因为他们后代的数字增加,在生的女鸡蛋的增加可能也为男性是有益的。 | Isabel Ortiz-Jimenez Raul Cueva del Castillo | 2015 | Insect Science2015，22，1： | 2 |
| 3 | Autocrine production of TGF-β confers resistance to apoptosis after an epithelial–mesenchymal transition process in hepatocytes: Role of EGF receptor ligands显示文摘 | Gaelle del Castillo Miguel M. Murillo Alberto álvarez-Barrientos Esther Bertran Margarita Fernández Aránzazu Sánchez Isabel Fabregat | 2006 | Experimental Cell Research2006，，15： | 1 |
| 4 | Optimization of the Production of Biogas in Anaerobic Digestion by the Addition of Hydrolytic Microorganisms显示文摘It is well known that fossil fuels are one of the major pollutants that contribute to climate change and there is a need to develop alternatives to their uses.One option is the use of a renewable fuel such as biogas obtained from the breaking down of organic matter in the anaerobic digestion process.When biogas is cleaned up to a certain quality,it can substitute the use of natural gas.However,this slow process requires optimization to increase the amount of gas.There are chemical,physical and biological treatments for organic matter to increase the amount and quality of biogas.In the former research,a biological treatment was tested by adding a selection of microorganisms that showed hydrolytic activity to an anaerobic digester for its optimization.First,a selection of microorganisms with the ability to grow in fresh sewage sludge as only nutrient was selected.Then,the lipolytic,cellulolytic and PA(Proteolytic Activity)of microorganisms was tested using selective growth media.Finally,10 samples with the greatest hydrolytic activity were used to evaluate their effects in the increasing of biogas production in the anaerobic process.The results showed that 83%of the microorganisms with the ability to grow in sewage sludge were proteolytic,while the percentage of lipolytic and cellulolytic microorganisms was smaller.Furthermore,it was found that proteolytic microorganisms are the ones that increase biogas yield in a maximum of 80%with a COD(Chemical Oxygen Demand)reduction of 58%. | María Montes Melissa Cervantes Alejandra Vásquez Víctor Aguilar Pedro García Isabel Del Castillo | 2022 | Journal of Environmental Science and Engineering(A)2022，11，1： | 0 |
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