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| 1 | Out of southern East Asia: the natural history of domestic dogs across the world显示文摘 | Guo-Dong Wang Weiwei Zhai He-Chuan Yang Lu Wang LioZhong Yan-Hu Liu Ruo-Xi Fan Ting-Ting Yin Chun-Ling Zhu Andrei D Poyarkov David M Irwin Marjo K Hytonen Hannes Lohi Chung-I Wu Peter Savolainen Ya-Ping Zhang | 2016 | Cell Research2016，26，1： | 16 |
| 2 | 功能的限制的积极选择而非松驰在鸡驯服期间驾驶视觉的进化显示文摘是由达尔文,注意了鸡有所有鸟,而是国内鸡和他们的野祖先之间的有趣的进化差别的最大的 phenotypic 差异,红 Junglefowl,是他们的比较地更弱的视觉。存在理论建议在国内鸡之中的减少的视觉英勇反映功能的限制的松驰在识别负责的内在的基因机制的视觉,而是证据上驾驶的变化因为这个变化决定性地没被描绘。这里,国内鸡的染色体宽的分析和红 Junglefowl 染色体为涉及视觉的发展的断然选择的基因显示出重要丰富。关于为在视网膜的这些基因的 mRNA 表示的水平国内鸡和他们的野祖先之间有重要差别。涉及视觉的发展的众多的另外的基因也在在国内鸡和他们的野祖先之间的 mRNA 表示显示出重要差别,特别地为与 phototransduction 和光敏电阻器开发联系的基因,例如 RHO (视紫红质) , GUCA1A, PDE6B 和 NR2E3。最后,我们在视觉描绘了 VIT 基因的潜在的角色,它在村庄鸡的视网膜经历了积极选择和 downregulated 表示。总的来说,我们的结果建议净化选择的那种积极选择,而非松驰,在国内鸡贡献了视觉的进化。怀有更弱的视觉的国内鸡的祖先可能显示出减少的害怕回答和警戒,使他们更安逸无意识地被选择或驯养。 | Ming-Shan Wang Rong-wei Zhang Ling-Yan Su Yah Li Min-Sheng Peng He-Qun Liu Lin Zeng David M Irwin Jiu-Lin Du Yong-Gang Yao Dong-Dong Wu Ya-Ping Zhang | 2016 | Cell Research2016，26，5： | 15 |
| 3 | Convergent genomic signatures of high-altitude adaptation among domestic mammals显示文摘Abundant and diverse domestic mammals living on the Tibetan Plateau provide useful materials for investigating adaptive evolution and genetic convergence.Here,we used 327 genomes from horses,sheep,goats,cattle,pigs and dogs living at both high and low altitudes,including 73 genomes generated for this study,to disentangle the genetic mechanisms underlying local adaptation of domestic mammals.Although molecular convergence is comparatively rare at the DNA sequence level,we found convergent signature of positive selection at the gene level,particularly the EPAS1 gene in these Tibetan domestic mammals.We also reported a potential function in response to hypoxia for the gene C10 orf67,which underwent positive selection in three of the domestic mammals.Our data provide an insight into adaptive evolution of high-altitude domestic mammals,and should facilitate the search for additional novel genes involved in the hypoxia response pathway. | Dong-Dong Wu Cui-Ping Yang Ming-Shan Wang Kun-Zhe Dong Da-Wei Yan Zi-Qian Hao Song-Qing Fan Shu-Zhou Chu Qiu-Shuo Shen Li-Ping Jiang Yan Li Lin Zeng He-Qun Liu Hai-Bing Xie Yun-Fei Ma Xiao-Yan Kong Shu-Li Yang Xin-Xing Dong Ali Esmailizadeh David M Irwin Xiao Xiao Ming Li Yang Dong Wen Wang Peng Shi Hai-Peng Li Yue-Hui Ma Xiao Gou Yong-Bin Chen Ya-Ping Zhang | 2020 | National Science Review2020，7，6： | 7 |
| 4 | Effects of sleep and sleep loss on immunity and cytokines显示文摘 | Irwin M | 2002 | Brain Behavior and Immunity2002，16，： | 1 |
| 5 | Patient-maintained propofol sedation:Assessment of a target-controlled infusion system显示文摘 | IRWIN M G THOMPSON N KENNY G N | 1997 | Anaesthesia1997，52，6： | 1 |
| 6 | Fatigue crack growth in pavements显示文摘 | CASTELL M A INGRAFFEA A R IRWIN L H | 2000 | Journal of Transportation Engineering ASCE2000，126，4： | 1 |
| 7 | Evolution of the cytochrome b gene of mammals显示文摘 | Irwin D M Kocher T D Wilson A C | 1991 | J Molecular Evolution1991，2，： | 1 |
| 8 | Biochemical characterisation of the recombinant peroxiredoxin(FhePrx)of the liver fluke,Fasciola hepatica显示文摘 | Sekiya M Mulcahy G Irwin JA | 2006 | FEBS Lett2006，580，21： | 1 |
| 9 | Diphenylhydantoin induced apoptotic cell death of cultured rat cerebellar granule neurons显示文摘 | Irwin RP Lin SZ Weller M Wood KA Paul SM | 1995 | J Pharmacol Exp Ther1995，274，6： | 1 |
| 10 | Ancient duplications of the human proglucagon gene显示文摘 | Irwin D M | 2002 | Genomics2002，79，： | 1 |
| 11 | Tissue expression and immuneolocation of tumor necrosis factor-alpha in post-infartion dysfunctional myocardiam显示文摘 | IRWIN M V MAKS MANN D L | 1999 | Circulation1999，99，： | 1 |
| 12 | Activity studies of eight purified cellulases:specificity,synergism and binding domain effects显示文摘 | IRWIN D SPEZIO M WALKER L P | 1993 | Biotechnol Bioeng1993，42，： | 1 |
| 13 | A double-blind, crossover assessment of the sedative and analgesic effects of in- tranasal dexmedetomidine显示文摘 | YUEN V M IRWIN M G HUI T W | 2007 | Anesthesia and Analgesia2007，105，2： | 1 |
| 14 | Fish proglucagon genes have differing coding potential显示文摘 | Zhou L Irwin D M | 2004 | Comp Biochem Physiol2004，137，2： | 1 |
| 15 | An edge-based heuristic for steiner routing显示文摘 | M Borah R M Owens M J Irwin | 1994 | IEEE Trans Computer-Aided Des1994，13，： | 1 |
| 16 | Evolution of the cytochrome b gene of mammals显示文摘 | Irwin D M Kocher T D Wilson A C | 1991 | J Mol Evol1991，32，2： | 1 |
| 17 | Remifentanil preconditioning protects against ischemic injury in the intact rat heart显示文摘 | Zhang Y Irwin M G Wong T M | 2004 | Anesthesiology2004，101，： | 1 |
| 18 | Evolution of the cytochrome b gene of mammals显示文摘 | Irwin D M Kocher T D Wilson A C | 1991 | J Mol Evol1991，32，2： | 1 |
| 19 | Maintenance infliximab treat- ment is associated with improved bone mineral density in crohn' s disease 显示文摘 | Bernstein M Irwin S Grunberg G R | 2005 | Am J Gastroentem12005，100，9： | 1 |
| 20 | Immune correlates of depression显示文摘 | Irwin M | 1999 | Adv Exp Med Biol1999，461，1： | 1 |
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