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13篇 您的检索式：作者名="Irman"

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		题名	作者	年代	出处	被引量
	1	Methanolic extract of Abrus precatorius promotes breast cancer MDA-MB-231 cell death by inducing cell cycle arrest at G0/G1 and upregulating Bax显示文摘Objective:To determine the anti-proliferative activity of Abrus precatorius(A.precatorius)leaf extracts and their effect on cell death.Methods:A.precatorius leaves were extracted successively with hexane,ethyl acetate and methanol by Soxhlet extraction.Aqueous extract was prepared by decoction at 50 ℃.Extracts of A.precatorius leaves were used to treat selected cancer and normal cell lines for72 h.Furthermore,3-(4,5-dimethyl thiazol-2-yl)2,5-diphenyl tetrazolium bromide assay was performed to determine cell viability.Analysis of cell cycle arrest,apoptosis assay and apoptosis protein expressions were determined by flow cytometry.Results:Methanolic extract of A.precatorius leaves showed the lowest IC50 on MDA-MB-231 cells at(26.40±5.40)μg/mL.Flow cytometry analysis revealed that cell arrest occurred at G0/G1 phase and the apoptosis assay showed the occurrence of early apoptosis at 48 h in MDAMB-231 cells treated with methanolic extract of A.precatorius leaves.Methanolic extract of A.precatorius leaves induced apoptosis by upregulation of Bax,p53 and caspase-3 and downregulation of Bcl-2.Conclusions:Methanolic extract of A precatorius leaves promotes MDA-MB-231 cell death by inducing cell cycle arrest and apoptosis possibly via the mitochondrial-related pathway.	Wan Suriyani Wan-Ibrahim Norzila Ismail Siti Farhanah Mohd-Salleh Aidy Irman Yajid Michael Pak-KaiWong Mohd Nizam Md Hashim	2019	Asian Pacific Journal of Tropical Biomedicine2019，9，6：	2
	2	GA-based multiple paths test data generator 显示文摘	Moataz A Ahmed Irman Hermadi	2007	computer&operation research2007，1，12：	1
	3	Abnormal chondrocyte apoptosis in the cartilage growth plate is influenced by genetic background and deletion of CHOP in a targeted mouse model of pseudoachondroplasia显示文摘	Pirog K A Irman A Young S	2014	PLoS One2014，9，2：	1
	4	GA-based multiple paths test data generator显示文摘	Moataz A Ahmed Irman Hermadi	2008	Computers & Operations Research2008，，1：	1
	5	GA-based multiple paths test data generator显示文摘	Moataz A A Irman H	2008	Computers & Operations Research2008，35，：	1
	6	Quality control of an OSCE using gene-ralizalibility theory and many-faceted Rasch measurement显示文摘	Irmane etat C Yudkowsky R Myford CM	2008	Adv Health Sci Educ Theory Pract2008，13，4：	1
	7	Three-dimensional stress analysis of bolted single-lap compositejoints显示文摘	IRMAN T	1998	Composite Structures1998，，11：	1
	8	GA-based multiple paths test data gene-rator显示文摘	MOATAZ A A IRMAN H	2008	Computers & Operations Research2008，35，：	1
	9	Three-dimensional stress analysis of bolted single-lap composite joints显示文摘	Irman T		0，，：	1
	10	Extended Influence Diagrams for System Quality Analysis显示文摘	Johnson P Lagerstr(o)m R N(a)irman P	2007	Journal of Software2007，3，2：	1
	11	Controlling the dynamics of spontaneous emission from quantum dots by photonic crystals显示文摘	Lodahl P Floris Van Driel A Nikolaev I S Irman A Overgaag K Vanmaekelbergh D Vos W L		0，，7000：	1
	12	Crystallography and porosity effects of CO conversion on mesoporous CeO2 显示文摘	Mats Lundberg Bjorn Sk/irman L Reine Wallen- berg	2004	Microporous Mesoporous Mater2004，69，3：	1
	13	Alkaline-treated cocoa pod husk as adsorbent for removing methylene blue from aqueous solutions显示文摘	Fei ling Pua Mohd Shaiful Sajab Chin Hua Chia Sarani Zakaria Irman Abdul Rahman Mohd Sapuan Salit	2013	Journal of Environmental Chemical Engineering2013，，：	1

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