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| 1 | Long noncoding RNAs:a missing link in osteoporosis显示文摘Osteoporosis is a systemic disease that results in loss of bone density and increased fracture risk,particularly in the vertebrae and the hip.This condition and associated morbidity and mortality increase with population ageing.Long noncoding(lnc)RNAs are transcripts longer than 200 nucleotides that are not translated into proteins,but play important regulatory roles in transcriptional and post-transcriptional regulation.Their contribution to disease onset and development is increasingly recognized.Herein,we present an integrative revision on the studies that implicate lncRNAs in osteoporosis and that support their potential use as therapeutic tools.Firstly,current evidence on lncRNAs involvement in cellular and molecular mechanisms linked to osteoporosis and its major complication,fragility fractures,is reviewed.We analyze evidence of their roles in osteogenesis,osteoclastogenesis,and bone fracture healing events from human and animal model studies.Secondly,the potential of lncRNAs alterations at genetic and transcriptomic level are discussed as osteoporosis risk factors and as new circulating biomarkers for diagnosis.Finally,we conclude debating the possibilities,persisting difficulties,and future prospects of using lncRNAs in the treatment of osteoporosis. | Andreia Machado Silva Sara Reis Moura JoseHenrique Teixeira Mario Adolfo Barbosa Susana Gomes Santos Maria Ines Almeida | 2019 | Bone Research2019，7，1： | 13 |
| 2 | Preparation of Polycarbonate/Clay Nanocomposite and Characterization by X-Ray, Thermal Analyzes and Low-Field Nuclear Magnetic Resonance显示文摘 | Pedro Paulo Merat Maria Ines Bruno Tavares Emerson Oliveira da Silva | 2011 | 材料科学与工程(中英文A版)2011，1，5X： | 2 |
| 3 | Neutrophile-to-lymphocyte,lymphocyte-to-monocyte,and platelet-tolymphocyte ratios as prognostic and response biomarkers for resectable locally advanced gastric cancer显示文摘BACKGROUND Perioperative fluorouracil plus leucovorin,oxaliplatin,and docetaxel(FLOT)improves prognosis in locally advanced gastric cancer(LAGC).Neutrophil-to-lymphocyte(NLR),lymphocyte-tomonocyte(LMR),and platelet-to-lymphocyte(PLR)ratios are prognostic biomarkers but not predictive factors.AIM To assess blood ratios’(NLR,LMR and PLR)potential predictive response to FLOT and survival outcomes in resectable LAGC patients.METHODS This was a multicentric retrospective study investigating the clinical potential of NLR,LMR,and PLR in resectable LAGC patients,treated with at least one preoperative FLOT cycle,from 12 Portuguese hospitals.Means were compared through non-parametric Mann-Whitney tests.Receiver operating characteristic curve analysis defined the cut-off values as:High PLR>141 for progression and>144 for mortality;high LMR>3.56 for T stage regression(TSR).Poisson and Cox regression models the calculated relative risks/hazard ratios,using NLR,pathologic complete response,TSR,and tumor regression grade(TRG)as independent variables,and overall survival(OS)as the dependent variable.RESULTS This study included 295 patients(mean age,63.7 years;59.7% males).NLR was correlated with survival time(r=0.143,P=0.014).PLR was associated with systemic progression during FLOT(P=0.022)and mortality(P=0.013),with high PLR patients having a 2.2-times higher risk of progression[95% confidence interval(CI):0.89-5.26]and 1.5-times higher risk of mortality(95%CI:0.92-2.55).LMR was associated with TSR,and high LMR patients had a 1.4-times higher risk of achieving TSR(95%CI:1.01-1.99).OS benefit was found with TSR(P=0.015)and partial/complete TRG(P<0.001).Patients without TSR and with no evidence of pathological response had 2.1-times(95%CI:1.14-3.96)and 2.8-times(95%CI:1.6-5)higher risk of death.CONCLUSION Higher NLR is correlated with longer survival time.High LMR patients have a higher risk of decreasing T stage,whereas high PLR patients have higher odds of progressing under FLOT and dying.Patients with TSR and a pathological response have better OS and lower risk of dying. | Tiago Cruz Tomás Ines Eiriz Marina Vitorino Rodrigo Vicente Joao Gramaca Alicia Guadalupe Oliveira Paulo Luz Mafalda Baleiras Ana Sofia Spencer Luísa Leal Costa Patrícia Liu Joana Mendonca Magno Dinis Teresa Padrao Marisol Correia Goncalo Atalaia Michelle Silva Teresa Fiúza | 2022 | World Journal of Gastrointestinal Oncology2022，14，7： | 2 |
| 4 | Fatty acid synthase expression in squamous cell carcinoma of the tongue:clini- copathological findings显示文摘 | Silva SD Perez DE Nishimoto IN | 2008 | Oral Dis2008，14，4： | 1 |
| 5 | Laparoscopic Approach of a Unicornuate Uterus with Noncommunicating Rudimentary Horns显示文摘 | Lidia Rosi Medeiros Daniela Dornelles Rosa Fabio Rosa Silva Bruno Rosa Silva Maria Ines Rosa D. Chen N. A. Ginsberg | 2010 | ISRN Obstetrics and Gynecology2010，，： | 1 |
| 6 | Differential expression of an HSPT0 gene during transition from the mycelial to the infective yeast form of the human pathogenic fungus Paracoccidioides brasiliensis 显示文摘 | Silvana Petrofeza da Silva Maria Ines Borges Walmsley Iidinete Silva Pereira | 1999 | Molecular Microbiology1999，31，4： | 1 |
| 7 | Increased prevalence of early cochlear damage in young patients with type 1 diabetes detected by distortion product otoacoustic emissions 显示文摘 | Botelho CT Carvalho SA Silva IN | 2014 | Int J Audiol2014，53，6： | 1 |
| 8 | Oral alendronate treatment for se- vere polyostotic fibrous dysplasia due to McCune-Albright syndrome in a child: a case report 显示文摘 | Aragao AL Silva IN | 2010 | Int 3 Pediatr En- docrinol2010，2010，43： | 1 |
| 9 | Development of a device to measure bracket debonding force in vivo 显示文摘 | Prietsch JR Spohr AM Lima da Silva IN | 2007 | Eur J Orthod2007，29，6： | 1 |
| 10 | Risk factors for early onsetof diabetic nephropathy in pediatric type 1 diabetes显示文摘 | Salgado PP Silva IN Vieira EC et a1 | 2010 | J PediatrEndocrinol Metab2010，23，12： | 1 |
| 11 | Metabolic consequences of childhood obesity - a preliminary report 显示文摘 | de Silva KS Wickramasinghe VP Gooneratne IN | 2006 | Ceylon Med J2006，51，3： | 1 |
| 12 | Pericentrie Inversion of Chromosome 1 in Three Sterile Brothers 显示文摘 | Alejandro Giraldo Elizabeth Silva In Martinez | 1981 | Hum Genet1981，58，： | 1 |
| 13 | 15M NaCl solution 显示文摘 | Ferreira M G S Moura T E Silva Catarino A Electrochemical and Laser raman spectroscopy studies of stainless steel in 0 | 1992 | Journal of Electrochemical Society1992，139，11： | 1 |
| 14 | Oral alendronate treatment for severe poly- ostotic fibrous dysplasia due to McCune-Albright syndrome in a child: A case report显示文摘 | Aragao AL Silva IN | 2010 | Int J Pediatr Endocrinol2010，2010，43： | 1 |
| 15 | Randomiscd controlled trial of growth effect of hydrocortisone in congenital adrenal hyperplasia 显示文摘 | Silva IN Kater CE Cunha CF | 1997 | Arch Dis Child1997，77，3： | 1 |
| 16 | Evaluation of vertical transmission of Toxoplasma gondii in Calomys callosus model after reinfection with heterologous and virulent strain显示文摘 | Franco PS Silva DA Costam IN | 2010 | Placenta2010，36，8： | 1 |
| 17 | A cost-utility analysis of pregabalin versus venlafaxine XR in the treatment of generalized anxiety disorder in Portugal显示文摘 | Silva Miguel L Silva Miguel N In s M | 2013 | Cost Elf Resour Alloe2013，11，1： | 1 |
| 18 | ErbB2 and fatty acid synthase (FAS) expression in 102 squamous cell carcinomas of the tongue: Correlation with clinical outcomes显示文摘 | Sabrina D. Silva Danyel E. Perez Fabio A. Alves Inês N. Nishimoto Clóvis A.L. Pinto Luiz P. Kowalski Edgard Graner | 2007 | Oral Oncology2007，，5： | 1 |
| 19 | Effect of Graphene Nanoplatelets Presence on the Thermal and Mechanical Properties of Polypropylene Fibers Produced by Melt Spinning显示文摘In aiming to obtain fibers with enhanced thermal and mechanical properties,graphene based textile fibers with 144 filaments were developed using an approach in which the PP/GnP(polypropylene/graphene nanoplatelets)nanocomposite was employed as conductive material in a fiber with circular cross-section geometry.The kinetics of thermal degradation was evaluated by the Broido method using thermogravimetric analysis(TGA).Activation energy was enhanced from 260.6 kJ·mol^-1 to 337.4 kJ·mol^-1 compared to the neat PP.GnP increased the thermal stability of the PP,slowing its degradation by thermal depolymerization.Furthermore,the degree of crystallization declined as the GnP content increased,reducing the tenacity of the yarn,but improving its elastic modulus from 91.9 to 95.9 cN/tex,being a promising alternative to produce smart textiles.In conclusion,it has been confirmed that GnP loading up to 1%(w/w)can be incorporated into polypropylene by melt spinning and that the resulting nanocomposite fibers are suitable for several applications in the textile industry. | Ricardo Rodrigo Ramos Cecci Adriano Alves Passos Nathan Riany Valério Albino Daniel da Silva Vicente Ademir Severino Duarte Maria Inês Bruno Tavares | 2020 | 材料科学与工程(中英文B版)2020，10，2： | 1 |
| 20 | Fatty acid synthase expression in squamous cell carcinoma of the tongue: clinicopathological findings 显示文摘 | Silva SD Perez DE Nishimoto IN | 2008 | Oral Dis2008，14，4： | 1 |
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