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| 1 | 光激酶C基因突变导致的大头精子畸形是阿尔及利亚男性不育症的最常见遗传因素显示文摘克氏综合征和Y染色体微缺失是过去针对男性不育症仅有的两项基因检测分析技术。北非男性经常出现两种罕见的畸形精子症:大头和圆头精子畸形,推荐进行AURKC和DPYl9L2基因检测。对阿尔及利亚男性不育患者进行以上基因检测,评估两种畸形精子症的患病率,并与克氏综合征和Y染色体微缺失的频率进行比较。我们对阿尔及利亚君士坦丁市的IbnRochd医院辅助生殖中心进行不育症咨询的599名患者进行了回顾性研究,其中404人存在精液参数异常现象。14人和7人分别患有典型的大头精子畸形或圆头精子畸形,进而对这些患者进行了AURKC和DPYl9L2基因分析显示,11名大头精子畸形患者存在4URKC基因突变(79%),相当于所有精液异常人群的2.7%。而5名圆头精子畸形患者,相当于1.2%的不育症患者,均存在DPYl9L2基因缺失。通过比较,我们预测该人群中克氏综合症和Y染色体微缺失的患病率分别是1.6%和0.23%。我们的研究表明AURKC基因突变较克氏综合症更常见,它是导致北非男性不育的主要遗传因素。此外,本文也预测了AURKC和DP"觋2基因缺陷发生率分别是Y染色体微缺失发生率的10倍和5倍。 | Leyla Ounis Abdelali Zoghmar Charles Coutton Leila Rouabah Maroua Hachemil Delphine Martinez Guillaume Martinez Ines Bellil Douadi Khelifi Christophe Arnoult Julien Faure Sebti Benbouhedja Abdelkader Rouabah Pierre F Ray | 2015 | Asian Journal of Andrology2015，17，1： | 5 |
| 2 | The macrophage soluble receptor AIM/Api6/CD5L displays a broad pathogen recognition spectrum and is involved in early response to microbial aggression显示文摘巨噬细胞(目的) 的 Apoptosis 禁止者,人的 Spα 的一个相当或相同事物;,是一只老鼠 scavenger 受体的可溶的成员充满半胱氨酸的总科(SRCR-SF ) 。这个家庭集成没有统一功能还为被描述了的天生、适应的有免疫力的房间表示的一组蛋白质。多种的功能被归功于瞄准,从在在到在自体免疫的病理的类脂化合物新陈代谢和反煽动性的效果的 thymic 选择期间的淋巴细胞的生存能力支持。在现在的报告,目的病原体绑定性质被探索了。由使用在哺乳动物的细胞表示的目的(rAIM ) 的一种 recombinant 形式,这蛋白质能绑并且聚集克积极、克否定的细菌,以及病原、腐生的真菌的种类,这被显示出。重要地,浆液也绑在目的微生物和分泌物的从老鼠的内长的目的很快在跟随暴露到保存微生物引起的房间墙部件的老鼠怒气巨噬细胞被导致。老鼠 splenocytes 上的 ligands 也是的著名细菌、真菌的像使用费的受体(TLR ) 导致的 Cytokine 版本面对 rAIM 禁止了。而且,联系病原体的分子的模式(PAMP ) 的老鼠模型导致了腐败细菌、真菌的起源的吃惊证明浆液目的层次以一种时间依赖者方式变化了。总的来说,这些数据建议那个目的由在病原体侵略期间支持天生的体液的防卫起一个一般 homeostatic 作用。 | Vanesa G. Martinez Cristina Escoda-Ferran Ines Tadeu Simees Satoko Arai Marc Orta Mascaro Esther Carreras Mario Martinez-Florensa Jose Yelamos Toru Miyazaki Francisco Lozano | 2014 | Cellular & Molecular Immunology2014，11，4： | 2 |
| 3 | Pericentrie Inversion of Chromosome 1 in Three Sterile Brothers 显示文摘 | Alejandro Giraldo Elizabeth Silva In Martinez | 1981 | Hum Genet1981，58，： | 1 |
| 4 | Effect of selected aldehydes on the growth and fermentation of ethanolgenic Escherichia coli 显示文摘 | Zaldivar J Martinez A In gram L D | 1999 | Biotechnology and Bioengineering1999，65，1： | 1 |
| 5 | Appropriateness of Hospital Stays in a Pulmonolo- gy Department 显示文摘 | Rodriguez Francisco Campos Ines de la Cruz Moron Araceli Dlaz Martinez | 2007 | Arch Bronconeumol2007，43，8： | 1 |
| 6 | Preliminary results 显示文摘 | Gueli N Martinez A Verrusio W et aL Empirical anti- biotic therapy (ABT) of lower respiratory tract infections (LRTI) in the elderly: application of artificial neural net- work (ANN) | 2012 | Archives of Geron- tology and Geriatrics2012，55，2： | 1 |
| 7 | Evaluation of eye rritation of arginine-derivative surfactants using difvitro end 显示文摘 | Martinez and skin ferent in V Corsini E Mitjans M | 2006 | ToxicoI Lett points as alternatives to the in vivo assays2006，164，3： | 1 |
| 8 | Tumor thymidylate synthase 1494de16 genotype as a prognostic factor in colorectal cancer patients receiving fluorouracil-based adjuvant treatment显示文摘 | Dotor E cuatrecasesm martinez in IESTA M | 2006 | J Clin Oncol2006，24，10： | 1 |
| 9 | Fi- validation of wear modeling 显示文摘 | MARTINEZ F J CANALES M nite element implementation and in sliding polymer-metal contacts IZQUIERDO S | 2012 | Wear2012，，284285： | 1 |
| 10 | Energy Efficiency and CO2 Emissions in Swedish Manufacturing Industries显示文摘 | Clara Ines Pardo Martinez Semida Silveira | 2013 | Energy Efficiency2013，，6： | 1 |
| 11 | Influence of Stainless Steel Weld Microstructure on Its Seawater Corrosion Performance显示文摘 | Santilláin Néstor Valdez Benjamin Schorr Miguel Carrillo Mónica Martinez Alejandro Colton Samuel | 2011 | 材料科学与工程(中英文版)2011，5，1： | 0 |
| 12 | Higher cardiovascular risk scores and liver fibrosis risk estimated by biomarkers in patients with metabolic-dysfunction-associated fatty liver disease显示文摘BACKGROUND The definition of metabolic-dysfunction-associated fatty liver disease(MAFLD)allows identification of metabolically complicated patients.Fibrosis risk scores are related to cardiovascular risk(CVR)scores and could be useful for the identification of patients at risk of systemic complications.AIM To evaluate the relationship between MAFLD and CVR using the Framingham risk score in a group of Mexican patients.METHODS Cross-sectional,observational and descriptive study carried out in a cohort of 585 volunteers in the state of Veracruz with MAFLD criteria.The risk of liver fibrosis was calculated with aspartate aminotransferase-to-platelet ratio index,nonalcoholic fatty liver disease score and fibrosis-4,as well as with transient hepatic elastography with Fibroscan~?.The CVR was determined by the Framingham system.RESULTS One hundred and twenty-five participants(21.4%)with MAFLD criteria were evaluated,average age 54.4 years,63.2%were women,body mass index 32.3 kg/m~2.The Framingham CVR was high in 43 patients(33.9%).Transient elastography was performed in 55.2%of volunteers;39.1%with high CVR and predominance in advanced fibrosis(F3–F4).The logistic regression analysis showed that liver fibrosis,diabetes and hypertension independently increased CVR.CONCLUSION One of every three patients with MAFLD had a high CVR,and in those with high fibrosis risk,the CVR risk was even greater. | Giovanni Alejandro Salgado Alvarez Samanta Mayanin Pinto Galvez Uriel Garcia Mora Ana Delfina Cano Contreras Cristina Durán Rosas Bryan Adrián Priego-Parra Arturo Triana Romero Mercedes Amieva Balmori Federico Roesch Dietlen Sophia Eugenia Martinez Vazquez Ines Osvely Mendez Guerrero Luis Alberto Chi-Cervera Raúl Bernal Reyes Leonardo Alberto Martinez Roriguez Maria Eugenia Icaza Chavez Jose Maria Remes Troche | 2022 | World Journal of Hepatology2022，14，8： | 0 |
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