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| 1 | VEGF-D expression correlates with colorectal cancer aggressiveness and is downregulated by cetuximab显示文摘AIM:To gain mechanistic insights into the role played by epidermal growth factor receptor (EGFR) in the regulation of vascular endothelial growth factors (VEGFs) in colorectal cancer (CRC). METHODS:The impact of high-level expression of the growth factor receptors EGFR and VEGF receptor (VEGFR)3 and the VEGFR3 ligands VEGF-C and VEGF-D on disease progression and prognosis in human CRC was investigated in 108 patients using immunohistochemistry. Furthermore, the expression of the lymphangiogenic factors in response to the modulation of EGFR signalling by the EGFR-targeted monoclonal antibody cetuximab was investigated at the mRNA and protein level in human SW480 and SW620 CRC cell lines and a mouse xenograft model. RESULTS: Human CRC specimens and cell lines displayed EGFR, VEGF-C and VEGF-D expression with varying intensities. VEGF-C expression was associated with histological grade. Strong expression of VEGF-D was significantly associated with lymph node metastases and linked to a trend for decreased survival in lymph node-positive patients. EGFR blockade with cetuximab resulted in a significant decrease of VEGF-D expression in vitro and in vivo. CONCLUSION:In conclusion, the expression of VEGF-D in colorectal tumours is significantly associated with lymphatic involvement in CRC patients and such expression might be blocked effectively by cetuximab. | Markus Moehler Christian Frings Annett Mueller Ines Gockel Carl C Schimanski Stefan Biesterfeld Institute of Pathology Johannes Gutenberg University Mainz 55101 Germany Peter R Galle Martin H Holtmann | 2008 | World Journal of Gastroenterology2008，14，26： | 15 |
| 2 | Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. | Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 3 | Molecular analysis of the root canal microbiota associated with endodontic treatment failures显示文摘 | Sakamoto M Siqueira JF Jr R(o)(c)as IN | 2008 | Oral Microbiol Immunol2008，23，4： | 1 |
| 4 | Safety and adult volunteers of a human papillomavirus 16 L1 virus-like particle vaccine显示文摘 | Harro C D Pang Y Y immunogenicity trial in Roden R B | 2001 | J Natl Cancer Inst2001，93，4： | 1 |
| 5 | Some basic fracture mechanics concepts in functionally graded materials显示文摘 | IN Z H BATRA R C | 1996 | J Mech Phys Solids1996，44，： | 1 |
| 6 | DDT-induced oxidative damage in human blood mononuclear cells 显示文摘 | Pérez-Maldonado IN Herrera C Batres LE González-Amaro R Díaz-Barriga F Yá?ez L | 2005 | Environ Res2005，98，2： | 1 |
| 7 | Biochemical aspects of the metabolism alteration process syndrome显示文摘 | Petibois C Cazorla G Poortmans overtraining in endurance sporls J R | 2003 | Sports Med2003，33，2： | 1 |
| 8 | elegans developing embryos显示文摘 | Daniels B R Masi B C Wirtz D Probing single-cell micromechanics in vivo: the microrheology of C | 2006 | Biophys J2006，90，： | 1 |
| 9 | Establishment of the optimum initial xylose concentration and nutritional supplementation of brewer's spent grain hydrolysate for xylitol production by Candida guilliermondii显示文摘 | Solange I M Ines C R | 2008 | Process Biochemistry2008，43，： | 1 |
| 10 | Alternatives for detoxification of diluted-acid lignocellulosic hydrolysates for use in fermentative processes:A review显示文摘 | SOLANGE I M INES C R | 2004 | Bioresource Technology2004，93，： | 1 |
| 11 | - implications for con- servation and restoration显示文摘 | ORTH R J HARWELL M C BAILEY E M et ak A review of issues in seagrass seed dormancy and germination | 2000 | Marine Ecology Progress Series2000，200，： | 1 |
| 12 | Isolation,characterisation and mapping of simple sequence repeat loci in potato显示文摘 | Milbourne D Meyer R C Col ins A J | | 0，，： | 1 |
| 13 | 6P challenge in DNA/MVA- vaecinated macaques显示文摘 | AMARA R R IBEGBU C VILLINGER F et ahStudies using a viral challenge and CD8 T cell depletions on the roles of cellular and humoral immunity in the control of an SHIV-89 | 2005 | Virology2005，343，2： | 1 |
| 14 | 显示文摘 | Baldelli R Dieguez C Casanueva FE The role of leptin in reproduction: experimental and clinical aspects | 2009 | Annals of Medicine2009，34，1： | 1 |
| 15 | The analysis of fluorescent whitening agents using reversed-phase HPLC and mass spectrometry显示文摘 | SANTOS M NER'IN C BATLLE R | 2004 | Lcgc North America2004，22，： | 1 |
| 16 | A convenient synthesis of symmetrical and unsymmetrical 1,2-b is(phosphino) benzenesas ligands for transition m etals显示文摘 | Kyba E P K e rb y M C R ines S P | 1986 | Organometallics1986，5，： | 1 |
| 17 | Succession of Hydrocarbon-Degrading Bacteria in the Aftermath of the Deepwater Horizon Oil Spill in the Gulf of Mexico 显示文摘 | Dubinsky E A Conrad M E Chakraborty R Bill M Borg Hollibaugh J T Mason O U M Piceno Y Reid F C Stringfcllow W T Tom L M Hazen T C Andersen G L | 2013 | Environ Sei Technol2013，47，10： | 1 |
| 18 | In te r n a tio n a l c o lla b o ra tio nin m e d ic a l r e s e a r c h in L a tin A m e ric a a n d th eC a r ib b e a n ( 2003-2007 ) 显示文摘 | C h in c h illa -R o d rig u e z Z B e n a v e n t-P e re z M M o y a -A n e g o n F e t a l | 2012 | J o u r n a l o f th e A me r ic a n S o c ie ty fo r In fo rm a tio n S c ie n c e a n dT e c h n o lo g y2012，63，11： | 1 |
| 19 | Sixteen years' experience with long-term follow-up显示文摘 | Flynn J C Matthews J G Benoit R L Blind pinning of displaced supracondylar fractures of the humerus in children | 1974 | JBone Joint Surg Am1974，56，2： | 1 |
| 20 | Effective inhibition of nickel TiNi alloy and its cyto- 显示文摘 | Zhao T Yang R Zhong C release by tantalum-implanted compatibility evaluation in vitro 2529-2535 | 2011 | J Mater Sci2011，46，8： | 1 |
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