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| 1 | Overexpression of TLR3, TLR4, TLR7 and TLR9 in esophageal squamous cell carcinoma显示文摘AIM: To investigate the expression of Toll-like receptor (TLR) 3, TLR4, TLR7 and TLR9 in esophageal squamous cell carcinoma (ESCC). METHODS: Reverse transcription-polymerase chain reaction and immunohistochemistry were used to analyze the expression of TLR3, TLR4, TLR7 and TLR9 mRNA and protein in samples from 87 esophageal cancer patients consisting of both tumor and normal tissue. RESULTS: A significant increase in TLR3, TLR4, TLR7 and TLR9 mRNA levels was detected in ESCC samples. Tumors exhibited high TLR protein expression, (70.1%, 72.4%, 66.7% and 78.2% for TLR3, TLR4, TLR7 and TLR9, respectively, P < 0.05). Nevertheless, a significant percentage of tumors also exhibited TLR4 expression in mononuclear inflammatory cells (48.3%) and TLR9 expression in fibroblast-like cells (60.9%). Tumors with high TLR3 expression in tumor cells or high TLR4 expression in mononuclear inflammatory cells were significantly associated with a higher probability of lymph node metastasis and increased depth of invasion. However, tumors with high TLR9 expression in fibroblast-like cells were associated with low probabilities of invasion and metastasis. There was no significant variation between the expression of TLR3, TLR4, TLR7 and TLR9 among different ethnic groups. CONCLUSION: TLR3, TLR4, TLR7 and TLR9 expression appears important to the biological pathogenesis of ESCC. TLRs may represent therapeutic targets for ESCC. | Ilyar Sheyhidin Gulnaz Nabi Ayshamgul Hasim Rui-Ping Zhang Julaiti Ainiwaer Hong Ma Hua Wang | 2011 | World Journal of Gastroenterology2011，17，32： | 22 |
| 2 | Association of defective HLA-Ⅰ expression with antigen processing machinery and their association with clinicopathological characteristics in Kazak patients with esophageal cancer显示文摘背景它被证实了分子能贡献的人的白血球抗原班(HLA-) 的那个有缺点的表达式在癌症的一些类型的癌症房间的有免疫力的避免。这研究的目的是在高风险人乳头状瘤病毒( HPV )在食道的有鳞的房间癌( ESCC )和他们的角色检验 HLA 班抗原和处理抗原的机械( APM )部件的表示感染,并且 50 修理福尔马林的、嵌入石蜡的 ESCC 损害的一个总数从 Xinjiang 医药大学的首先隶属于的医院被收集在 Kazak 种族 group.Methods 与组织病理学说的特征分析他们的协会,中国。HLA- 抗原和 APM 部件的表示层次被 immunohistochemistry 决定;HPV DNA 用聚合酶链反应(PCR ) 被检测下面规定的高频率或 HLA 和 APM 部件的表示的损失在 Kazak 人在食道的癌症被发现的 .Results。HLA- , TAP1, CNX, LMP7, Erp57, Tapasin 和 ERAP1 在 68%,44% 是下面调整的, 48% ESCC, 40% , 52% , 32% 和 20% 损害然后分别地。HLA- 抗原的表示的损失显著地与 APM 部件的部分被相关并且断然与高风险 HPV16 感染相关。 TAP1 , CNX , LMP7 , Erp57 和 Tapasin 损失显著地与肿瘤分级,淋巴节点转移和侵略( P0.05 )的深度被联系我们的结果建议的 .Conclusion APM 部件背叛,这是在 ESCC 损害位于HLA-抗原下面规定下面的机制,并且显示HLA-和 APM 部件的损失表示将成为 ESCC 的一个重要标记和HLA-和 APM 部件表示的分析能从 Kazak eth 为病人向有用预示的信息提供 | Ayshamgul Hasim MA Hong Ilyar Sheyhidin ZHANG Li-wei Abulizi Abudula | 2011 | Chinese Medical Journal2011，，3： | 12 |
| 3 | Plasma free amino acid profiling of esophageal cancer using high-performance liquid chromatography spectroscopy显示文摘AIM:To perform plasma free amino acid(PFAA)profiling of esophageal squamous cell carcinoma(ESCC)patients at different pathological stages and healthy subjects.METHODS:Plasma samples from ESCC patients(n=51)and healthy control adults(n=60)were analyzed by high-performance liquid chromatography(HPLC).The ESCC patients included moderate/poorly-differentiation(n=24),lymph node metastasis(n=17)and clinical stage>Ib2(n=36).Partial least squares discriminant analysis was performed to demonstrate that the PFAA metabolic patterns enabled discrimination between ESCC patients and controls,and the Student t test was applied to assess significant differences in PFAA concentrations between the two groups.RESULTS:There were significant differences in the PFAA profiles between controls and ESCC patients.Compared with healthy controls,the levels of Asp,Glu,Gly,His,Thr,Tau,Ala,Met,Ile,Leu,and Phe were decreased in ESCC patients,but Cys was increased.There exists a strong correlation between PFAA profiles and clinicopathological characteristics in ESCC patients.The levels of many PFAAs(i.e.,Glu,Asp,Ser,Gly,Tau,Ala,Tyr,Val,Ile,and Leu)were related to pathological grading,lymph node metastasis,and ESCC clinical stage.Very good discrimination between ESCC patients and control subjects was achieved by multivariate modeling of plasma profiles.CONCLUSION:HPLC-based plasma profiling analysis was shown to be an effective approach to differentiate between ESCC patients and controls.PFAA profiles may have potential value for screening or diagnosing ESCC. | Hong Ma Ayshamgul Hasim Batur Mamtimin Bin Kong Hai-Ping Zhang Ilyar Sheyhidin | 2014 | World Journal of Gastroenterology2014，20，26： | 11 |
| 4 | Decreased blood riboflavin levels are correlated with defective expression of RFT2 gene in gastric cancer显示文摘AIM:To investigate the relationship between blood riboflavin levels and riboflavin transporter 2(RFT2) gene expression in gastric carcinoma(GC) development.METHODS:High-performance liquid chromatography was used to detect blood riboflavin levels in patients with GC.Real-time fluorogenic quantitative polymerase chain reaction and immunohistochemistry were used to analyze the expression of RFT2 mRNA and protein in samples from 60 GC patients consisting of both tumor and normal tissue.RESULTS:A significant decrease in the RFT2 mRNA levels was detected in GC samples compared with those in the normal mucous membrane(0.398 ± 0.149 vs 1.479 ± 0.587;P = 0.040).Tumors exhibited low RFT2 protein expression(75%,16.7%,8.3% and 0% for no RFT2 staining,weak staining,medium staining and strong staining,respectively),which was significantly lower than that in the normal mucous membrane(10%,16.7%,26.7% and 46.7% for no RFT2 staining,weak staining,medium staining and strong staining,respectively;P < 0.05).Tumors with low RFT2 expression were significantly associated with tumor stage and histological grade.Moreover,a significantly decrease in Uyghur patients was observed compared with Han patients.However,other parameters-gender,tumor location and lymph node metastasis-showed no significant relationship with RFT2 expression.Blood riboflavin levels were reverse correlated with development of GC(1.2000 ± 0.97 569 ng/mL in high tumor stage patients vs 2.5980 ± 1.31 129 ng/mL in low tumor stage patients;P < 0.05).A positive correlation of plasma riboflavin levels with defective expression of RFT2 protein was found in GC patients(2 = 2.619;P = 0.019).CONCLUSION:Defective expression of RFT2 is associated with the development of GC and this may represent a mechanism underlying the decreased plasma riboflavin levels in GC. | Maynur Eli De-Sheng Li Wei-Wei Zhang Bing Kong Chen-Song Du Maimaitiaili Wumar Batur Mamtimin Ilyar Sheyhidin Ayshamgul Hasim | 2012 | World Journal of Gastroenterology2012，18，24： | 6 |
| 5 | DNA polymorphism and risk of esophageal squamous cell carcinoma in a population of North Xinjiang,China显示文摘AIM:To investigate the role of metabolic enzyme and DNA repair genes in susceptibility of esophageal squamous cell carcinoma(ESCC). METHODS:A case-control study was designed with 454 samples from 128 ESCC patients and 326 gender, age and ethnicity-matched control subjects.Genotypes of 69 single nucleotide polymorphisms(SNPs)of metabolic enzyme(aldehyde dehydrogenase-2,ALDH2; alcohol dehydrogenase-1 B,ADHB1;Cytochrome P450 2A6,CYP2A6)and DNA repair capacity genes(excision repair cross complementing group 1,ERCC1; O 6-methylguanine DNA methyltransferase,MGMT; xeroderma pigmentosum group A,XPA;xeroderma pigmentosum group A,XPD)were determined by the Sequenom MassARRAY system,and results were analyzed using unconditional logistic regression adjusted for age,gender. RESULTS:There was no association between the variation in the ERCC1,XPA,ADHB1 genes and ESCC risk.Increased risk of ESCC was suggested in ALDH2 for frequency of presence C allele of SNP [Rs886205:1.626(1.158-2.284)],XPD for C allele [Rs50872:1.482(1.058-2.074)],and MGMT for A allele[Rs11016897:1.666(1.245-2.228)].Five variants of MGMT were associated with a protective effect on ESCC carcinogenesis,including C allele [Rs7069143:0.698(0.518-0.939)],C allele[Rs3793909: 0.6 5 3(0.4 2 9-0.9 9 5)],A a l l e l e[R s 1 2 7 7 1 8 8 2: 0.719(0.524-0.986)],C allele[Rs551491:0.707 (0.529-0.945)],and A allele[Rs7071825:0.618 (0.506-0.910)].At the genotype level,increased risk of ESCC carcinogenesis was found in homozygous carriers of the ALDH2 Rs886205[CC vs TT,odds ratios(OR): 3.116,95%CI:1.179-8.234],MGMT Rs11016879(AA vs GG,OR:3.112,95%CI:1.565-6.181),Rs12771882 (AA vs GG,OR:2.442,95%CI:1.204-4.595),and heterozygotes carriers of the ALDH2 Rs886205 (CT vs TT,OR:3.930,95%CI:1.470-10.504), MGMT Rs11016879(AG vs GG,OR:3.933,95%CI: 2.216-6.982)and Rs7075748(CT vs CC,OR:1.949, 95%CI:1.134-3.350),respectively.Three variants were associated with a protective effect on ESCC carcinogenesis,carriers of the MGMT Rs11016878(AG vs AA,OR:0.388,95%CI:0.180-0.836),Rs7069143(CT vs CC,OR:0.478,95%CI:0.303-0.754)and Rs7071825(GG vs AA,OR:0.493,95%CI:0.266-0.915). Increased risk of ESCC metastasis was indicated in MGMT for frequency of presence C allele[Rs7068306: 2.204(1.244-3.906)],A allele[Rs10734088:1.968 (1.111-3.484)]and C allele[Rs4751115:2.178(1.251-3.791)].Two variants in frequency of presence C allele of CYP2A6[Rs8192720:0.290(0.099-0.855)] and A allele of MGMT[Rs2053139:0.511(0.289-0.903)] were associated with a protective effect on ESCC progression.Increased risk of ESCC metastasis was found in heterozygote carriers of the MGMT Rs7068306 (CG vs CC,OR:4.706,95%CI:1.872-11.833).CONCLUSION:Polymorphic variation in ALDH2,XPD and MGMT genes may be of importance for ESCC susceptibility.Polymorphic variation in CYP2A6 and MGMT are associated with ESCC metastasis. | Ilyar Sheyhidin | 2010 | World Journal of Gastroenterology2010，16，5： | 3 |
| 6 | HMGA 2 is down‐regulated by micro RNA let‐7 and associated with epithelial–mesenchymal transition in oesophageal squamous cell carcinomas of K azakhs显示文摘 | Qing Liu Tao Liu Shutao Zheng Xiangpeng Gao Mang Lu Ilyar Sheyhidin Xiaomei Lu | 2014 | Histopathology2014，，： | 1 |
| 7 | Clinicopathological pattern and Annexin A2 and Cdc42 status in patients presenting with differentiation and lymphnode metastasis of esophageal squamous cell carcinomas显示文摘 | Jun-guo Feng Qing Liu Xu Qin Yue-hua Geng Shu-tao Zheng Tao Liu Ilyar Sheyhidin Xiao-mei Lu | 2012 | Molecular Biology Reports2012，，2： | 1 |
| 8 | Surgical treatment of pericardial echinococcosis: report of eight cases显示文摘Echinococcosis is a human parasitic disease common in sheep-rearing regions.It is caused by the larval stage of Echinococcus granulosus.In humans,the most frequent locations of the hydatid cysts are the liver and lungs;1 pericardial echinococcosis is extremely rare.2Only 8 cases of pericardial echinococcosis occurred in approximately 7000 cardiac operations during 31 years in our hospital.We herein reported our surgical treatment experience and provide diagnostic and therapeutic recommendations for pericardial echinococcosis. | ZHENG Feng WANG Xuan MA Song-feng QIAO Jun Ilyar Sheyhidin | 2013 | Chinese Medical Journal2013，，3： | 0 |
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