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| 1 | 嘌呤信号通路对成熟神经祖细胞功能的调节显示文摘细胞外的嘌呤是胚胎发育过程中脑和脊髓原位内的信号分子,它们通过激活胚胎神经干细胞(NSCs)及成熟神经祖细胞(NPCs)表面的嘌呤受体发挥作用。虽然NSCs/NPCs内表达了能和几乎所有核苷酸敏感型P2X/P2Y受体和核酸敏感型腺苷受体相作用的m RNA和蛋白,但其中只有一部分具有功能。ATP被异位核苷酸酶依次降解为ADP,AMP和腺苷,它们都是神经激动剂并作用于不同类型的受体。核苷酸/核苷促进或抑制NSC/NPC增殖、迁移和分化。所有激动剂(特别是ATP和ADP)的最普遍的作用是促进细胞增殖,常通过P2Y1Rs,有时也通过P2X7Rs。但P2X7R的激活通常导致NPCs的坏死或凋亡。激活P2Y2R或阻断P2X7R可促进神经细胞的分化。转导机制的核心是细胞内游离钙离子浓度的升高,游离的钙离子可能来自细胞内的释放(G蛋白偶联;P2Y),或细胞外的钙离子通过被激活的受体通道进入细胞内(ATP门控离子通道;P2X)。进一步的研究将着重阐明嘌呤信号通道如何调控NSC/NPC的分化,以及静息和活化状态之间的平衡如何通过精细和动态的调节来建立。 | Yong Tang Peter Illes 唐颖馨(编译) | 2017 | 神经损伤与功能重建2017，12，2： | 4 |
| 2 | 嘌呤信号与针灸镇痛显示文摘疼痛是针灸的优势适应症。解析针灸镇痛的机制是一个具有理论和现实意义的重要挑战。继Geoffrey Burnstock提出嘌呤信号参与针灸镇痛的假说以及Maiken Nedergaard证实穴位局部腺苷受体介导针刺镇痛之后,嘌呤信号成为近年来针灸镇痛的研究热点。因此,本文将对嘌呤信号与针灸镇痛的系列研究进行总结以及展望。 | 黄露梅 刘娟 尹海燕 余曙光 Patrizia Rubini Peter Illes 唐勇 | 2016 | 成都中医药大学学报2016，39，4： | 4 |
| 3 | Purinergic Receptors in Basal Ganglia Diseases:Shared Molecular Mechanisms between Huntington’s and Parkinson’s Disease显示文摘Huntington’s(HD)and Parkinson’s diseases(PD)are neurodegenerative disorders caused by the death of GABAergic and dopaminergic neurons in the basal ganglia leading to hyperkinetic and hypokinetic symptoms,respectively.We review here the participation of purinergic receptors through intracellular Ca^2+signaling in these neurodegenerative diseases.The adenosine A2A receptor stimulates striatopallidal GABAergic neurons,resulting in inhibitory actions on GABAergic neurons of the globus pallidus.A2A and dopamine D2 receptors form functional heteromeric complexes inducing allosteric inhibition,and A2A receptor activation results in motor inhibition.Furthermore,the A2A receptor physically and functionally interacts with glutamate receptors,mainly with the mGlu5 receptor subtype.This interaction facilitates glutamate release,resulting in NMDA glutamate receptor activation and an increase of Ca2+influx.P2X7 receptor activation also promotes glutamate release and neuronal damage.Thus,modulation of purinergic receptor activity,such as A2A and P2X7 receptors,and subsequent aberrant Ca^2+signaling,might present interesting therapeutic potential for HD and PD. | Talita Glaser Roberta Andrejew Agatha Oliveira-Giacomelli Deidiane Elisa Ribeiro Lucas Bonfim Marques Qing Ye Wen-Jing Ren Alexey Semyanov Peter Illes Yong Tang Henning Ulrich | 2020 | Neuroscience Bulletin2020，36，11： | 3 |
| 4 | Impaired ATP Release from Brain Astrocytes May be a Cause of Major Depression显示文摘Major depressive disease(MDD)is one of the most common mental disorders and a leading cause of disability[1].Core symptoms include depressed mood,increased apathy,and a general loss of interest.In consequence,it represents not only a personal hardship for the patients themselves,but also a major socio-economic burden for society as a whole. | Peter Illes Patrizia Rubini Haiyan Yin Yong Tang | 2020 | Neuroscience Bulletin2020，36，11： | 2 |
| 5 | Self-organizing pedestrian movement显示文摘 | Dirk Helbing Peter Molnar Illes J Farkas | | 0，，： | 1 |
| 6 | Affect and Decision Making: A 'hot' Topic 显示文摘 | Peters E V~ffj~ill D G~ling T Slovic P | 2006 | Journal of Behavioral and Decision Making2006，19，： | 1 |
| 7 | Simulation of pedestrian crowds in normal and evacuation situations显示文摘 | Dirk Helbing Illes J Farkas Peter Molnar | 2002 | Pedestrian and Evacuation Dynamics2002，，： | 1 |
| 8 | From purines to purinergic signalling:molecular functions and human diseases显示文摘Purines and their derivatives,most notably adenosine and ATP,are the key molecules controlling intracellular energy homoeostasis and nucleotide synthesis.Besides,these purines support,as chemical messengers,purinergic transmission throughout tissues and species.Purines act as endogenous ligands that bind to and activate plasmalemmal purinoceptors,which mediate extracellular communication referred to as“purinergic signalling”.Purinergic signalling is cross-linked with other transmitter networks to coordinate numerous aspects of cell behaviour such as proliferation,differentiation,migration,apoptosis and other physiological processes critical for the proper function of organisms.Pathological deregulation of purinergic signalling contributes to various diseases including neurodegeneration,rheumatic immune diseases,inflammation,and cancer.Particularly,gout is one of the most prevalent purine-related disease caused by purine metabolism disorder and consequent hyperuricemia.Compelling evidence indicates that purinoceptors are potential therapeutic targets,with specific purinergic agonists and antagonists demonstrating prominent therapeutic potential.Furthermore,dietary and herbal interventions help to restore and balance purine metabolism,thus addressing the importance of a healthy lifestyle in the prevention and relief of human disorders.Profound understanding of molecular mechanisms of purinergic signalling provides new and exciting insights into the treatment of human diseases. | Zhao Huang Na Xie Peter Illes Francesco Di Virgilio Henning Ulrich Alexey Semyanov Alexei Verkhratsky Beata Sperlagh Shu-Guang Yu Canhua Huang Yong Tang | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 1 |
| 9 | P2X7 receptor: an emerging target in central nervous system diseases显示文摘 | Beata Sperldgh Peter Illes | 2014 | Trends Pharmacol Sci2014，35，： | 1 |
| 10 | Therapy of acute wounds with water-filtered infrared-A (wIRA)显示文摘 | Hartel Mark Illing Peter Mercer James B | 2007 | GMS Krankenhaushygiene Interdisziplinar2007，2，2： | 1 |
| 11 | P2X receptors and nociception显示文摘 | Chizh BA Peter Illes | 2000 | Pharmacol Rev2000，53，： | 1 |
| 12 | Effects of pretreatment with clopidogrol and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study 显示文摘 | Mehta SR Yusuf S Peters ILl | 2001 | Lancet2001，358，921： | 1 |
| 13 | P2 receptors and neuronal injury显示文摘 | Heike Franke Ute Krügel Peter Illes | 2006 | Pflügers Archiv - European Journal of Physiology2006，，5： | 1 |
| 14 | Two rings in them all:The labdane-related diterpenoids显示文摘 | Peters ILl | 2010 | Nat Prod Rep2010，，： | 1 |
| 15 | P2X 7 receptor-mRNA and -protein in the mouse retina; changes during retinal degeneration in BALBC rds mice显示文摘 | Heike Franke Kerstin Klimke Ute Brinckmann Jens Grosche Mike Francke Beata Sperlagh Andreas Reichenbach Uwe Gerd Liebert Peter Illes | 2005 | Neurochemistry International2005，，4： | 1 |
| 16 | P2X7 Receptor Expression after Ischemia in the Cerebral Cortex of Rats显示文摘 | HEIKE FRANKE ALBRECHT GüNTHER JENS GROSCHE RENATE SCHMIDT STEFFEN ROSSNER ROBERT REINHARDT HEIDI FABER-ZUSCHRATTER DIETMAR SCHNEIDER PETER ILLES | 2004 | JNEN: Journal of Neuropathology & Experimental Neurology2004，，7： | 1 |
| 17 | Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early- stage cancer of the cervix显示文摘 | Peters WA Liu PY Barrett ILl | 2000 | J Clin Oneol2000，18，8： | 1 |
| 18 | Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study 显示文摘 | Mehta SR Yusuf S Peters ILl | 2001 | Lancet2001，358，9281： | 1 |
| 19 | Effects of pretreatment with clo- pidogrel and aspirin followed by long - term therapy in patients undergo- ing percutaneous coronary intervention : the PCI - CURE study 显示文摘 | Mehta SR Yusuf S Peters ILl | 2001 | Lancet2001，358，9281： | 1 |
| 20 | Simulation of pedestrian crowds in normal and evacuation situations 显示文摘 | Dirk Helbing Illes J Farkas Peter Molnar | 2002 | Pedestrian and Evacuation Dynamics2002，，： | 1 |
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