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| 1 | Peutz-Jeghers syndrome:Diagnostic and therapeutic approach显示文摘Peutz-Jeghers syndrome(PJS)is an inherited,autosomal dominant disorder distinguished by hamartomatous polyps in the gastrointestinal tract and pigmented mucocutaneous lesions.Prevalence of PJS is estimated from 1 in 8300 to 1 in 280 000 individuals.PJS predisposes sufferers to various malignancies(gastrointestinal,pancreatic,lung,breast,uterine,ovarian and testicular tumors).Bleeding,obstruction and intussusception are common complications in patients with PJS.Double balloon enteroscopy(DBE)allows examination and treatment of the small bowel.Polypectomy using DBE may obviate the need for repeated urgent operations and small bowel resection that leads to short bowel syndrome.Prophylaxis and polypectomy of the entire small bowel is the gold standard in PJS patients.Intraoperative enteroscopy(IOE)was the only possibility for endoscopic treatment of patients with PJS before the DBE era.Both DBE and IOE facilitate exploration and treatment of the small intestine. DBE is less invasive and more convenient for the pa- tient.Both procedures are generally safe and useful. An overall recommendation for PJS patients includes not only gastrointestinal multiple polyp resolution,but also regular lifelong cancer screening(colonoscopy, upper endoscopy,computed tomography,magnetic resonance imaging or ultrasound of the pancreas, chest X-ray,mammography and pelvic examinationwith ultrasound in women,and testicular examination in men).Although the incidence of PJS is low,it is important for clinicians to recognize these disorders to prevent morbidity and mortality in these patients,and to perform presymptomatic testing in the first-degree relatives of PJS patients. | Marcela Kopacova Ilja Tacheci Stanislav Rejchrt Jan Bures | 2009 | World Journal of Gastroenterology2009，15，43： | 45 |
| 2 | Double balloon enteroscopy and acute pancreatitis显示文摘Double balloon enteroscopy(DBE)is a new technique, first published and introduced into clinical practice in 2001 by Yamamoto,the inventor of this outstanding method.DBE allows complete visualization,biopsy and treatment of the small bowel.Nowadays,we have some experience of this method for evaluation of the complica- tion rate.Severe complications are described in 1%-1.7% of patients.Acute pancreatitis is a rare complication of the investigation.The incidence of acute pancreatitis after diagnostic DBE is 0.3%in most studies.More than 50 cases of acute pancreatitis have been described in the literature so far.On the contrary,hyperamylasemia after DBE seems to be a rather common condition.Association with acute pancreatitis is supposed to be possible,but not obligatory.The causal mechanism of post-DBE acute pancreatitis is uncertain,and there are several theories in the literature.The most probable cause seems to be a mechanical straining of the endoscope with over-tube on the pancreas or in the papillary area. | Marcela Kopacova Ilja Tacheci Stanislav Rejchrt Jolana Bartova Jan Bures | 2010 | World Journal of Gastroenterology2010，16，19： | 18 |
| 3 | Blood pressure and stature in Helicobacter pylori positive and negative persons显示文摘To evaluate vital signs and body indices in Helicobacter pylori(H.pylori)positive and negative persons.A total of 22 centres entered the study.They were spread over the whole country,corresponding well to the geographical distribution of the Czech population.A total of 1818 subjects(aged 5-98 years)took part in the study,randomly selected out of 38147 subjects.H.pylori infection was investigated by means of a 13Curea breath test.Data on height,weight,systolic and diastolic blood pressure and heart rate were collected at the clinics of general practitioners.The overall prevalence of H.pylori infection was 30.4%(402/1321)in adults(≥18 year-old)and 5.2%(26/497)in children and adolescents(≤17 year-old).Once adjusted for age and gender,only a difference in body mass index remained statistically significant with H.pylori positive adults showing an increase of 0.6 kg/m2 in body mass index.Once adjusted for age and gender,we found a difference in height between H.pylori positive and H.pylori negative children and adolescents.On further adjustment for place of residence,this difference became statistically significant,with H.pylori positive children and adolescents being on average 3.5 cm shorter.H.pylori positive adults were significantly older compared to H.pylori negative subjects.Once adjusted for age and gender,H.pylori infection had no impact on body weight,body mass index and vital signs either in adults or children and adolescents.Chronic H.pylori infection appeared to be associated with short stature in children.H.pylori infection did not influence blood pressure,body weight and body mass index either in adults or children and adolescents. | Marcela Kopacova Ilona Koupil Bohumil Seifert Miluska Skodova Fendrichova Jana Spirkova Viktor Vorisek Stanislav Rejchrt Tomas Douda Ilja Tacheci Jan Bures | 2014 | World Journal of Gastroenterology2014，20，19： | 9 |
| 4 | Ephrin-B2 is differentially expressed in the intestinal epithelium in Crohn's disease and contributes to accelerated epithelial wound healing in vitro显示文摘AIM: Eph receptor tyrosine kinases and their membrane bound receptor-like ligands, the ephrins, represent a bi-directional cell-cell contact signaling system that directs epithelial movements in development. The meaning of this system in the adult human gut is unknown. We investigated the Eph/ephrin mRNA expression in the intestinal epithelium of healthy controls and patients with inflammatory bowel disease (IBD).METHODS: mRNA expression profiles of all Eph/ephrin family members in normal small intestine and colon were established by real-time RT-PCR. In addition, differential expression in IBD was investigated by cDNA array technology, and validated by both real-time RT-PCR and immunohistochemistry. Potential effects of enhanced EphB/ephrin-B signaling were analyzed in an in vitro IEC-6 cell scratch wound model.RESULTS: Human adult intestinal mucosa exhibits a complex pattern of Eph receptors and ephrins. Beside the known prominent co-expression of EphA2 and ephrinA1,we found abundantly co-expressed EphB2 and ephrin-B1/2.Interestingly, cDNA array data, validated by real-time PCR and immunohistochemistry, showed upregulation of ephrin-B2 in both perilesional and lesional intestinal epithelial cells of IBD patients, suggesting a role in epithelial homeostasis. Stimulation of ephrin-B signaling in ephrinB1/2 expressing rat IEC-6-cells with recombinant EphB1Fc resulted in a significant dose-dependent acceleration of wound closure. Furthermore, fluorescence microscopy showed that EphB1-Fc induced coordinated migration of wound edge cells is associated with enhanced formation of lamellipodial protrusions into the wound, increased actin stress fiber assembly and production of laminin at the wound edge.CONCLUSION: EphB/ephrin-B signaling might represent a novel protective mechanism that promotes intestinal epithelial wound healing, with potential impact on epithelial restitution in IBD. | Christian Hafner Stefanie Meyer Thomas Langmann Gerd Schmitz Frauke Bataille Ilja Hagen Bernd Becker Alexander Roesch Gerhard Rogler Michael Landthaler Thomas Vogt | 2005 | World Journal of Gastroenterology2005，11，26： | 9 |
| 5 | Significant decrease in prevalence ofHelicobacter pylori in the Czech Republic显示文摘AIM:To study possible decrease in prevalence of Helicobacter pylori(H.pylori) infection in the Czech Republic within a 10-year period.METHODS:A total of 22 centres entered the study.The catchment areas of these centres covered cities and towns with more than 20 000 inhabitants,smaller towns(≤ 20 000 inhabitants) with surrounding villages and rural areas,and were spread over the whole country,corresponding well to the geographical distribution of the Czech population.A total of 1 837 subjects(aged 5-98 years) took part in the study,randomly selected out of 38 147 people from the general population.H.pylori infection was investigated by means of a 13 C-urea breath test.Breath samples in duplicates were analysed using isotope ratio mass spectrometry.The cut-off point was 3.5.Social and demographic characteristics were based on data from self-completed questionnaires.RESULTS:The overall prevalence of H.pylori infection was 23.5%(430/1826),and 4.8%(20/420) in children aged 15 or less.There was no statistically significant difference in prevalence between males(24.3%;208/857) and females(22.9%,222/969,P = 0.494).H.pylori infection was strongly associated with higher age,among subjects aged 55+ years,prevalence of H.pylori infection was 39.8%(252/633,P < 0.001).The highest prevalence of H.pylori infection was found among persons aged 55-64 years(43.9%,97/221) and 75+ years(37.9%,58/153).Among study subjects aged 15+ years,prevalence of H.pylori infection was significantly increased in those with lowest education(odds risk 3.19,95% CI 1.87-5.47).Compared to never married(14.1%),the prevalence of H.pylori infection was statistically significantly higher among married(35.4%,246/694,P < 0.001),divorced(36.8%,49/133,P < 0.001) and widowed study subjects(40.2%,45/112,P < 0.001),both in minimally and fully adjusted analysis.There was no significant difference in the prevalence of H.pylori infection between married and widowed subjects(35.4%,246/694 vs 40.2%,45/112,P = 0.389).There was little variation in smoking prevalence across categories of smoking and there was no evidence of an increased risk ofH.pylori infection among current or past smokers in our data(odds risk 1.04 with 95% CI 0.78-1.40 for current smokers;odds ratio 0.83 with 95% CI 0.60-1.16 for former smokers).The current prevalence of H.pylori in 2011 was significantly lower compared to the prevalence reported from identical geographical areas in 2001(23.5%vs 41.7%,P < 0.001).CONCLUSION:The overall prevalence of H.pylori infection in the general population has fallen substantially in the Czech Republic over the past 10 years. | Jan Bure Marcela Kopáová Ilona Koupil Bohumil Seifert Miluka kodová Fendrichová Jana pirková Viktor Voíek Stanislav Rejchrt TomáDouda Norbert Král Ilja Tachecí | 2012 | World Journal of Gastroenterology2012，18，32： | 8 |
| 6 | Mechanical and Frictional Properties of the Elytra of Five Species of Beetles显示文摘 | Min Yu Ilja Hermann Zhendong Dai Norm Gitis | 2013 | Journal of Bionic Engineering2013，10，1： | 3 |
| 7 | Comparison of drug abuse in Germany and China显示文摘药滥用在德国和中国有长,而且不同的历史。鸦片战争大部分在第 19 世纪影响了中国的历史;然而,中国曾经从 1950 年代作为一个没有药的国家被认出 3 十年到 1980 年代。自从 re-emerging,药滥用在 1980 年代末在中国作为一个国家问题快速传播了。登记吸毒者的数字增加了从 70 000 在 1990 到超过 100 万在 2005 底。在过去的十年,不正当的药交通国王和生产在中国打扫了大多数省,并且药滥用为滥用者和社区引起了许多问题。一个主要药相关的问题是 HIV 的传播,它在中国引起了主要社会、经济的损坏。德国,最大的发达欧洲国家,也面对这药和嗜好问题。德国有大约 150 000 个海洛因瘾君子,自从 1980 年代中, HIV/AIDS 为成为了严肃的威胁。控制药问题,德国政府在 2003 在药和 Addictionq 上采用了合同计划;中国中央政府在 2005 在反药运动同意了一条类似的规定。德国在减少药相关的伤害有经验。一种镇痛剂维护处理(MMT ) 节目竞选了超过 20 年,公众瘾君子变得更容忍。在 2003,中国为控制 HIV/AIDS 的传播开始了 MMT 节目。中国从发达国家学习在它的反药运动获得成功是必要的。在这评论,我们将温习在在德国和中国之间的药滥用的差别和类似。差别与历史,人口和经济有关,药政策上下文,药法律, HIV/hepatitis C 病毒感染, MMT 节目等等。这 2 个国家与不同历史有药滥用问题并且当前使用不同途径处理不正当的药出售和使用。为不正当的药冒犯的法律惩罚关于罪行的特别类型的严重反映这 2 个国家的社会差别。MMT 节目的特征可以也在这 2 个国家影响药滥用的模式,中国应该在欧洲,美国,和澳大利亚基于成功的模型改进 MMT 节目。我们推荐在德国和中国之间的更多的对话和合作。 | Ingo Ilja MICHELS Yu-xia FANG Dong ZHAO Li-yan ZHAO Lin LU | 2007 | Acta Pharmacologica Sinica2007，28，10： | 2 |
| 8 | Ephrin-B reverse signaling induces expression of wound healing associated genes in IEC-6 intestinal epithelial cells显示文摘AIM: Eph receptors and ephrin ligands play a pivotal role in development and tissue maintenance. Since previous data have indicated an involvement of ephrin-B2 in epithelial healing, we investigated the gene expression and downstream signaling pathways induced by ephrin-B mediated cell-cell signaling in intestinal epithelial cells.METHODS: Upon stimulation of ephrin-B pathways in IFC-6 cells with recombinant rat EphB1-Fc, gene expression was analyzed by Affymetrix(R) rat genome 230 high density arrays at different time points. Differentially expressed genes were confirmed by real-time RT-PCR. In addition, MAP kinase pathways and focal adhesion kinase (FAK) activation downstream of ephrin-B were investigated by immunoblotting and fluorescence microscopy.RESULTS: Stimulation of the ephrin-B reverse signaling pathway in IEC-6 cells induces predominant expression of genes known to be involved into wound healing/cell migration, antiapoptotic pathways, host defense and inflammation. Cox-2, c-Fos, Egr-1, Egr-2, and MCP-1 were found among the most significantly regulated genes.Furthermore, we show that the expression of repairrelated genes is also accompanied by activation of the ERK1/2 MAP kinase pathway and FAK, two key regulators of epithelial restitution.CONCLUSION: Stimulation of the ephrin-B reverse signaling pathway induces a phenotype characterized by upregulation of repair-related genes, which may partially be mediated by ERK1/2 pathways. | Christian Hafner Stefanie Meyer Ilja Hagen Bernd Becker Alexander Roesch Michael Landthaler Thomas Vogt | 2005 | World Journal of Gastroenterology2005，11，29： | 2 |
| 9 | 德国的阿片类依赖替代治疗(英文)显示文摘经过漫长而激烈的争论,德国于1987年首次引进了美沙酮维持治疗。最初,由于入治标准严格,接受治疗的人数很少,但自1990年后接受治疗的人数迅速上升,到2005年底已有61 000人。在德国每位全科医生只要完成了成瘾医学的培训都允许为阿片类成瘾病人开具替代治疗药物。目前德国有2700个全科医生在为阿片类药物成瘾病人开具处方。每位参加维持治疗的病人需接受社会心理治疗。研究结果和实践经验表明,病人从美沙酮维持治疗中获得了实质性的好处,他们的身心健康得到了改善。美沙酮维持治疗的留治率高(65% -85%),对HIV和肝炎的评估和坚持治疗十分重要;在促进病人回归社会方面也是极其重要的因素;在降低药物相关伤害方面如:减少共患疾病、死亡和预防感染性疾病具有重要的作用。有10%的人在长期的治疗过程中戒掉了毒品。虽然丁丙诺啡正在显示其重要性,但是美沙酮仍是主要的替代药物。在农村,参加美沙酮维持治疗仍是难题。虽然一致认为工作是治疗的正性因素,但对病人来说就业机会很少。德国监狱的替代治疗采用不同的准入和治疗模式。准入治疗不协调,参加治疗的人数很少。无论如何,在德国替代治疗在为药物使用者提供的卫生医疗系统中发挥了重要作用。 | Ingo Ilja MICHELS Heino STVER Ralf GERLACH | 2007 | 中国药物依赖性杂志2007，16，3： | 2 |
| 10 | Low Temperature Processing of Hybrid Nanoparticulate Indium Tin Oxide(ITO)Pol-ymer Layers and Application in Large Scale Lighting Devices显示文摘 | Ilja Maksimenko Peter Wellmann | 2011 | Thin Solid Films2011，，519： | 1 |
| 11 | Catalytic syngas production from greenhouse gasses: performance comparison of Ru-Al203 and Rh-CeO2 cata- lysts 显示文摘 | Petar Djinovic Ilja Gasan Osojnik cmivec Jurka Batista | 2011 | Chemical Engineering and Processing: Process Intensification2011，50，10： | 1 |
| 12 | Secondary caries-like lesions at fissure sealings with Xeno Ⅲ and Delton-an in vitro study显示文摘 | Rainer Seemann Ilja Kluck Mozhgan Bizhang | 2005 | Journal of Dentistry2005，33，5： | 1 |
| 13 | SIRT1 stimulation by polyphenols is affected by their stability and metabolism显示文摘 | Vincent C.J. de Boer Marcus C. de Goffau Ilja C.W. Arts Peter C.H. Hollman Jaap Keijer | 2006 | Mechanisms of Ageing and Development2006，，7： | 1 |
| 14 | Evidence of DensityDependent Dephasing in Interferometric Four-Wave-Mixing Experiments on Heavy-Hole Excitons in ZnSe Quantum Wells显示文摘 | Georg B H Tammo T Ilja R | 2002 | Physica B2002，314，： | 1 |
| 15 | Root associated organisms modify the effectiveness of chemically induced resistance in barley显示文摘 | Ilja Sonnemann Nele Mika Streicher1 Volkmar Wolters1 | 2005 | Soil Biology & Biochemistry2005，，37： | 1 |
| 16 | Configurational bias Monte Carlo: a new sampling scheme for flexible chains显示文摘 | Jorn Ilja Siepmann Daan Frenkel | 1992 | Molecular Physics1992，，1： | 1 |
| 17 | Helmholtz resonator withextended neck 显示文摘 | Ahmet Selamet Iljae Lee | 2003 | Journal of the Acoustical Society of America2003，113，： | 1 |
| 18 | A framework for adap-tive content delivery in heterogeneous network environments 显示文摘 | Wei-Ying Ma Ilja Bedner Grace Chang | 2005 | Hewlett-Packard Laboratories2005，，： | 1 |
| 19 | Complex phytohormone respons- es during the cold acclimation of two wheat cuhivars differing in cold tolerance, winter Samanta and spring Sandra显示文摘 | Klara K Ilja Tom P Pavel V | 2012 | Journal of Plant Physiology2012，169，6： | 1 |
| 20 | Complex phytohormone responses during the cold acclimation of two wheat cultivars differing in cold tolerance, winter Samanta and spring Sandra显示文摘 | Klára Kosová Ilja Tom Prá?il Pavel Vítámvás Petre Dobrev Václav Motyka Kristyna Floková Ond?ej Novák Veronika Ture?ková Jakub Rol?ik Bed?ich Pe?ek Alena Trávni?ková Alena Gaudinová Gabor Galiba Tibor Janda Eva Vlasáková Pavla Prá?ilová Radomíra Vanková | | Journal of Plant Physiology0，，： | 1 |
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