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| 1 | Resected tumor seeding in stomach wall due to endoscopic ultrasonography-guided fine needle aspiration of pancreatic adenocarcinoma显示文摘Endoscopic ultrasonography-guided fine needle aspiration(EUS-FNA) is a useful and relatively safe tool for the diagnosis and staging of pancreatic cancer. However, there have recently been several reports of tumor seeding after EUS-FNA of adenocarcinomas. A 78-year-old man was admitted to our hospital due to upper gastric pain. Examinations revealed a 20 mm mass in the pancreatic body, for which EUS-FNA was performed. The cytology of the lesion was adenocarcinoma, and the stage of the cancer was T3N0M0. The patient underwent surgery with curative intent, followed by adjuvant chemotherapy with S-1. An enlarging gastric submucosal tumor was found on gastroscopy at 28 mo after surgery accompanied by a rising level of CA19-9. Biopsy result was adenocarcinoma, consistent with a pancreatic primary tumor. Tumor seeding after EUS-FNA was strongly suspected. The patient underwent surgical resection of the gastric tumor with curative intent. The pathological result of the resected gastric specimen was adenocarcinoma with a perfectly matched mucin special stain result with the previously resected pancreatic cancer. This is the first case report of tumor seeding after EUS-FNA which was surgically resected and inspected pathologically. | Akiko Tomonari Akio Katanuma Tomoaki Matsumori Hajime Yamazaki Itsuki Sano Ryuki Minami Manabu Sen-yo Satoshi Ikarashi Toshifumi Kin Kei Yane Kuniyuki Takahashi Toshiya Shinohara Hiroyuki Maguchi | 2015 | World Journal of Gastroenterology2015，21，27： | 3 |
| 2 | Proposed criteria to differentiate heterogeneous eosinophilic gastrointestinal disorders of the esophagus, including eosinophilic esophageal myositis显示文摘AIM To define clinical criteria to differentiate eosinophilic gastrointestinal disorder(Eo GD) in the esophagus. METHODS Our criteria were defined based on the analyses of the clinical presentation of eosinophilic esophagitis(Eo E), subepithelial eosinophilic esophagitis(s Eo E) and eosinophilic esophageal myositis(Eo EM), identified by endoscopy, manometry and serum immunoglobulin E levels(s-Ig E), in combination with histological and polymerase chain reaction analyses on esophageal tissue samples.RESULTS In five patients with Eo E, endoscopy revealed longitudinal furrows and white plaques in all, and fixed rings in two. In one patient with s Eo E and four with Eo EM, endoscopy showed luminal compression only. Using manometry, failed peristalsis was observed in patients with Eo E and s Eo E with some variation, while Eo EM was associated with hypercontractile or hypertensive peristalsis, with elevated s-Ig E. Histology revealed the following eosinophils per high-power field values. Eo E = 41.4 ± 7.9 in the epithelium and 2.3 ± 1.5 in the subepithelium; s Eo E = 3 in the epithelium and 35 in the subepithelium(conventional biopsy); Eo EM = none in the epithelium, 10.7 ± 11.7 in the subepithelium(conventional biopsy or endoscopic mucosal resection) and 46.8 ± 16.5 in the muscularis propria(peroral esophageal muscle biopsy). Presence of dilated epithelial intercellular space and downward papillae elongation were specific to Eo E. Eotaxin-3, IL-5 and IL-13 were overexpressed in Eo E.CONCLUSION Based on clinical and histological data, we identified criteria, which differentiated between Eo E, s Eo E and Eo EM, and reflected a different pathogenesis between these esophageal Eo GDs. | Hiroki Sato Nao Nakajima Kazuya Takahashi Go Hasegawa Ken-ichi Mizuno Satoru Hashimoto Satoshi Ikarashi Kazunao Hayashi Yutaka Honda Junji Yokoyama Yuichi Sato Shuji Terai | 2017 | World Journal of Gastroenterology2017，23，13： | 2 |
| 3 | Preparation of the bulk Fe-Al-Ga-P-C-B-Si glassy alloys in a ringed form by copper mold casting显示文摘 | Ikarashi K Mizushima T | 2001 | Materials Science and Engineering2001，，： | 1 |
| 4 | Partial agonis?tic effect of yokukansan on human recombinant serotonin 1 A receptors expressed in the membranes of Chinese ham?ster ovary cells 显示文摘 | Terawaki K Ikarashi Y Sekiguchi K | 2010 | J Ethnopharmacol2010，127，2： | 1 |
| 5 | Local lattice strain measurements in semiconductor devices by using convergent-beam electron diffraction显示文摘 | Toda A Ikarashi N Ono H | | 0，，： | 1 |
| 6 | NGF delays rather than prevents the cholinergic terminal damage and delayed neuronal death in the hippocampus after ischermia显示文摘 | Ishimaru H Takahashi A Ikarashi Y | 1998 | Brain Res1998，789，： | 1 |
| 7 | Determination of p-phenylenediamine and related antioxidants in rubber boots by high performance liquid ehromatography显示文摘 | Ikarashi Y Kaniwa M | 2000 | Journal of Health Science2000，46，6： | 1 |
| 8 | Risk factors for severe coronary artery disease and case control study of patients who have undergone coronary artery bypass grafting显示文摘 | Kosuge K Sasaki H Ikarashi T | | 0，，： | 1 |
| 9 | Anomolous ring-shaped dis- tribution of oxygen precipitates in a Czochralsk-i grown sili- con crystal 显示文摘 | Ono H Ikarashi T Kimura S | 1995 | J Appl Phys1995，78，： | 1 |
| 10 | Risk factors for severe coronary artery disease casecontrol study of patients who have undergone coronary artery bypass grafting显示文摘 | Kosuge K Sasaki H Ikarashi T | 2006 | J Atheroscler Thromb2006，13，1： | 1 |
| 11 | Development of analytical method for determination of 1,4-dioxane in cleansing products 显示文摘 | Tahara M Obama T Ikarashi Y | 2013 | International Journal of Cosmetic Science2013，，35： | 1 |
| 12 | Yokukansan, kampo medicine, protects against glutamate cytotoxicity due to oxidative stress in PC12 cell显示文摘 | Kawakami Z Kanno H Ikarashi Y | 2011 | J Ethnopharmacol2011，134，1： | 1 |
| 13 | Is extended lymph node dissection necessary for gastric cancer in elderly patients?显示文摘 | Eguchi T Takahashi Y Ikarashi M | 2000 | EurJ Surg2000，166，12： | 1 |
| 14 | Hepatic early inflammation induces downregulation of hepatic cytochrome P450 expression and metabolic activity in the dextran sulfate sodium induced murine colitis显示文摘 | Kusunoki Y Ikarashi N Hayakawa Y | 2014 | Eur J Pharm Sci2014，54，： | 1 |
| 15 | The bedtime administration of doxazosin controis morning hypertension and albuminuria in patients with type-2 diabetes: evaluation using home-based blood pressure measurements 显示文摘 | Kamoi K Ikarashi T | 2005 | Clin Exp Hypertens2005，27，4： | 1 |
| 16 | Intestinal flora induces the expression of Cyp3a in the mouse liver 显示文摘 | Toda T Saito N Ikarashi N | 2009 | Xenobiotica2009，39，4： | 1 |
| 17 | Comparative studies by cell culture and in vivo implantation test on the toxicy of natural latex materials显示文摘 | Ikarashi Y | 1992 | J biomed mater res1992，26，3： | 1 |
| 18 | Studies on the tumor-promoting activities of additives in biomaterials: inhibition of metabolic cooperation by additives such as pigments and phenolic antioxidants显示文摘 | Tsuchiya T Ikarashi Y Nakamura A | 1995 | J Long Term Eff Med Implants1995，，5： | 1 |
| 19 | Endoscopic ultrasound-guided fine-needle aspiration for diagnosing a rare extraluminal duodenal gastrointestinal tumor显示文摘Duodenal gastrointestinal stromal tumors(GISTs) are extremely rare disease entities, and the extraluminal type is difficult to diagnose. These tumors have been misdiagnosed as pancreatic tumors; hence, pancreaticoduodenectomy has been performed, although partial duodenectomy can be performed if accurately diagnosed. Developing a diagnostic methodology including endoscopic ultrasonography(EUS) and fine-needle aspiration(FNA) has allowed us to diagnose the tumor directly through the duodenum. Here, we present a case of a 50-year-old woman with a 27-mm diameter tumor in the pancreatic uncus on computed tomography scan. EUS showed a well-defined hypoechoic mass in the pancreatic uncus that connected to the duodenal proper muscular layer and was followed by endoscopic ultrasoundguided fine-needle aspiration(EUS-FNA). Histological examination showed spindle-shaped tumor cells positively stained for c-kit. Based on these findings, the tumor was finally diagnosed as a duodenal GIST of the extraluminal type, and the patient underwent successful mass resection with partial resection of the duodenum. This case suggests that EUS and EUS-FNA are effective for diagnosing the extraluminal type of duodenal GISTs, which is difficult to differentiate from pancreatic head tumor, and for performing the correct surgical procedure. | Kazunao Hayashi Kenya Kamimura Kazunori Hosaka Satoshi Ikarashi Junji Kohisa Kazuya Takahashi Kentaro Tominaga Kenichi Mizuno Satoru Hashimoto Junji Yokoyama Satoshi Yamagiwa Kazuyasu Takizawa Toshifumi Wakai Hajime Umezu Shuji Terai | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，12： | 1 |
| 20 | Risk factors for severe coronary artery disease-a case-consul study of patients who have undergone corongary artery bypass grafting显示文摘 | Kosuge K Sasaki H Ikarashi T | 2006 | J Atheroscler Thromb2006，13，1： | 1 |
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