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| 1 | Contrast-enhanced ultrasound Liver Imaging Reporting and Data System:Lights and shadows in hepatocellular carcinoma and cholangiocellular carcinoma diagnosis显示文摘BACKGROUND Contrast-enhanced ultrasound(CEUS)is considered a secondary examination compared to computed tomography(CT)and magnetic resonance imaging(MRI)in the diagnosis of hepatocellular carcinoma(HCC),due to the risk of misdiagnosing intrahepatic cholangiocarcinoma(ICC).The introduction of CEUS Liver Imaging Reporting and Data System(CEUS LI-RADS)might overcome this limitation.Even though data from the literature seems promising,its reliability in real-life context has not been well-established yet.AIM To test the accuracy of CEUS LI-RADS for correctly diagnosing HCC and ICC in cirrhosis.METHODS CEUS LI-RADS class was retrospectively assigned to 511 nodules identified in 269 patients suffering from liver cirrhosis.The diagnostic standard for all nodules was either biopsy(102 nodules)or CT/MRI(409 nodules).Common diagnostic accuracy indexes such as sensitivity,specificity,positive predictive value(PPV),and negative predictive value(NPV)were assessed for the following associations:CEUS LR-5 and HCC;CEUS LR-4 and 5 merged class and HCC;CEUS LR-M and ICC;and CEUS LR-3 and malignancy.The frequency of malignant lesions in CEUS LR-3 subgroups with different CEUS patterns was also determined.Inter-rater agreement for CEUS LI-RADS class assignment and for major CEUS pattern identification was evaluated.RESULTS CEUS LR-5 predicted HCC with a 67.6%sensitivity,97.7%specificity,and 99.3%PPV(P<0.001).The merging of LR-4 and 5 offered an improved 93.9%sensitivity in HCC diagnosis with a 94.3%specificity and 98.8%PPV(P<0.001).CEUS LR-M predicted ICC with a 91.3%sensitivity,96.7%specificity,and 99.6%NPV(P<0.001).CEUS LR-3 predominantly included benign lesions(only 28.8%of malignancies).In this class,the hypo-hypo pattern showed a much higher rate of malignant lesions(73.3%)than the iso-iso pattern(2.6%).Inter-rater agreement between internal raters for CEUS-LR class assignment was almost perfect(n=511,k=0.94,P<0.001),while the agreement among raters from separate centres was substantial(n=50,k=0.67,P<0.001).Agreement was stronger for arterial phase hyperenhancement(internal k=0.86,P<2.7×10-214;external k=0.8,P<0.001)than washout(internal k=0.79,P<1.6×10-202;external k=0.71,P<0.001).CONCLUSION CEUS LI-RADS is effective but can be improved by merging LR-4 and 5 to diagnose HCC and by splitting LR-3 into two subgroups to differentiate iso-iso nodules from other patterns. | Gianpaolo Vidili Marco Arru Giuliana Solinas Diego Francesco Calvisi Pierluigi Meloni Assunta Sauchella Davide Turilli Claudio Fabio Antonio Cossu Giordano Madeddu Sergio Babudieri Maria Assunta Zocco Giovanni Iannetti Enza Di Lembo Alessandro Palmerio Delitala Roberto Manetti | 2022 | World Journal of Gastroenterology2022，28，27： | 3 |
| 2 | A CFD Study on the Mechanisms Which Cause Cavitation in Positive Displacement Reciprocating Pumps显示文摘A transient multiphase CFD (computational fluid dynamics) model was set up to investigate the main causes which lead to cavitation in PD (positive displacement) reciprocating pumps. Many authors agree on distinguishing two different types of cavitation affecting PD pumps: flow induced cavitation and cavitation due to expansion. The flow induced cavitation affects the zones of high fluid velocity and consequent low static pressure e.g. the valve-seat volume gap while the cavitation due to expansion can be detected in zones where the decompression effects are important e.g. in the vicinity of the plunger. This second factor is a distinctive feature of PD pumps since other devices such as centrifugal pumps are only affected by the flow induced type. Unlike what has been published in the technical literature to date, where analysis of positive displacement pumps are based exclusively on experimental or analytic methods, the work presented in this paper is based entirely on a CFD approach, it discusses the appearance and the dynamics of these two phenomena throughout an entire pumping cycle pointing out the potential of CFD techniques in studying the causes of cavitation and assessing the consequent loss of performance in positive displacement pumps. | Aldo Iannetti Matthew T. Stickland William M. Dempster | 2015 | Journal of Hydraulic Engineering2015，1，1： | 2 |
| 3 | Representation of different trigeminal division within the primary and secondary human somatosensory cortex显示文摘 | Porro CA Pantano P | 2003 | Neuroimage2003，19，3： | 1 |
| 4 | Brainstem reflex circuits revisited显示文摘 | Cruccu G Iannetti GD Marx J | 2005 | Brain2005，128，2： | 1 |
| 5 | Functional responses in the human spinal cord during willed motor actions: evidence for side-and rate-dependent activity 显示文摘 | Maieron M Iannetti GD Bodurka J | 2007 | J Neurosci2007，27，15： | 1 |
| 6 | Le Fort m advancement with and without ostcogenesis distraction显示文摘 | Iannetti G Fadda T Agrillo A | 2006 | J CraniofacSurg2006，17，： | 1 |
| 7 | A8 Nociceptor Response to Laser Stimuli: Selective Effect of Stimulus Duration on Skin Temperature, Brain Potentials and Pain Perception显示文摘 | IANNETTI G D LEANDRI M TRUINI A | 2004 | Clin Neurophysiol2004，115，： | 1 |
| 8 | Efficacy and safety of topiramate in refraclory epilepsy of childhood: long-term fol- low-up study 显示文摘 | Grosso S Franzoni E Iannetti P | 2005 | J Child Neurol2005，20，11： | 1 |
| 9 | The neutrophil ge- latinase-associated lipocalin (NGAL), a NF-kappaB-regulated gene, is a survival factor for thyroid neoplastic cells 显示文摘 | Iannetti A Pacifico F Aequaviva R | 2008 | Proe Natl Acad Sei USA2008，105，14： | 1 |
| 10 | Le Fort Ⅲ external midface distraction:surgical outcomes and skeletal stability显示文摘 | Iannetti G Ramieri V Pagnoni M Fadda MT Cascone P | | 0，，： | 1 |
| 11 | Efficacy and safety of topiramate in refractory epilepsy of childhood: long-term follow-up study显示文摘 | Grosso S Franzoni E Iannetti P | 2005 | J Child Neurol2005，20，11： | 1 |
| 12 | Condlar hyperplasia:cephalmetric study,treatment planning,and surgical correction (our experience)显示文摘 | Iannetti G Cascone P Belli E | 1989 | Oral Surg Oral Med Oral Pathol1989，68，6： | 1 |
| 13 | Representation of different trigeminal divisions within the primary and secondary human somatosensory cortex显示文摘 | Iannetti GD Porto CA Pantano P | 2003 | Neuroimage2003，19，3： | 1 |
| 14 | Calcium-channel Blocker Vempamil Administration in Prolonged and Refractory Status Epilepticus 显示文摘 | Iannetti P Spalice A Parisi P | 2005 | Epilepsia (S0013 - 9580)2005，46，6： | 1 |
| 15 | Optical coherence tomography for classification and clinical evaluation of macular edema in patients with uveitis显示文摘 | Iannetti L Accorinti M Liverani M | 2008 | Ocul Immunol Inflamm2008，16，4： | 1 |
| 16 | Central serous chorioretinop- athy as a presenting symptom of endogenous Cushing syndrome: a case report显示文摘 | Iannetti L Spinucci G Pesci FR | 2011 | Eur J Ophthalmol2011，21，5： | 1 |
| 17 | From the neuromatrix to the pain matrix(and back)显示文摘 | Iannetti GD Mouraux A | 2010 | Exp Brain Res2010，205，1： | 1 |
| 18 | Critical analysis of phase II and III randomised control trials ( RCTs ) evaluating efficacy and tolerability of a β3‐adrenoceptor agonist ( M irabegron) for overactive bladder ( OAB )显示文摘 | Marta Rossanese Giacomo Novara Ben Challacombe Alessandro Iannetti Prokar Dasgupta Vincenzo Ficarra | 2015 | BJU Int2015，，1： | 1 |
| 19 | Brainstem reflex circuits revisited显示文摘 | Cruccu G Iannetti G D Marx J J | 2005 | Brain2005，128，2： | 1 |
| 20 | Calcium-channel blocker verapamil administration in prolonged and refractory status epilepticus显示文摘 | IANNETTI P SPALICE A PARISI P | 2005 | Epilepsia2005，46，6： | 1 |
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