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	题名	作者	年代	出处	被引量
1	Specific and cross-reactive immune response against Mycobacterium tuberculosis antigens in mice immunized with proteoliposomes from Mycobacterium bovis BCG显示文摘Objective: To characterize the immunogenicity and the induction of cross-reactive responses against Mycobacterium tuberculosis(M. tuberculosis) of a proteoliposome(PL)from Mycobacterium bovis Bacillus Calmette–Guerin(BCG) with and without alum hydroxide(AL) as adjuvant(PLBCG-AL and PLBCG, respectively) in BALB/c mice.Methods: BALB/c mice were inoculated with phosphate buffer solution, BCG, PLBCG and PLBCG-AL. The humoral immunogenicity was determined by ELISA [immunoglobulin G(Ig G), Ig G1 and Ig G2a] and the cellular immunogenicity was evaluated in vivo by delayed type hypersensitivity. The humoral cross-reactive response against M. tuberculosis was determined by Western blot.Results: Sera from animals immunized with PLBCG-AL and PLBCG showed significant increase in specific total Ig G and Ig G1 antibodies and the presence of cross-reactive antibodies against M. tuberculosis antigens, which were more intense with the use of alum as adjuvant. Mice immunized with PLBCG and PLBCG-AL also showed a specific cellular response in vivo.Conclusions: The cellular and humoral immunogenicity of PLBCG and the capacity to induce cross-reactive responses against M. tuberculosis is in agreement with the protective capacity previously demonstrated by this vaccine candidate and supports the continuation of its evaluation in further stages.	Nadine Alvarez DaymíSerpa Ramlah Kadir Yanely Tirado Reinier Borrero Sonsire Fernández Rubén Cabrera Yolanda Valdes Caridad Zayas Reinaldo Acevedo Luis Izquierdo María Elena Sarmiento Mohd-Nor Norazmi JoséLuis Pérez Armando Acosta	2017	Asian Pacific Journal of Tropical Biomedicine2017，7，3：	3
2	Modeling PSA problems- I : The stimulus-driven theory of probabilistic dynamics 显示文摘	LABEAU P E IZQUIERDO J M	2005	Nuclear Science and Engineering2005，，150：	1
3	Selection of autochthonous Oenococcus oeni strains according to their oenological properties and vinification results显示文摘	RUIZ P IZQUIERDO M P SESEIqA S	2010	International Journal of Food Microbiology2010，137，23：	1
4	Characterization of an antithrombotic peptide from kappa-casein in new- born plasma after milk ingestion显示文摘	Chabance B Jolles P Izquierdo C	1995	Brit J Nutr1995，73，：	1
5	Formation and stability of nano-emusions preqared using the phase inversion temperature method显示文摘	P Izquierdo J Esquena T F Tadros	2002	Langmuir2002，18，：	1
6	Modeling of copper fixed-bed biosorption from wastewater by Posidonia oceanica显示文摘	Izquierdo M Gabaldon C Marzal P Alvarez-Homos F J	2010	Bioresource Technology2010，101，2：	1
7	Effect of sperm capacitation and fertilization media on IVF and early embryo development of pre-pubertal goat oocytes显示文摘	Izquierdo D Villamediana P Palomo M J	1998	Theriogenology1998，49，：	1
8	Formation and stability of nano-emulsions prepared using the phase inversion temperature method 显示文摘	Izquierdo P Esquena J Tadros T F	2002	Langmuir2002，18，1：	1
9	Impact of magnetic resonance imaging on decision making for thoracolumbar traumatic fracture diagnosis and treatment显示文摘	Pizones J Izquierdo E Alvarez P	2011	Eur Spine J2011，20，3：	1
10	Nano - emulsions 显示文摘	SOLANS C IZQUIERDO P NOLLA J	2005	Current Opinion in Colloid & Interface Science2005，10，：	1
11	Formation and stability of nano-emulsions显示文摘	Izquierdo P Esquena J	2004	Advances in Colloid and Interface Science2004，，5：	1
12	Tricistronic and tetracistronic ret-roviral vectors for gene transfer显示文摘	De Felipe P Izquierdo M	2000	Hum Gene Ther2000，11，13：	1
13	The parathyroid hormnere lated protein system and diabetic nephropathy outcome in strep tozotocin-induced diabetes显示文摘	Izquierdo A Lepez-Luna P Ortega A		0，，：	1
14	The influence of surfactant mixing ratio on nano -emulsion formation by the pit method 显示文摘	IZQUIERDO P FENG J ESQUENA J	2005	Journal of Colloid and Interface Science2005，285，：	1
15	Formation and stability of nano-emulsions显示文摘	Tadros T Izquierdo P Esquena J	2004	Adv Colloid Interface Sci2004，，：	1
16	Selection of autochthonous Oenococcus oeni strains according to their oenological properties and vinification results显示文摘	RUIZ P IZQUIERDO P M SESE(N)A S		0，，2：	1
17	Nano-emulsions 显示文摘	SOLANS C IZQUIERDO P NOLLA J	2005	Current Opinion in Colloid Interface Sci-ence2005，10，：	1
18	Formation and stability of nano - emulsions 显示文摘	TADROS T IZQUIERDO P ESQUENA J	2004	Advances in Colloid and Interface Science2004，，：	1
19	Nano - emulsions 显示文摘	SOLANS C IZQUIERDO P NOLLA J	2005	Colloid Interface Sci2005，10，：	1
20	Screening for glycosidase activities of lactic acid bacteria as a biotechnological tool in oenology显示文摘	P(E)REZ-MART(I)N N F SESENA S IZQUIERDO P M		0，，04：	1

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