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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Z-BUS Loss Allocation显示文摘 | Conejo J Gliana D Ivana Kockar | 2001 | IEEE Trans on Power Systems2001，16，1： | 1 |
| 3 | Adipose tissue resistin levels in patients with anorexia nervosa 显示文摘 | Ivana D Marie K Jaroslava D | 2006 | Nutrition2006，22，10： | 1 |
| 4 | Mesenchymal Stem/Stromal Cells: A New ’’Cells as Drugs’’ Paradigm. Efficacy and Critical Aspects in Cell Therapy显示文摘 | Laura de Girolamo Enrico Lucarelli Giulio Alessandri Maria Antonietta Avanzini Maria Ester Bernardo Ettore Biagi Anna Teresa Brini Giovanna D’Amico Franca Fagioli Ivana Ferrero Franco Locatelli Rita Maccario Mario Marazzi Ornella Parolini Augusto Pessina | 2013 | Current Pharmaceutical Design2013，，： | 1 |
| 5 | Self-organized porphyrinic materials显示文摘 | CHARLES M D ALESSANDRO V IVANA R | 2009 | Chem Rev2009，109，5： | 1 |
| 6 | incremental transmission loss allocation under pool dispatch 显示文摘 | Galiana F D Conejo A J Kockar Ivana | 2002 | IEEE Trans on Power Systems2002，17，1： | 1 |
| 7 | Nine-Year Single Center Experience With Cervical Mediastinoscopy: Complications and False Negative Rate显示文摘 | Anthony Lemaire Ivana Nikolic Thomas Petersen Jack C. Haney Eric M. Toloza David H. Harpole Thomas A. D’Amico William R. Burfeind | 2006 | The Annals of Thoracic Surgery2006，，4： | 1 |
| 8 | A modified microtiter- plate test for quantification of staphylococcal biofilm formation显示文摘 | Srdjan S Dragana V Ivana D | 2000 | Journal of Microbiological Methods2000，，40： | 1 |
| 9 | A modified microtiter-plate test for quantification of staphylococcal biofilrn formation 显示文摘 | SRDJAN S DRAGANA V IVANA D | 2000 | Microbiol Meth2000，40，： | 1 |
| 10 | Clarification of fruit juices by fungal pectinases显示文摘 | Ivana Greice Sandri Roselei Claudete Fontana Débora Menim Barfknecht Mauricio Moura da Silveira | 2011 | LWT - Food Science and Technology2011，，10： | 1 |
| 11 | A class of low-density parity-check codes constructed based on reed-solomon codes with two information symbols 显示文摘 | IVANA D | 2003 | IEEE Commun Lett2003，7，7： | 1 |
| 12 | 3D reinforcement of stiffener-to-skin T-joints by Z-pinning and tufting显示文摘 | Denis D R Carrie Giuseppe Dell Anno Emilie Poulin Ivana K Partridge | 2006 | Engineering Fracture Mechanics2006，73，16： | 1 |
| 13 | Endothelin in human inflammatory bowel disease: comparison to rat trinitrobenzenesulphonic acid-induced colitis显示文摘 | Sara A McCartney Anne B Ballinger Ivana Vojnovic Michael J.G Farthing Timothy D Warner | 2002 | Life Sciences2002，，： | 1 |
| 14 | A review of concentrating solar power plants in the world and their potential use in Serbia显示文摘 | Tomislav M Pavlovic Ivana S Radonjic Dragana D Milosavl- jevic | 2012 | Renewable and Sus- tainable Energy Reviews2012，16，6： | 1 |
| 15 | Determination of vinyl chloride monomer in food contact materials by solid phase microextraction coupled with gas Chromatography/Mass Spectrometry显示文摘 | IVANA J JAROSLAV D MICHAL V | 2003 | Czech Journal of Food Sciences2003，21，1： | 1 |
| 16 | Exploring mechanical property balance in tufted carbon fabric/epoxy composites 显示文摘 | Giuseppe Dell Anno Denis D Cartie Ivana K Partridge Amir Rezai | 2007 | Composites2007，38，： | 1 |
| 17 | Hypertension induces brainβ-Amyloid accumulation,cognitive impairment,and memory deterioration through activation of receptor for advanced glycation end Products in Brain显示文摘 | Daniela C Giada M ivana D | 2012 | Hypertension2012，60，1： | 1 |
| 18 | Delamination resistant laminates by Z-fiber pirming: Part Ⅰ nlanufaeture and fracture performance显示文摘 | Ivana K Partridge Denis D R Cartie | 2005 | Composites: Part A2005，36，1： | 1 |
| 19 | The prevention of radiocontrast-agent-induced nephropathy by hemofiltration显示文摘 | Giancarlo Marenzi M D Ivana Marana M D Gianfranco Lauri | 2003 | N Engl J Med2003，349，： | 1 |
| 20 | Effects of allopurinol on oxygen stress status during open heart surgery显示文摘 | Zoran P Juraj F Ivana D | 1994 | Int J Cardiol1994，44，2： | 1 |
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