|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | FibroSURE^(TM) and FibroScan~ in relation to treatment response in chronic hepatitis C virus显示文摘AIM:To compare histological endpoint assessment using noninvasive alternatives to biopsy during treatment in a chronic hepatitis C virus(HCV)cohort.METHODS:Patients with chronic HCV were randomized to receive interferon-based therapy for 24(genotypes 2/3)or 48(genotype 1)wk.FibroSURE~TM(FS)was assessed at baseline and at week-12 post-treatment follow-up.Baseline biopsy for METAVIR was assessed by a single pathologist.FibroScan~ transient elastogra-phy(TE)was performed during treatment in a patient subset.RESULTS:Two thousand and sixty patients(n = 253 in Asia)were classif ied as METAVIR F0-1(n = 1682)or F2-4(n = 378).For F2-4,FS(n = 2055)had sensitiv-ity and specif icity of 0.87 and 0.61,respectively,with area under the receiver-operating curve of 0.82;corre-sponding values for TE(n = 214)and combined FS/TE(n = 209)were 0.77,0.88 and 0.88,and 0.93,0.68 and 0.88.Overall FS/TE agreement for F2-4 was 71%(κ = 0.41)and higher in Asians vs non-Asians(κ = 0.86 vs 0.35;P < 0.001).Combined FS/TE had 97% accuracy in Asians(n = 33).Baseline FS(0.38 vs 0.51,P < 0.001)and TE(8.0 kPa vs 11.9 kPa,P = 0.006)scores were lower in patients with sustained virological response than in nonresponders,and were maintained through follow-up.CONCLUSION:FS and TE may reliably differentiate mild from moderate-advanced disease,with a potential for high diagnostic accuracy in Asians with chronic HCV. | Keyur Patel Mireen Friedrich-Rust Yoav Lurie Mircea Grigorescu Carol Stanciu Chuan-Mo Lee Eugene R Schiff Dieter Hussinger Michael P Manns Guido Gerken Isabelle Colle Michael Torbenson Erik Pulkstenis G Mani Subramanian John G McHutchison Stefan Zeuzem | 2011 | World Journal of Gastroenterology2011，17，41： | 4 |
| 2 | Specificity and nucleotyping studies of a gpSO - based polymerase chain reaction assay for detection of Pseudorabies virus 显示文摘 | HARDING M J ISABELLE P H JERZY R | 1997 | Can J Vet Res1997，61，： | 1 |
| 3 | Breast cancer,lactation history, and serum organochlorines显示文摘 | Isabelle R Mauricio H A Eduardo L P | 2000 | American Journal of Epidemiology2000，152，4： | 1 |
| 4 | Detection of a Whitening Fluorescent Agent as an Indicator of White Paper Biodegradation: a New Approach to Study the Kinetics of Cel- lulose Hydrolysis by Mixed Cultures显示文摘 | ISABELLE B H MARIE P LAURENT S | 1999 | Journal of Microbio- logical Methods1999，37，： | 1 |
| 5 | Increased syphilis trend among patients in an AIDS information and prevention center 显示文摘 | Isabel H Ignacio A Menelaos P | 2011 | Gaceta Sanitaria2011，25，5： | 1 |
| 6 | Preconcentration of Zn(Ⅱ) in water samples using a new hybrid SBA-15-based material显示文摘 | DAMIAN P Q ALFREDO S ISABEL D H | 2009 | J Hazard Mater2009，166，23： | 1 |
| 7 | Perspectives:towards a peptide-based vaccine against hepatitis C virus显示文摘 | Isabelle P Rinaldo H Marfire G | 2001 | Mol Immunol2001，38，： | 1 |
| 8 | MEMSSensors for Density-Viscosity Sensing in a Low-Flow Mi-crofluidic Environment显示文摘 | Etchart Isabelle CHEN H Dryden P | 2008 | Sensors and Actuators A2008，141，2： | 1 |
| 9 | Differential value of adenosine myocardial contrast echocardiography and dobutamine stress echocardiography in evaluating functional significance of coronary artery stenosis in a porcine model显示文摘 | Stefan EH Isabell P Alexander H et a1 | 2001 | Basic Res Cardiol2001，96，4： | 1 |
| 10 | Detection and Quantification of Bovine, Ovine and Caprine Milk Percentages in Protected Denomination of Origin Cheeses by Reversed-phase High-performance Liquid Chromatography of Beta -lac toglobulins 显示文摘 | Isabel M P L Ferreiravo Cacote H | 2003 | J C hromatogr A2003，1015，： | 1 |
| 11 | Detection and Quantification of Bovine,Ovine and Caprine Milk Percentages in Protected Denomination of Origin Cheeses by Reversed-phase High-performance Liquid Chromatography of Beta-lactoglobulins显示文摘 | ISABEL M P L FERREIRA V O CACOTE H | 2003 | J Chromatogr A2003，1015，： | 1 |
| 12 | Method optimization by solid-phase micro extraction in combination with gas chromatography with mass spectrometry for analysis of beer volatile fraction显示文摘 | Olivia P Isabel M P L V O Ferreira Lucia H M L M | 2006 | Journal of Chromatography A2006，11，21： | 1 |
| 13 | Defining DIOS and Constipation in Cystic Fibrosis With a Multicentre Study on the Incidence, Characteristics, and Treatment of DIOS显示文摘 | Roderick H Houwen Hubert P van der Doef Isabelle Sermet Anne Munck Bruno Hauser Jaroslaw Walkowiak Eddy Robberecht Carla Colombo Maarten Sinaasappel Michael Wilschanski | 2010 | Journal of Pediatric Gastroenterology and Nutrition2010，，1： | 1 |
| 14 | Construction of an Actinobacillus pleuropneumoniae serotype 2 prototype live negative-marker vaccine显示文摘 | Walaiporn T Nina B Isabel H P | 2002 | Infection and Immunity2002，70，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员