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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | The central nervous system and HRT 显示文摘 | Santiago P Isabel C Carman M | 2000 | Int J Fertil2000，45，1： | 1 |
| 3 | Effects of fertilization and tillage on soil biological parameters 显示文摘 | Iker M Roberto P Isabel A | 2006 | Enzyme and Microbial Technology2006，40，： | 1 |
| 4 | Efficiency and its determinants in Portuguese hotels in the Algarve显示文摘 | Ricardo O Maria Isabel P Rui C M | 2013 | Tourism Management2013，36，2： | 1 |
| 5 | Prevalence of Salmonella on Raw Poultry at Retail Markets in China显示文摘 | Yang Baowei Xi Meili Wang Xin Cui Shenghui Yue Tianli Hao Hongshan Wang Yin Cui Yue Alali W Q Meng Jianghong Walls Isabel Wong D M Lo Fo Doyle M P | 2011 | Journal of Food Protection2011，，10： | 1 |
| 6 | Specificity and nucleotyping studies of a gpSO - based polymerase chain reaction assay for detection of Pseudorabies virus 显示文摘 | HARDING M J ISABELLE P H JERZY R | 1997 | Can J Vet Res1997，61，： | 1 |
| 7 | Formation of PVP - protected metal nanopartical in DMF 显示文摘 | Isabel P S Luis M L | 2002 | Langmuir2002，，18： | 1 |
| 8 | Formation and stabilization of silver nanopartieles through reduction by N, N - dimethylformamide 显示文摘 | Isabel P S Luis M L | 1999 | Langmuir1999，15，4： | 1 |
| 9 | Pyrroline-5-carboxylate synthase and proline biosynthesis :from osmotoleranee to rare met- abolic disease 显示文摘 | Isabel P A Francisco C A Ana I M | 2010 | Protein Sci2010，19，： | 1 |
| 10 | Baptista,sol-gel preparation of lead zirconate titanate powders and ceramics: effect of alkoxide stabilizers and leadprecursors显示文摘 | Wu A Y Vilarinho P M Isabel M | 2000 | J Am Ceram Soc2000，83，6： | 1 |
| 11 | The Demand-Control-Sup-port model, locus of control and job dissatisfaction: a longitudinal study显示文摘 | Isabel R M J Bravo Jose M P | 2001 | Work & Stress2001，15，2： | 1 |
| 12 | Chromosomal polymorphism,morphometric traits and matingsuccess in Leptysma argentina Brunet (Orthoptem) Genetica显示文摘 | Pensel S Isabel R M | 2004 | Genetica2004，121，： | 1 |
| 13 | Formation and Stabilization of Silver Nanoparticles through Reduction by N, N-Dimethylformamide显示文摘 | P S Isabel M L Luis | 1999 | Langmuir1999，15，： | 1 |
| 14 | The effect of anchor voices and visible speech in training in the GRABS scale of perceptual evaluation of dysphonia显示文摘 | FAUSTINO N B JUAN P D M ISABEL G L | 2012 | Acta Otorrinolaringológica Espa1ola2012，63，： | 1 |
| 15 | The central nervous system and HRT显示文摘 | Santiago P Isabel C Carman M | 2000 | Int J Fertil2000，45，1： | 1 |
| 16 | The effect of phosphate concentration on growth and agar content of Gelidium robustum(Gelideaceae,Rhodophyta) in culture显示文摘 | Isabel S P Lewis R Fuller M P | 1996 | Hydrobiologia1996，，： | 1 |
| 17 | Formation of PVP-Protected Metal Nanoparticles in DMF显示文摘 | P S Isabel M L Luis | 2002 | Langmuir2002，18，： | 1 |
| 18 | Effects of the combination of hydrophobic polypeptides,iso-αacids,and malto-oligosaccharides on beer foam stability显示文摘 | Isabel M P L V O F Erreira Kaa Tia Jorge Luciana C Nogueira | 2005 | J Agric Food Chem2005，53，12： | 1 |
| 19 | Microbial conversion of glycerol to 1,3-propanediol: Physiological comparison of a natural producer, Clostridium butyricum VPI 3266, and an engineered strain,Clostridium acetobuty- licum DG1 (pSPD5) 显示文摘 | MARIA G P ISABELLE M S FILIPA M | 2006 | Applied and Environmental Microbiology2006，72，1： | 1 |
| 20 | Biochar: A Synthesis of Its Agronomic Impact beyond Carbon Sequestration显示文摘 | Spokas Kurt A Cantrell Keri B M Novak Jeffrey Archer David W Ippolito James A Collins Harold P Boateng Akwasi A Lima Isabel M Lamb Marshall C McAloon Andrew J Lentz Rodrick D Nichols Kristine A | 2012 | Journal of Environmental Quality2012，，4： | 1 |
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