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| 1 | Management and therapy of vasovagal syncope: A review显示文摘Vasovagal syncope is a common cause of recurrent syncope. Clinically, these episodes may present as an isolated event with an identifiable trigger, or manifest as a cluster of recurrent episodes warranting intensive evaluation. The mechanism of vasovagal syncope is incompletely understood. Diagnostic tools such as implantable loop recorders may facilitate the identification of patients with arrhythmia mimicking benign vasovagal syncope. This review focuses on the management of vasovagal syncope and discusses the non-pharmacological and pharmacological treatment options, especially the use of midodrine and selective serotonin reuptake inhibitors. The role of cardiac pacing may be meaningful for a subgroup of patients who manifest severe bradycardia or asystole but this still remains controversial. | Muhammet Ali Aydin Tushar V Salukhe Iris Wilke Stephan Willems | 2010 | World Journal of Cardiology2010，2，10： | 8 |
| 2 | Enhanced expression of interleukin-18 in serum and pancreas of patients with chronic pancreatitis显示文摘AIM: To investigate interleukin-18 (IL-18) in patients with chronic panreatitis (CP). METHODS: We studied 29 patients with CP and 30 healthy controls. Peripheral blood mononuclear cells (PBMC) were isolated and incubated with 50 mmol/L ethanol, lipopolysaccharide (LPS) (doses 25 g/L, 250 g/L, 2500 g/L) and both agents for 24 h. Levels of IL-18 in the supernatants, and levels of IL-18, IL-12, interferon (IFN)-γ and soluble CD14 in the serum were analysed by ELISA technique. Expression of IL-18 in PBMC was investigated by reverse-transcription (RT)-PCR. IL-18 protein levels in CP tissue and in normal pancreas were studied by ELISA technique. IL-18 levels in PBMC and pancreatic tissue were determined by Westernblot. Im-munohistochemistry for pancreatic IL-18 expression was performed. RESULTS: In patients, IL-18 serum levels were signifi-cantly enhanced by 76% (mean: 289.9 ± 167.7 ng/L) compared with controls (mean: 165.2 ± 43.6 ng/L; P < 0.0005). IL-12 levels were enhanced by 25% in patients (18.3 ± 7.3 ng/L) compared with controls (14.7 ± 6.8ng/L, P = 0.0576) although not reaching the statistical significance. IFN-γ and soluble CD14 levels were not in-creased. In vitro, LPS stimulated significantly and dose-dependently IL-18 secretion from PBMC. Incubation with ethanol reduced LPS-stimulated IL-18 secretion by about 50%. The mRNA expression of IL-18 in PBMC and the response of PBMC to ethanol and LPS was similar in CP patients and controls. In PBMC, no significant differences in IL-18 protein levels were detected between patients and controls. IL-18 protein levels were increased in CP tissues compared to normal pancreatic tissues. IL-18 was expressed by pancreatic acinar cells and by infiltrating inflammatory cells within the pancreas. CONCLUSION: IL-18 originates from the chronically inflammed pancreas and appears to be involved in the fibrotic destruction of the organ. | Alexander Schneider Stephan L Haas Ralf Hildenbrand Sren Siegmund Iris Reinhard Helmut Nakovics Manfred V Singer Peter Feick | 2006 | World Journal of Gastroenterology2006，12，40： | 4 |
| 3 | Deviation of Residual Stress Patterns in 52100 Bearing Steel by Inherent Microstructure Transformations After Rolling Contact显示文摘 | Iris V R Clayton O R | 2004 | Materials Characterization2004，53，8： | 1 |
| 4 | Deviation of residual stress patterns in 52100 bearing steel by inherent microstructural transformations after rolling contact显示文摘 | Iris V R Clayton O R | 2004 | Materials Characterization2004，53，8： | 1 |
| 5 | Detection of the effects of dopamine receptor supersensitivity using pharmacological MRI and correlations with PET显示文摘 | Nguyen T V Brownell A L Iris Chen Y C Livni E Coyle J T Rosen B R Cavagna F Jenkins B G | | 0，，01： | 1 |
| 6 | Extended-depth-ofo unrestored wavefront-coded imagery显示文摘 | BODDETI V N KUMAR B field iris recognition using V K V | 2010 | IEEE Transactions on Systems Man and Cy- bernetics Part A2010，40，3： | 1 |
| 7 | A survey of literature on automated storage and retrieval systems显示文摘 | KEES J R IRIS F A V | 2009 | European Journal of Operational Research2009，194，2： | 1 |
| 8 | Plant L-ascorbic acid:chemistry,function,metabolism,bioavailability and effects of processing显示文摘 | DAVEY M W MONTAGU M V INZéD S MAITE K ANGELOS S NICHOLAS B IRIS J J S JOHN J F DEREK F JOHN | 2000 | Journal of the Science of Food and Agriculture2000，80，7： | 1 |
| 9 | Current routes in polycrystalline CuInSe2 andCu(In,Ga)Se2 films显示文摘 | AZULAY D MILLO O BALBERG I SCHOCK H W IRIS V F DAVID C | 2007 | Solar Energy Materials and Solar Cells2007，91，1： | 1 |
| 10 | Research in Information Systems:An Empirical Study of Diversity in the Discipline and Its Journals 显示文摘 | Iris Vessey V Ramesh Robert L Glass | 2002 | Journal of Management Information Systems2002，19，2： | 1 |
| 11 | Characterizing water and solute Movement by Time Domain Reflectometry显示文摘 | Iris V Brent E C Steven R G | 1996 | Soil Sci Soc Am J1996，60，： | 1 |
| 12 | Modeling of residual stress distribution in D2 steel via grinding dynamics using a second-order damping system 显示文摘 | Olga Karabelchtchikova Iris V Rivero Simon M Hsiang | 2008 | Journal of Materials Processing Technology2008，，198： | 1 |
| 13 | Survey of Research in the Design and Control of Automated Guided Vehicle Systems显示文摘 | Iris F A V | 2006 | European Journal of Operational Research2006，17，： | 1 |
| 14 | Scale space segmentation of color Image using watersheds and fuzzy region merging显示文摘 | SOKRATIS M IRIS V SAHLI H | 2001 | IEEE International Conference on Image Processing2001，，1： | 1 |
| 15 | Risk management processes in supplier networks显示文摘 | Iris K Urho P Veli-Matti V Markku T | 2004 | International Journal of Production Econcmics2004，90，： | 1 |
| 16 | Distinct roles of Aktl and Akt2 in regulating cell migration and epithelial - mesenchymal transition显示文摘 | IRIE H Y PEARLINE R V GRUENEBERG D | 2005 | J Cell Biol2005，171，6： | 1 |
| 17 | A survey of literature on automated storage and retrieval systems显示文摘 | Kees J R Iris F A V | 2009 | European Journal of Operational Research2009，3，2： | 1 |
| 18 | Survey of research in the design and controlof automated guided vehicle systems 显示文摘 | Iris F A V | 2006 | European Journal of Operational Research2006，，170： | 1 |
| 19 | Distinct roles of Aktl andAkt2 in regulating cell migration and epithelial-mesenchymal transition显示文摘 | Irie H Y Pearline R V Grueneberg D | 2005 | Cell Biol2005，171，14： | 1 |
| 20 | Risk management processes in supplier networks显示文摘 | Jukka H Iris K Urho P Veli-Matti V Markku T | 2004 | International Journal of Production Economics2004，90，： | 1 |
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