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| 1 | Primary liposarcoma of esophagus:A case report显示文摘当食道的脂肪的肉瘤是一个极其稀罕的肿瘤时,脂肉瘤是在成年生命的最普通的软织物肉瘤。在世界文学,仅仅食道的脂肪的肉瘤的 14 个案例被描述了。我们报导着急地与一枚燃烧制动火箭为剧烈腹上部的疼痛进入我们的医院的一个 72 年的老男病人胸骨的感觉,坚持的恶心,呕吐并且咽下困难。钡燕子,上面胃肠(官方补给) 内视镜检查法,食道的测压法和 CT 扫描,没能精确地诊断损害。在一个食道的息肉样瘤的外科的切除术以后,组织学的考试揭示了一个区分得好的等级我脂肪的肉瘤。诊断、治疗学的工具被讨论,文学的结果被考察。 | Theodore D Liakakos Theodore G Troupis Charalambos Tzathas Konstantina Spirou Irene Nikolaou Spiridon Ladas Gabriel M Karatzas | 2006 | World Journal of Gastroenterology2006，12，7： | 5 |
| 2 | Preclinical evaluation of azathioprine plus buthionine sulfoximine in the treatment of human hepatocarcinoma and colon carcinoma显示文摘AIM: To evaluate the efficacy and the safety of azathioprine (AZA) and buthionine sulfoximine (BSO) bylocalized application into HepG2 tumor in vivo.METHODS: Different hepatoma and colon carcinoma cell lines (HepG2, HuH7, Chang liver, LoVo, RKO, SW-48, SW-480) were grown in minimal essencial medium supplemented with 10% fetal bovine serum and 1% antibiotic/antimycotic solution and maintained in a humidified 37 ℃ incubator with 5% CO2. These cells were pretreated with BSO for 24 h and then with AZA for different times. We examined the effects of this combination on some proteins and on cellular death. We also studied the eff icacy and the safety of AZA (6 mg/kg per day) and BSO (90 mg/kg per day) in HepG2 tumor growth in vivo using athymic mice. We measured safety by serological markers such as aminotransferases and creatine kinase.RESULTS: The in vitro studies revealed a new mechanism of action for the AZA plus BSO combination in the cancer cells compared with other thiopurines (6-mercaptopurine, 6-methylmercaptopurine, 6-thioguanine and 6-methylthioguanine) in combination with BSO. The cytotoxic effect of AZA plus BSO in HepG2 cells resulted from necroptosis induction in a mitochondrial-dependent manner. From kinetic studies we suggest that glutathione (GSH) depletion stimulates c-Jun amino-terminal kinase and Bax translocation in HepG2 cells with subsequent deregulation of mitochondria (cytochrome c release, loss of membrane potential), and proteolysis activation leading to loss of membrane integrity, release of lactate dehydrogenase and DNA degradation. Some of this biochemical and cellular changes could be reversed by N-acetylcysteine (a GSH replenisher). In vivo studies showed that HepG2 tumor growth was inhibited when AZA was combined with BSO.CONCLUSION: Our studies suggest that a combination of AZA plus BSO could be useful for localizedtreatment of hepatocellular carcinoma as in the currently used transarterial chemoembolization method. | Borja Hernández-Breijo Jorge Monserrat Sara Ramírez-Rubio Eva P Cuevas Diana Vara Inés Díaz-Laviada M Dolores Fernández-Moreno Irene D Román Javier P Gisbert Luis G Guijarro | 2011 | World Journal of Gastroenterology2011，17，34： | 2 |
| 3 | A vital sugar code for ricin toxicity显示文摘 | Jasmin Taubenschmld Johannes Stadlmann Markus Jost Tove Irene Klok.k Cory D Rillahan Andreas Leibbrandt Karl Mechtler James C Paulson Julian Jude Johannes Zuber Kirsten Sandvig Ulrich Elling Thorsten Marquardt Christian Thiel Christian Koerner Josef M Penninger | 2017 | Cell Research2017，27，11： | 2 |
| 4 | ALLENEOXIDE CYCLASE (AOC) gene family members of Arabidopsis thaliana : tissue-and organ-spe- cific promoter activities and in vivo heteromerization显示文摘 | IRENE S OTTO M CAROLIN D | 2012 | J Exp Bot2012，63，17： | 1 |
| 5 | The small GTPase Rab13 regulates assembly of functional tight junctions in epithelial cells显示文摘 | Anne M Irene D Rudy P | 2002 | Mol Biol Cell2002，13，： | 1 |
| 6 | Lower extremi- ty stiffness: implications for performance and injury显示文摘 | ROBERT J B HARRISON P C IRENE M D | 2003 | Clin Biomech2003，118，6： | 1 |
| 7 | A comparative study of Li-ion battery, supercapacitor and nonaqueous asymmetric hybrid devices for automotive applications 显示文摘 | AIjRE'LIEN D P IRENE P SERAFIN M | 2003 | J Power Sources2003，，： | 1 |
| 8 | Effect of Different Concentrations of Carbon Dioxide and Low Concentration of Carbon Monoxide on the Shelf life of Fresh Pork Sausages Packaged in Modified Atmosphere 显示文摘 | LUIS M DJAMEL D IRENE C | 2005 | Meat science2005，71，： | 1 |
| 9 | Identification and biodegradation potential of a novel strain of Dietzia cinnamea isolated from a petroleum-contaminated tropieal soil显示文摘 | Irene van der Weid Joana M Marques Claudia D Cunha | 2007 | Systematic and Applied Microbiology2007，30，： | 1 |
| 10 | The role of hyaluronic acid in wound healing:assessment of clinical evidence显示文摘 | Richard D Simon M Irene M | 2005 | Am J Clin Derm2005，6，6： | 1 |
| 11 | A comparative study of Li-ion battery,supercapacitor and nonaqueous asymmetric hybrid devices for automotive applications显示文摘 | AURELIIEN D P IRENE P SERAFIN M | 2003 | J Power Sources2003，115，： | 1 |
| 12 | Effect of different concentrations of carbon dioxide and low concentration of carbon monoxide on the shelf-life of fresh pork sausages packaged in modified atmosphere显示文摘 | LUIS M DJAMEL D IRENE C | 2005 | Meat Science2005，71，： | 1 |
| 13 | Molecular monitoring of human intestinal Bifidobacterium strain diversity显示文摘 | Irene M Yoram B Bernard D | 1999 | Research in Microbiology1999，150，： | 1 |
| 14 | Determination of properties of Pinhao starch : Analysis of its applicability as pharma- ceutical excipient 显示文摘 | RENATA M D IRENE C KG FLORENCIA C O | 2014 | Industrial Crops and Products2014，52，： | 1 |
| 15 | The interface between titanium and carbon nanotubes显示文摘 | ALEXANDRE F IRENE S M XIAOXING K GUSTAAF V T JACQUES G JEAN J P WOLGANG D CARLA B CHRISTOPHER P | 2009 | A European Journal of Chemical Physics and Physical Chemistry2009，10，： | 1 |
| 16 | Identification and biodegradation potential of a novel strain of dietzia cinnamea isolated from a petroleum - contaminated tropical soil显示文摘 | Irene V W Joana M M Claudia D C | 2007 | Systematic and Applied Microbiology2007，30，4： | 1 |
| 17 | 16S rRNA and 16S to 23S internal transcribed spacer sequence analysis reveal inter and intraspecific Bifidobacterium phylogeny显示文摘 | Nathalie LB Herve P Irene M Bernard D | 1996 | International Journal of Systematic and Evolutionary Microbiology1996，，46： | 1 |
| 18 | A novel multi-shot target platform for laser-driven laboratory astrophysics experiments显示文摘A new approach to target development for laboratory astrophysics experiments at high-power laser facilities is presented.With the dawn of high-power lasers,laboratory astrophysics has emerged as a field,bringing insight into physical processes in astrophysical objects,such as the formation of stars.An important factor for success in these experiments is targetry.To date,targets have mainly relied on expensive and challenging microfabrication methods.The design presented incorporates replaceable machined parts that assemble into a structure that defines the experimental geometry.This can make targets cheaper and faster to manufacture,while maintaining robustness and reproducibility.The platform is intended for experiments on plasma flows,but it is flexible and may be adapted to the constraints of other experimental setups.Examples of targets used in experimental campaigns are shown,including a design for insertion in a high magnetic field coil.Experimental results are included,demonstrating the performance of the targets. | Pablo Perez-Martin Irene Prencipe Manfred Sobiella Fabian Donat Ning Kang Zhiyu He Huiya Liu Lei Ren Zhiyong Xie Jun Xiong Yan Zhang Florian-Emanuel Brack MichalČervenák Pavel Gajdoš Lenka Hronová Kakolee Kaniz Michaela Kozlová Florian Kroll Xiayun Pan Gabriel Schaumann Sushil Singh MichalŠmíd Francisco Suzuki-Vidal Panzheng Zhang Jinren Sun Jianqiang Zhu Miroslav Krůs Katerina Falk | 2023 | High Power Laser Science and Engineering2023，11，2： | 0 |
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