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| 1 | Contribution of the IL-17/IL-23 axis to the pathogenesis of inflammatory bowel disease显示文摘Inflammatory bowel diseases(IBDs) are chronic disorders of modern society, requiring management strategies aimed at prolonging an active life and establishing the exact etiology and pathogenesis.These idiopathic diseases have environmental, genetic,immunologic, inflammatory, and oxidative stress components. On the one hand, recent advances have shown that abnormal immune reactions against the microorganisms of the intestinal flora are responsible for the inflammation in genetically susceptible individuals. On the other hand, in addition to T helper cell-type(Th) 1 and Th2 immune responses,other subsets of T cells, namely regulatory T cells and Th17 maintained by IL-23 are likely to develop IBD. IL-23 acts on innate immune system members and also facilitates the expansion and maintenance of Th17 cells. The IL-17/IL-23 axis is relevant in IBD pathogenesis both in human and experimental studies. Novel biomarkers of IBD could be calprotectin,microRNAs, and serum proinflammatory cytokines.An efficient strategy for IBD therapy is represented by the combination of IL-17 A and IL-17 F in acute IL-17 A knockout TNBS-induced colitis, and also definite decrease of the inflammatory process in IL-17 F knockout, DSS-induced colitis have been observed.Studying the correlation between innate and adaptive immune systems, we hope to obtain a focused reviewin order to facilitate future approaches aimed at elucidating the immunological mechanisms that control gut inflammation. | Cristina-Sorina Cǎanǎ Ioana Berindan Neagoe Vasile Cozma Cristian Magdas Flaviu Tǎbǎan Dan Lucian Dumitrasu | 2015 | World Journal of Gastroenterology2015，21，19： | 37 |
| 2 | Impact of BAL on the diagnosis and treatment of nosocomial pneumonia in ICU pa- tients显示文摘 | FERRER R IOANAS M AGUSTI C | 2001 | Monaldi Arch Chest Dis2001，56，6： | 1 |
| 3 | High plasma levels of COL10A1 are associated with advanced tumor stage in gastric cancer patients显示文摘BACKGROUND Gastric cancer(GC)remains an aggressive malignancy with a high rate of mortality,being the third leading cause of cancer-related death.More than one million newly diagnosed cases and 782685 deaths due to GC were reported in 2018.GC is characterized by limited effective treatment options and the lack of consistent biomarkers for the diagnosis and prognosis of these patients.The discovery of new biomarkers useful in the early diagnosis of GC is mandatory.AIM To evaluate the potential of COL10A1 as a circulating biomarker for the diagnosis and prognosis of gastric adenocarcinoma patients.METHODS Plasma and tissue obtained from 49 patients with gastric adenocarcinoma have been used in exploring the expression of COL10A1.Real-time PCR and western blot techniques were used to evaluate COL10A1 level in gastric tumor tissue compared to normal adjacent tissue.The circulating level of COL10A1 was also evaluated by ELISA in plasma of gastric adenocarcinoma patients.Survival analysis was made in order to evaluate the potential of COL10A1 as a biomarker for the diagnosis and prognosis of gastric adenocarcinoma patients.RESULTS Our results showed a significant increase in COL10A1 gene expression and protein levels in gastric tumor tissue compared to adjacent normal tissue(P<0.05).COL10A1 seems to show an elevated expression from the beginning of carcinogenesis,in the early stages,and its increased level remains elevated during cancer progression.A significant increase of COL10A1 plasma level in gastric adenocarcinoma patients was also identified.Moreover,increased COL10A1 plasma level was associated with poor survival of the patients.Plasma COL10A1 performed a diagnostic value in GC with area under the receiver operating characteristic curve(AUC)of 0.9171(P=0.0002),sensitivity of 87.76%,and specificity of 100.0%.Furthermore,this study demonstrated the potential role of plasma COL10A1 in the early detection of GC,as in the early stage,we obtained an AUC of 0.8789(P=0.0030),sensitivity of 81.25%,and specificity of 100.0%.CONCLUSION Circulating expression level of COL10A1 is significantly increased in gastric adenocarcinoma patients being associated with poor survival and is a potential biomarker for early detection of GC. | Laura Necula Lilia Matei Denisa Dragu Ioana Pitica Ana Iulia Neagu Coralia Bleotu Simona Dima Irinel Popescu Carmen C Diaconu Mihaela Chivu-Economescu | 2020 | World Journal of Gastroenterology2020，26，22： | 1 |
| 4 | Modeling and characterization of damping in carbon nanofiber/polypropylene composites显示文摘 | GARY G TIBBETTS and RONALD F GIBSON | 2003 | Composites Science and Technology2003，63，11： | 1 |
| 5 | Hydrogen isotope separation by permeation through palladium membranes显示文摘 | MANFRED G IOANA R ION C | 2006 | Journal of Nuclear Materials2006，255，123： | 1 |
| 6 | Recent Research on Enhancement of Damping in Polymer Composites显示文摘 | Ioana C Finegan Ronald F Gibson | 1999 | Composite Structures1999，，44： | 1 |
| 7 | Impact of BAL on the diagnosis and treatment of nosocomial pneumonia in ICU patients显示文摘 | Ferret R Ioanas M Agusti C | 2001 | MonaldiArch Chest Dis2001，56，6： | 1 |
| 8 | Acoustic radiation force impulse quantitative elastography: a new noninvasive technique for the evaluation of parotid glands, a preliminary study in controls and in patients with irradiated nasopharyngeal carcinoma 显示文摘 | Iulia B Attila T S Ioana C Maria C Elisabeta C Grigore B Mindra B | 2015 | Medical Ultrasonography2015，17，3： | 1 |
| 9 | Recent research on enhancement of damping in polymer composites 显示文摘 | Ioana C F Ronald F G | 1999 | Composite Structures1999，44，： | 1 |
| 10 | Source motion detection, estimation, and compensation for under-water acoustics inversion by wideband ambiguity lag- Doppler filtering显示文摘 | Josso N F Ioana C Mars J I | 2010 | Journal of the Acoustical Society of America2010，128，6： | 1 |
| 11 | Recent research on enhancement of damping in polymer composites 显示文摘 | IOANA C F RONALDO F | 1999 | Composite Structures1999，44，： | 1 |
| 12 | Generalized representation of phase derivatives for regular signals 显示文摘 | CORNU C STANKOVIC S IOANA C | 2007 | IEEE Trans on SP2007，55，10： | 1 |
| 13 | Analytical modeling of damping at micromechanical level in polymer composites reinforced with coating fibers 显示文摘 | FINEGAN I C IOANA C GIBSON R F | 2002 | Comp Sci Techn2002，60，7： | 1 |
| 14 | Impact of BAL on the diagnosis and treatment of nosocomial pneumonia in ICU patients显示文摘 | Ferrer R Ioanas M Agusti C | 2001 | Monaldi Arch Chest Dis2001，56，6： | 1 |
| 15 | General form of time- frequency distribution with complex-lag argument显示文摘 | Stankovic S Zaric N Orovic I Ioana C | 2008 | Eleclxon- ics Letters2008，44，11： | 1 |
| 16 | Generalized representation of phase derivatives for regular signals显示文摘 | Cornu C Stankovic S Ioana C | 2007 | IEEE Transactions on Signal Processing2007，55，10： | 1 |
| 17 | Effects of cauchy integral for- mula discretization on the precision of IF estimation: unified approach to complex-lag distribution and its counterpart L- form 显示文摘 | Stankovic S Orovic I Ioana C | | IEEE Signal Processing Letters0，16，4： | 1 |
| 18 | Generalized representation derivatives for regular signals显示文摘 | Comu C Stankovic S Ioana C Quinquis A Stankovic L J | 2007 | IEEE Transactions on Signal Processing2007，55，10： | 1 |
| 19 | Modeldriven design and deployment of service-enabled web applications显示文摘 | IOANA M MARCO B STEFANO C | 2005 | ACM Transactions on Internet Technology2005，5，3： | 1 |
| 20 | Model-driven Design and Development of Service-enabled Web Applications显示文摘 | Ioana M Marco B Stefeno C | 2005 | ACM Transactions on Internet Technology2005，5，3： | 1 |
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