|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Release of interleukin-10 and neurotrophic factors in the choroid plexus:possible inductors of neurogenesis following copolymer-1 immunization after cerebral ischemia显示文摘Copolymer-1(Cop-1) is a peptide with immunomodulatory properties, approved by the Food and Drug Administration of United States in the treatment of multiple sclerosis. Cop-1 has been shown to exert neuroprotective effects and induce neurogenesis in cerebral ischemia models. Nevertheless, the mechanism involved in the neurogenic action of this compound remains unknown. The choroid plexus(CP) is a network of cells that constitute the interphase between the immune and central nervous systems, with the ability to mediate neurogenesis through the release of cytokines and growth factors. Therefore, the CP could play a role in Cop-1-induced neurogenesis. In order to determine the participation of the CP in the induction of neurogenesis after Cop-1 immunization, we evaluated the gene expression of various growth factors(brain-derived neurotrophic factor, insulin-like growth factor 1, neurotrophin-3) and cytokines(tumor necrosis factor alpha, interferon-gamma, interleukin-4(IL-4), IL-10 and IL-17), in the CP at 14 days after ischemia. Furthermore, we analyzed the correlation between the expression of these genes and neurogenesis. Our results showed that Cop-1 was capable of stimulating an upregulation in the expression of the genes encoding for brain-derived neurotrophic factor, insulin-like growth factor 1, neurotrophin-3 and IL-10 in the CP, which correlated with an increase in neurogenesis in the subventricular and subgranular zone. As well, we observed a downregulation of IL-17 gene expression. This study demonstrates the effect of Cop-1 on the expression of growth factors and IL-10 in the CP, in the same way, presents a possible mechanism involved in the neurogenic effect of Cop-1. | Yolanda Cruz Edna E.García Jessica V.Gálvez Stella V.Arias-Santiago Horacio G.Carvajal Raúl Silva-García Herlinda Bonilla-Jaime Julio Rojas-Castaneda Antonio Ibarra | 2018 | Neural Regeneration Research2018，13，10： | 7 |
| 2 | Abrogation of bleomycin- induced epithelial apoptosis and lung fibrosis by captopril or by a caspase inhibitor显示文摘 | Wang R Ibarra - Sunga O Verlinski L | 2000 | Am J Physiol Lung Cell Mol Physiol2000，279，： | 2 |
| 3 | Learning vector quantization for color classification of diseased air sacs in chicken carcasses 显示文摘 | Ibarra J G Tao Y Newberry B L | 2002 | Transation of the ASAE2002，45，5： | 1 |
| 4 | He- patic angiosarcoma: case report and review of literature 显示文摘 | Poggi Maehuca L Ibarra Chirinos O Lopez Del Aguila J | 2012 | Rev Gastroenterol Peru2012，32，3： | 1 |
| 5 | Physical Review B 显示文摘 | Morellon L Algarabel P A Ibarra M R | 1998 | 58(22): R147211998，58，14： | 1 |
| 6 | Photosynthesis, soil temperature and yield of cucumber as affected by colored plastic mulch显示文摘 | IBARRA J L ZERMENO G A MUNGUIA L J | 2008 | Acta Agriculturae Scandinavica (Section B) -Soil and Plant Science2008，58，4： | 1 |
| 7 | Different laccase detoxification strategies for ethanol production from lignocellulosic biomass by the thermotolerant yeast Kluyveromyces marxianus CECT 10875显示文摘 | Moreno A D Ibarra D Fernández J L | 2012 | Bioresource Technology2012，106，2： | 1 |
| 8 | Absorptive Capacity,Innovation Networks and Products:SME in the Basque Country显示文摘 | Spila J C Rocca L Ibarra A | 2010 | International Journal of Innovation and Regional Development2010，，3： | 1 |
| 9 | Dynamic properties of thermoplasticbutadiene-styrene (SBS) and oxidized short carbon fiber compositematerials 显示文摘 | IBARRA L PANOS D | 1998 | JAppl Polym Sci1998，67，： | 1 |
| 10 | Hysteretic model models that incorporate strength and stiffness deterioration 显示文摘 | Ibarra L F Medina R A Krawinkler H | 2005 | Earth- quake Engineering Structural Dynamics2005，34，12： | 1 |
| 11 | Transgenic overexpression of matrix metallo-proteinase-9 in macrophages attenuates the inflammatory response and im-proves left ventricular function post-myocardial infarc- tion显示文摘 | ZAMILPA R IBARRA J DE CASTRO BRAS L E | 2012 | JMolCellCardiol2012，53，： | 1 |
| 12 | Structural and magnetic characterization of the new ternary phase Tb3 (Fe1-xTix)29显示文摘 | Ibarra M R Morellon L Blasco J | 1994 | J Phys Condens Matter1994，，6： | 1 |
| 13 | Complications of the PICC in neurologic patients of the hospital ramony cajal显示文摘 | Ibarra L S Carrero C C | 2013 | Rev Enferm2013，36，10： | 1 |
| 14 | Ionic elastomers based on carboxylated nitrile rubber (XNBR) and calcium oxide显示文摘 | Ibarra L Alzorriz M | 2003 | J Appl Polym Sci2003，87，5： | 1 |
| 15 | Hysteretic models that incorporate strength and stiffness deterioration 显示文摘 | Ibarra L F Medina R A Krawinkler H | 2005 | Earthquake Engineering and Structural Dynamics2005，34，12： | 1 |
| 16 | 显示文摘 | Morellon L Algarabel P A Ibarra M A | 1998 | Phys Rev B1998，58，14： | 1 |
| 17 | Investigation of che- momarkers of astragali radix of different ages and geographical origin by NMR profiling 显示文摘 | Zheng L Wang M Ibarra - Estrada E | 2015 | Molecules2015，20，2： | 1 |
| 18 | Identification of the atomic scale structure of the La 0.65 Nd 0.15 Mg 0.20 Ni 3.5 alloy synthesized by spark plasma sintering显示文摘 | Virginie Serin Junxian Zhang César Magén Rapha?l Serra Martin J. H?tch Lucille Lemort Michel Latroche Manuel Ricardo Ibarra Bernard Knosp Patrick Bernard | 2013 | Intermetallics2013，，： | 1 |
| 19 | 显示文摘 | Morellon L Algarabel P A Ibarra M R | 1998 | Phys Rev B1998，58，14： | 1 |
| 20 | Structural and magnetic properties of double perovskites AA′FeMoO6 (AA′=Ba2,BaSr,Sr2 and Ca)显示文摘 | Ritter C Ibarra M R Morellón L | 2000 | Journal of Physics:Condensed Matter2000，12，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员