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| 1 | Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain (BARD1) gene are associated with breast cancer susceptibility:a case-control analysis显示文摘The BRCA1 Associated RING Domain(BARD1) gene has been identified as a high penetrance gene for breast cancer, whose germline and somatic mutations were reported in both non-BRCA1/2 hereditary site-specific and sporadic breast cancer cases. BARD1 plays a crucial role in tumor repression, along with its heterodimeric partner BRCA1. In the current study, we tested the hypothesis that common non-synonymous polymorphisms in BARD1 are associated with breast cancer susceptibility in a case-control study of 507 patients with incident breast cancer and 539 frequency-matched cancer-free controls in Chinese women. We genotyped all three common(minor allele frequency (MAF) > 0.10) non-synonymous polymorphisms(Pro24Ser, Arg378Ser, and Val507Met) in BARD1. We found that the BARD1 Pro24Ser variant genotypes(24Pro/Ser and 24Ser/Ser) and Arg378Ser variant homozygote 378Ser/Ser were associated with a significantly decreased breast cancer risk, compared with their wild-type homozygotes, respectively. Furthermore, a significant locus-locus interaction was evident between Pro24Ser and Arg378Ser (P-int = 0.032). Among the 378Ser variant allele carriers, the 24Pro/Pro wild-type homozygote was associated with a significantly increased breast cancer risk (adjusted OR = 1.81, 95% CI = 1.11-2.95), but the subjects having 24Pro/Ser or Ser/Ser variant genotypes had a significantly decreased risk(adjusted OR = 0.74, 95% CI = 0.56-0.99). In stratified analysis, this locus-locus interaction was more evident among subjects without family cancer history, those with positive estrogen receptor (ER) and individuals with negative progesterone receptor(PR). These findings indicate that the potentially functional polymorphisms Pro24Ser and Arg378Ser in BARD1 may jointly contribute to the susceptibility of breast cancer. | Huo, X Hu, Z. B Zhai, X. J Wang, Y Wang, S Wang, X. C Qin, J. W Chen, W. S Jin, G. F Liu, J. Y Gao, J Wei, Q. Y Wang, X. R Shen, H. B | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 3 |
| 2 | 高血压患者血清磷酸盐与新发高尿酸血症风险的关系显示文摘血清磷酸盐与新发高尿酸血症的关系仍不确定。该研究对中国脑卒中一级预防试验(China stroke primary prevention trial,CSPPT)的尿酸亚组研究进行事后分析,旨在评估血清磷酸盐与新发高血尿酸症的风险之间的关系。研究包括基线尿酸水平正常(<357μmol/L)的参与者共10612人。主要观察指标是新发高血尿酸症,其定义为男性血尿酸浓度≥417或女性≥357μmol/L。在中位数为4.4年的随访期间,1663名(15.7%)参与者发生了新发高尿酸血症。 | 刘莉(译) 叶鹏(摘、审校) Cao J Zhang J Li Q Jiang C Song Y Liu C Liu L Wang B Li J Zhang Y Cui Y Huo Y Wang X Tang G Xu X Qin X | 2019 | 中华高血压杂志2019，27，6： | 2 |
| 3 | Targeted disruption of cd73/ecto-5'-nueleotidase alters thromboregulation and augments vascular inflammatory response显示文摘 | Koszalka P Ozuyaman B Huo Y | 2004 | Circ Res2004，95，8： | 1 |
| 4 | Triblock copolymer syntheses of mesoporous silica with periodic 50 to 300 angstrom pores显示文摘 | ZHAO D FENG J HUO Q MELOSH N FREDRICKSON G H CHMELKA B F STUCKY G D | 1998 | Science1998，279，5350： | 1 |
| 5 | 2013, Antigenic and genetic characterization of a European avian-like H1N1 swine influenza virus from a boy in China in 2011显示文摘 | Qi x Cui L Jiao Y Pan Y Li X Zu R Huo X Wu B Tang F Song Y Zhou M Wang H Cardona C J Xing Z | 2013 | Archives of Virology2013，158，1： | 1 |
| 6 | The impact of institutional pressures on supplier integration and financial performance: Evidence from China 显示文摘 | Huo B Han Z Zhao X | 2013 | International Journal of Production Economics2013，146，1： | 1 |
| 7 | High-resolution mapping of vehicle emissions in China in 2008显示文摘 | Zheng B Huo H Zhang Q | 2014 | Atmospheric Chemistry and Physics2014，14，18： | 1 |
| 8 | Understanding drivers of performance in the 3PL industry in Hong Kong显示文摘 | Wang Q Huo B Lai F | 2008 | International Journal of Operations & Production Management2008，28，8： | 1 |
| 9 | Nonionic triblock and star diblock copolymer and oligomeric surfactant syntheses of highly ordered, hydrothermally stable, mesoporous silica structures 显示文摘 | ZHAO D HUO Q FENG J CI-IMELKA B STUCKY G | 1998 | J Am Chem Soc1998，120，： | 1 |
| 10 | Studies on the Effectiveness of NaFeEDTA-Forti ]ed Soy Sauce in Controlling Iron Deciency: A Population-Based Intervention Trial 显示文摘 | Chen J Zhao X Zhang X Yin S Piao J Huo J Yu B Qu N Lu Q Wang S Chen C | 2005 | Food and NutritionBulletin2005，26，2： | 1 |
| 11 | The impact of supply chain integration on performance: A contingency and configuration approach显示文摘 | Flynn B B Huo B Zhao X | 2010 | Journal of Operations Management2010，28，1： | 1 |
| 12 | Isolation and characterization of Acidithiobacillus ealdus from several typical environments in China显示文摘 | ZHOU H B LIU X FU B QIU G Z HUO Q ZENG W M LIU J S CHEN X H | 2007 | Journal of Central South University of Technology2007，14，： | 1 |
| 13 | Adaptive maximum power point tracking control of fuel cell power plants显示文摘 | ZHONG Z D HUO H B ZHU X J | 2008 | Journal of Power Sources2008，176，1： | 1 |
| 14 | The Impact of Power and Relationship Commitment on the Integration be- tween Chain 2008, Manufacturers and Customers in a Supply 显示文摘 | ZHAO X D HUO B F | 2008 | Journal of Operations Management2008，26，3： | 1 |
| 15 | Clinical and epidemiologie characteristics of respiratory syncytial virus infection among children aged <5 years, Jingzhou city,China,2011显示文摘 | HUO X FANG B LIU L | 2013 | J Infect Dis2013，208，13： | 1 |
| 16 | Oral dabigatran ver- sus enoxaparin for thromboprophylaxis after primary total hip arthre- plasty ( RE-NOVATEII * )显示文摘 | ERIKSSON B I DAHL O E HUO M H | 2011 | Thromb Haemost2011，105，4： | 1 |
| 17 | Microstructure characteristic of ceramic coatings fabricated on magnesium alloys by micro-arc oxidation in alkaline silieate solutions显示文摘 | GUO H F AN M Z HUO H B XU S WU L J | 2006 | Appl Surf Sci2006，252，22： | 1 |
| 18 | We've Got the Power! How Customer Power Affects Sup- ply Chain Relationships 显示文摘 | BARBARA F ZHAO X D HUO B F | 2008 | Business Horizons2008，51，1： | 1 |
| 19 | The Impact of Supply Chain Inte- gration on Performance: A Contingency and Configuration Ap- proach显示文摘 | Flynn B B Huo B Zhao X | 2010 | Journal of Operations Management2010，28，1： | 1 |
| 20 | The Impact of Supply Chain Integration on Performance:A Contingency and Configuration Approach显示文摘 | FLYNN B B HUO B ZHAO X | 2010 | Journal of Operations Management2010，28，1： | 1 |
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