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| 1 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 2 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 3 | Activated B-cell immunophenotype might be associated with poor prognosis of primary central nervous system lymphomas 显示文摘 | Bhagavathi S Sharalhkumar A Hunter S | 2008 | Clin Neuropathol2008，27，1： | 1 |
| 4 | Adaptation of the maternal heart in pregnancy显示文摘 | Hunter S Robson SC | 1992 | Br Heart J1992，68，6： | 1 |
| 5 | Long-circulating and target-specific nanoparticles :theory to practice显示文摘 | MOGHIMI S M HUNTER A C MURRAY J C | 2001 | Pharmacol Rev2001，53，2： | 1 |
| 6 | Stress and anxiety:structural plasticity and epigenetic regulation as a consequence of stress显示文摘 | McEWEN B S EILAND L HUNTER R G | 2012 | Neuropharmacology2012，62，1： | 1 |
| 7 | Effect of intrathecal magnesium in the presence or absence of local anaesthetic with and without lipophilic opioids : a systematic review and meta-a- nalysis显示文摘 | Morrison A Hunter J Halpern S | 2013 | British Journal of Anaesthesia2013，3，12： | 1 |
| 8 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009，458，7238： | 1 |
| 9 | The dynamic compression testing of solids by the method of the split Hopkinson pressure bar显示文摘 | Davies E D Hunter S C | 1963 | Journal of the Mechanics and Physics of Solids1963，，11： | 1 |
| 10 | Multifaetor experimental de- sign for exploring response surface 显示文摘 | Box G E P Hunter J S | 1957 | Annals of Mathematical Statistics1957，28，： | 1 |
| 11 | Heel pressure ulcers:Stand guard显示文摘 | Langemo D Thompson P Hunter S | 2008 | Adv Skin Wound Car2008，21，6： | 1 |
| 12 | Bromochloro-haloacetic acids: Effects on mouse embryos in vitro and QSAR considerations 显示文摘 | Hunter E S Rogers E Blanton M | 2006 | Reproductive Toxicology2006，21，3： | 1 |
| 13 | Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation显示文摘 | Bagga S Bracht J Hunter S | 2005 | Cell2005，122，4： | 1 |
| 14 | Molecular changes occur-ring during acquisition of abscission competence following auxin de-pletion in Mirabilis jalapa显示文摘 | Meir S Hunter DA Jen~Chih Chen | | 0，，04： | 1 |
| 15 | Cloning and nucleotide sequencing of the Clostridium perfringens epsilon-toxin gene and its expression in Escherichia coli 显示文摘 | HUNTER S E CLARKE I N KELLY D C | 1992 | Infect Immun1992，60，： | 1 |
| 16 | The electrochemical behavior of Al- Ga alloys in alkaline and neutra electrolytes显示文摘 | TUCK C D S HUNTER J A SCAMANS G M | 1987 | J Electrochem Soc1987，10，： | 1 |
| 17 | Outage analysis of coded cooperation显示文摘 | HUNTER T SANAYEI S NOSRATINIA A | 2006 | IEEE Trans Inform2006，52，2： | 1 |
| 18 | Attitude-behavior relations : a meta-analysis of attitudinal relevance and topic 显示文摘 | KIM M S HUNTER J E | 1993 | J Commun1993，43，1： | 1 |
| 19 | Vitamin E biosynthesis : functional characterization of the monocot homogentisate geranylgeranyl transferase 显示文摘 | Yang W Y Cahoon R E Hunter S C | 2011 | The Plant Journal2011，65，： | 1 |
| 20 | The development of a biologically inspired propulsor for unmanned underwater vechicles显示文摘 | TANGORRA J L DAVIDSON S N HUNTER I | 2007 | IEEE Journal of Oceanic Engineering2007，32，3： | 1 |
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