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| 1 | Prediction of coronavirus 3C-like protease cleavage sites using machine-learning algorithms显示文摘The coronavirus 3C-like(3CL)protease,a cysteine protease,plays an important role in viral infection and immune escape.However,there is still a lack of effective tools for determining the cleavage sites of the 3CL protease.This study systematically investigated the diversity of the cleavage sites of the coronavirus 3CL protease on the viral polyprotein,and found that the cleavage motif were highly conserved for viruses in the genera of Alphacoronavirus,Betacoronavirus and Gammacoronavirus.Strong residue preferences were observed at the neighboring positions of the cleavage sites.A random forest(RF)model was built to predict the cleavage sites of the coronavirus 3CL protease based on the representation of residues in cleavage motifs by amino acid indexes,and the model achieved an AUC of 0.96 in cross-validations.The RF model was further tested on an independent test dataset which were composed of cleavage sites on 99 proteins from multiple coronavirus hosts.It achieved an AUC of 0.95 and predicted correctly 80%of the cleavage sites.Then,1,352 human proteins were predicted to be cleaved by the 3CL protease by the RF model.These proteins were enriched in several GO terms related to the cytoskeleton,such as the microtubule,actin and tubulin.Finally,a webserver named 3CLP was built to predict the cleavage sites of the coronavirus 3CL protease based on the RF model.Overall,the study provides an effective tool for identifying cleavage sites of the 3CL protease and provides insights into the molecular mechanism underlying the pathogenicity of coronaviruses. | Huiting Chen Zhaozhong Zhu Ye Qiu Xingyi Ge Heping Zheng Yousong Peng | 2022 | Virologica Sinica2022，37，3： | 1 |
| 2 | Synthesis of N-TiO2@NH2-M IL-88(Fe)Core-shell Structure for Efficient Fenton Effect Assisted Methylene Blue Degradation Under Visible Light显示文摘Core-shell TiO2-based photocatalysts with specific composition,morphology,and functionality have attracted considerable attention for their excellent degradation properties on organic pollutants via a photocatalytic oxidation process.Herein,a N-TiO2@NH2-MIL-88(Fe)core-shell structure was prepared by coating NH2-MIL-88(Fe)on nitrogen-doped TiO2(N-TiO2)nanoparticles.Introduction of heteroatom nitrogen to pure TiOz expands the spectra response range,leading to enhanced quantum efficiency of photocatalyst.Furthermore.loading NH2-MIL-88(Fe)or N-TiOz improved the adsorption ability of the nanocomposites due to the porous tunnels of NH2-MIL-88(Fe).The resulted core-shell N-TiO2@NH2-MIL-88(Fe)nanocomposites realized the transfer of photo excited electrons from N-TiOz to NH2-MIL-88(Fe)rapidly,partially reduced Fe to Fe^2+in NH^2+MIL-88(Fe),and further enhanced the Fenton effect on efficiently degrading methylene blue dye(MB)under visible light(>420 nm)with the assistance of H2O2. | YUAN Huiting REN Huizhen LI Minning LI Zetong LIU Mingrui DONG Wenjun WANG Ge ZHUANG Tao | 2020 | Chemical Research in Chinese Universities2020，36，6： | 0 |
| 3 | Clinical application of 3D reconstruction in pancreatic surgery:a narrative review显示文摘Progress in medicine requires not only innovation and development in the medical field but also the integration of the technology of other fields into the medical field.As an important technological advancement,three-dimensional(3D)reconstruction transforms traditional two-dimensional images into 3D images that are more consistent with the physiological habits of human eyes.It has been applied to the bones,heart,liver,and maxillofacial area,promoting the progress of medical technology and surgeons.This paper introduces the progress of 3D reconstruction technology in the clinical application of pancreatic surgery,from the preoperative,intraoperative,and postoperative perspectives,as well as the education of young surgeons.It also puts forward new ideas for the further development of pancreatic surgery. | Yiming Zhang Yuanyuan Yang Shu Chen Jianbing Ji Huiting Ge Heguang Huang | 2022 | Journal of Pancreatology2022，5，3： | 0 |
| 4 | Clinical application of 3D reconstruction in pancreatic surgery: a narrative review显示文摘Progress in medicine requires not only innovation and development in the medical field but also the integration of the technology of other fields into the medical field. As an important technological advancement, three-dimensional (3D) reconstruction transforms traditional two-dimensional images into 3D images that are more consistent with the physiological habits of human eyes. It has been applied to the bones, heart, liver, and maxillofacial area, promoting the progress of medical technology and surgeons. This article introduces the progress of 3D reconstruction technology in the clinical application of pancreatic surgery, from the preoperative, intraoperative, and postoperative perspectives, as well as the education of young surgeons. It also puts forward new ideas for the further development of pancreatic surgery. | Yiming Zhang Yuanyuan Yang Shu Chen Jianbing Ji Huiting Ge Heguang Huang | 2023 | Journal of Pancreatology2023，6，1： | 0 |
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