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| 1 | Hirudotherapy attenuates arthritic pain in patients with various chronic pain syndromes: A retrospective analysis显示文摘Objective: Osteoarthritis is a degenerative disease that affects synovial joints. Micro-injuries of articular structures initiate inflammatory processes, leading to persistent pain. Due to various risk factors,osteoarthritis is often diagnosed in multimorbid patients. This makes pain management one of the key challenges, with a consistent need for new therapeutic strategies. Hence, complementary and integrative methods such as hirudotherapy have become increasingly important, even though their mechanisms of action are not entirely understood.Methods: We retrospectively analyzed the longitudinal effect of a single leech application on osteoarthritic joints in a heterogenic cohort of 24 cases with various chronic pain syndromes. We assessed articular pain intensity ratings and movability of the treated joint after one-time leeching for up to 12 months.We further investigated the effect of hirudotherapy on the systemic pain status and multimodal treatment strategies of the patients.Results: There was a significant reduction in pain intensity ratings at the joint of leech application for up to 12 months after treatment. The improvements in pain intensities were independent of the form of osteoarthritis treated. In addition, we saw a considerable enhancement in local movability of the treated joint. Hirudotherapy did not seem to influence the systemic pain status as well as the previously established individualized multimodal treatment model of the patients.Conclusion: Leeching as an adjuvant therapy has a great potential especially in terms of safety and longterm outcome. | Johannes Loeser Brigitte Layer Christopher Plata Klaus-Maria Perrar Tim Hucho Rebecca Kulbida | 2020 | Journal of Integrative Medicine2020，18，5： | 2 |
| 2 | Signaling pathways in sensitization:toward a nociceptor cell biology显示文摘 | Hucho T Levine JD | 2007 | Neuron2007，55，3： | 1 |
| 3 | Snake and snail toxins acting on nicotinic acetylcholine receptors:fundamental aspects and medical applications显示文摘 | Tsetlin VI Hucho F | | 0，，01： | 1 |
| 4 | The Optimization of Body Details-A Bethod for Reducing the Aerodynamic Drag of Road Vehicles显示文摘 | Hucho W H Emmelmann H J | | SAE Paper0，，： | 1 |
| 5 | A defect in the ionotropic glutamate receptor 6 gene ( GRIK2 ) is associated with autosomal recessive mental retardation 显示文摘 | Motazacker M M Rost B R Hucho T | 2007 | Am J Hum Genet2007，81，4： | 1 |
| 6 | Estro gen controls PKCepsilon-dependent mechanical hyperalgesia through direct action on nociceptive neurons显示文摘 | Hucho TB Dina OA Kuhn J | 2006 | Eur J Neurosci2006，24，2： | 1 |
| 7 | Signaling pathways in sensitization:toward anociceptor cell biology显示文摘 | Hucho T Levine JD | 2007 | Neuron2007，55，3： | 1 |
| 8 | Signal transduction and protein kinases: the long way from the plasma membrane into the nucleus 显示文摘 | Hucho F Buchner K | 1997 | Naturwissenschaften1997，84，7： | 1 |
| 9 | The Emerging Three- Dimensional Structure of a Receptor: The Nicotinic Acetylcholine Receptor 显示文摘 | HUCHO F TSETLIN V I MACHOLD J | 1996 | Eur J Biochem1996，239，： | 1 |
| 10 | Epac mediates a cAMP- to-PKC signaling in inflammatory pain: an isolectin 134 ( + ) neuron-specific mechanism 显示文摘 | Hucho TB Dina OA Levine JD | 2005 | J Neurosci2005，25，： | 1 |
| 11 | Aerodynamics of road vehicles显示文摘 | Hucho W | 1993 | Annual Review of Fluid Mechanics1993，25，3： | 1 |
| 12 | Signaling pathways in sensitization: toward a nociceptor cell biology显示文摘 | HUCHO T LEVINE J D | 2007 | Neuron2007，55，3： | 1 |
| 13 | Regulation, cellu- lar localization, and function of the p75 neurotrophin recep- tor (p75NTR) during the regeneration of facial motoneu- rons显示文摘 | Gscbwendtner A Liu Z Hucho T | 2003 | Mol Cell Neurosci2003，24，： | 1 |
| 14 | Epac mediates a cAMP-to-PKC signaling in inflammatory pain: an isolectin B4( + ) neuron-specific mechanism显示文摘 | Hucho TB Dina OA Levine JD | 2005 | J Neurosci2005，25，26： | 1 |
| 15 | Analysis of the Subcellular Distribution of Protein Kinase C Alpha Using PKC-GFP Fusion Proteins 显示文摘 | Wagner S Harteneck C Hucho F | 2000 | Exp Cell Res2000，258，1： | 1 |
| 16 | TRPV1 at nerve endings regulates growth conemorphology and movement through cytoskeleton reorganization显示文摘 | Goswami C Schmidt H Hucho F | 2007 | FEBS J2007，274，： | 1 |
| 17 | Downstream targets of urokinase-type plasminogen-acvivatormediated signal transduction显示文摘 | Hucho F Schleuning WD | 1998 | Eur J Biochem1998，253，2： | 1 |
| 18 | TRPV1at nerve endings regulates growth cone morphology and movement through cytoskeleton reorganization显示文摘 | Goswami C Schmidt H Hucho F | 2007 | The FEBS journal2007，274，3： | 1 |
| 19 | Regulation,cellular localization,and function of the p75 neurotrophin receptor (p75NTR) during the regeneration of facial motoneurons显示文摘 | Gschwendtner A Liu Z Hucho T | 2003 | Mol Cell Neurosci2003，24，： | 1 |
| 20 | Primary afferent second messenger cascades interact with specific integrin subunits in producing inflammatory hyperalgesia显示文摘 | Dina OA Hucho T Yeh J | 2002 | Pain2002，115，： | 1 |
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