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| 1 | Progress of biodegradable metals显示文摘Biodegradable metals(BMs) are metals and alloys expected to corrode gradually in vivo, with an appropriate host response elicited by released corrosion products, then dissolve completely upon fulfilling the mission to assist with tissue healing with no implant residues. In the present review article, three classes of BMs have been systematically reviewed, including Mg-based, Fe-based and Zn-based BMs.Among the three BM systems, Mg-based BMs, which now have several systems reported the successful of clinical trial results, are considered the vanguards and main force. Fe-based BMs, with pure iron and Fe–Mn based alloys as the most promising, are still on the animal test stage. Zn-based BMs, supposed to have the degradation rate between the fast Mg-based BMs and the slow Fe-based BMs, are a rising star with only several reports and need much further research. The future research and development direction for the BMs are proposed, based on the clinical requirements on controllable degradation rate, prolonged mechanical stability and excellent biocompatibility, by optimization of alloy composition design, regulation on microstructure and mechanical properties, and following surface modification. | Huafang Li Yufeng Zheng Ling Qin | 2014 | Progress in Natural Science:Materials International2014，24，5： | 9 |
| 2 | An overview of graphene-based hydroxyapatite composites for orthopedic applications显示文摘Hydroxyapatite(HA)is an attractive bioceramic for hard tissue repair and regeneration due to its physicochemical similarities to natural apatite.However,its low fracture toughness,poor tensile strength and weak wear resistance become major obstacles for potential clinical applications.One promising method to tackle with these problems is exploiting graphene and its derivatives(graphene oxide and reduced graphene oxide)as nanoscale reinforcement fillers to fabricate graphene-based hydroxyapatite composites in the form of powders,coatings and scaffolds.The last few years witnessed increasing numbers of studies on the preparation,mechanical and biological evaluations of these novel materials.Herein,various preparation techniques,mechanical behaviors and toughen mechanism,the in vitro/in vivo biocompatible analysis,antibacterial properties of the graphene-based HA composites are presented in this review. | Ming Li Pan Xiong Feng Yan Sijie Li Changhong Ren Zhichen Yin Ang Li Huafang Li Xunming Ji Yufeng Zheng Yan Cheng | 2018 | Bioactive Materials2018，3，1： | 9 |
| 3 | Risk factors of hyperprolactinemia induced by risperidone and olanzapine and their correlations with plasma glucose and lipids显示文摘Background Hyperprolactinemia is a common adverse reaction in patients with schizophrenia who take antipsychotic drugs;it often leads to treatment noncompliance in patients and has an adverse effect on their prognosis.Aims This study aimed to explore the risk factors of elevated prolactin(PRL)caused by risperidone(RIS)and olanzapine(OLZ)and the relationship between PRL and fasting plasma glucose and lipids.Methods Patients with schizophrenia were divided into two groups:264 patients who were taking RIS and 175 patients who were taking OLZ.These two groups were further divided according to serum PRL levels:an elevated PRL group(>30ng/mL)and a normal PRL group(PRL<30ng/mL).The demographics,medication dosage,fasting plasma glucose,total cholesterol and triglycerides were compared in the two groups.Logistic regression analysis was performed to explore the risk factors of elevated PRL levels.Results Compared with the OLZ group,the RIS group had a greater number of patients with elevated PRL(155/264 vs 58/175).Either the RIS or the OLZ group,the proportion of elevated PRL was greater in female patients(RIS:x^2=6.76,p=0.009;OLZ:x^2=12.98,p<0.001)and with higher doses of the related drugs(RIS:U=-3.73,p<0.001;OLZ:U=-2.31,p=0.021).In patients taking RIS,the elevated PRL subgroup took the drug for a longer period(U=-2.76,p=0.006)and had lower triglyceride levels(U=2.76,p=0.006).In patients taking OLZ,the elevated PRL subgroup had lower fasting plasma glucose levels(U=2.29,p=0.022).Logistic regression analysis showed that gender,dose and fasting glucose levels were significantly associated with elevated PRL levels(RIS:p=0.001,OLZ:p<0.001;RIS:p<0.001;OLZ:p=0.003;RIS:p=0.020,OLZ:p=0.001,respectively).Conclusion Compared with OLZ,RIS had a greater effect on PRL in patients with schizophrenia,and in patients with schizophrenia taking RIS or OLZ,gender and dose were significantly correlated with the PRL value.Moreover,the plasma glucose level of the group with elevated PRL was lower than that of the group with normal PRL.The results also showed that high serum PRL may be associated with a favourable glucose metabolic profile in patients with schizophrenia taking RIS or OLZ.Further studies are warranted to confirm this association. | Sidi He Wen Juan Yu Xiaoliang Wang Lei Zhang Nan Zhao Guanjun Li Yi Feng Shen Huafang Li | 2020 | General Psychiatry2020，33，4： | 5 |
| 4 | Wet reclamation of sodium silicate used sand and biological treatment of its wastewater by Nitzschia palea显示文摘The massive amount of sodium silicate in the used sand was a pollution source,especially in the waste water from the wet reclamation of used sand.A new process of wet reclamation by biologically treating the waste water produced during the wet reclamation process of used sand was studied in the paper.In the work,the pre-cultivation of N.palea was performed firstly,and three different scrubbing solutions:(1) tap water,(2) modified medium for N.palea,and (3) filtrate of the broth treated by N.palea for 15 days,were used.The results of the primary investigation show that a de-skinning ratio of 90% is obtained when using the scrubbing solution containing modified medium for N.palea at the ratio 1:2 of sand and scrubbing solution,and the maximal concentrations of Na+ and SiO32are 1.49 g·L-1 and 0.51 g·L-1,respectively.The results of the optimal biomass,pH value decrease and Na+ and SiO32consumption indicate the optimal incubation conditions are at the irradiance of 5,000 lux and 25 oC.Using the filtrate of the broth treated by N.palea for 15 days as the scrubbing solution directly,a de-skinning ratio of 93% is the highest compared to the results of the tap water and the modified medium for N.palea.In the biological process using N.palea,less water is used and little wastewater is produced,which is advantageous to the purpose of green manufacturing and environmental protection. | Wang Huafang Fan Zitian Yu Shaoqiang Liu Fuchu Li Xuejie | 2012 | China Foundry2012，9，1： | 5 |
| 5 | Dry reusing and wet reclaiming of used sodium silicate sand显示文摘Based on the characteristics of used sodium silicate sand and the different use requirements for recycled sand, 'dry reusing and wet reclaiming of used sodium silicate sand' is considered as the most suitable technique for the used sand. When the recycled sand is used as support sand, the used sand is only reused by dry process including breaking, screening, dust-removal, etc., and it is not necessary that the used sand is reclaimed with strongly rubbing and scraping method, but when the recycled sand is used as facing sand (or single sand), the used sand must be reclaimed by wet method for higher removal rate of the residual binders. The characteristics and the properties of the dry reused sand are compared with the wet reclaimed sand after combining the different use requirements of support sand and facing sand (or single sand), and above the most adaptive scheme has also been validated. | Zitian FAN Naiyu HUANG Huafang WANG Xuanpu DONG | 2005 | China Foundry2005，2，1： | 4 |
| 6 | Study on risk factors of extrapyramidal symptoms induced by antipsychotics and its correlation with symptoms of schizophrenia显示文摘Background Extrapyramidal symptoms (EPS) are one of the most common and neglected side effects during the treatment of schizophrenia. The risk factors of EPS in Chinese patients with schizophrenia and its relationship with psychiatric symptoms and mood symptoms of schizophrenia remain unknown. Aims The main objective of this study is to explore the risk factors of EPS caused by antipsychotics and the relationship between EPS and psychotic symptoms and mood symptoms of schizophrenia. Method This study included 679 patients with schizophrenia who have met the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders- Fourth Edition. Patients were divided into the EPS group and the non-EPS group according to the scale rating criteria and whether the anticholinergics have been used. The differences between demographic data and characters of drug intake were compared between the two groups, and the risk factors of EPS were selected between those factors. Correlation analysis was performed on the severity of schizophrenia (Positive and Negative Symptoms Scale (PANSS), Calgary Depression Scale for Schizophrenia (CDSS) score) and EPS scale (Simpson-Angus Scale (SAS), Barnes Akathisia Rating Scale (BARS), Abnormal Involuntary Movement Scale (AIMS) score) in 679 patients. The differences between the PANSS subscale score and the CDSS score between the EPS grong and the non-EPS group were compared. Result Compared with the non-EPS group, the EPS group patients are older, and they have a longer duration since first prescribed antipsychotics. The EPS group patients have higher frequency of atypical antipsychotics polytherapy and typical and atypical antipsychotics polytherapy or combined treatments with mood stabilisers. Logistic regression analysis shows that antipsychotics with high D2 receptor antagonistic effect and illness duration are the risk factors of EPS. The SAS score was significantly correlated with PANSS negative score, PANSS general psychopathological score and PANSS total score. The BARS scale score was significantly correlated with PANSS positive score, PANSS general psychopathological score, PANSS total score and CDSS total score. The AIMS scale score was significantly correlated with PANSS negative score. Compared with the non-EPS group, the EPS group patients have significantly higher PANSS negative score, PANSS general psychopathological score, PANSS total score and CDSS total score. | Jiajun Weng Yan Zhang Huafang Li Yifeng Shen Wenjuan Yu | 2019 | General Psychiatry2019，32，1： | 4 |
| 7 | Proteome identification of proteins interacting with histone methyltransferase SET8显示文摘SET8 (也作为 PR-Set7/9 知道, SETD8 , KMT5A ),包含 methyltransferase 家庭的 SET 域的一个成员,明确地在 histone H4 ( H4K20me1 )上催化 K20 的 mono-methylation ,在多重生物进程被含有例如基因 transcriptional 规定,房间周期控制, genomic 完整维护和开发。在这研究,我们把 GST-SET8 熔化蛋白质用作诱饵到搜索让 SET8 相互作用搭挡阐明 SET8 的生理的功能。在有集体 spectrometry 的联合,我们识别了潜在地与 SET8 交往的 40 蛋白质。DDX21,核仁的蛋白质,进一步与 SET8 被证实到伙伴。而且,我们在 rRNA 抄写的规定发现了 SET8 的新奇功能。 | Yi Qin Huafang Ouyang Jing Liu Youhua Xie | 2013 | Acta Biochimica et Biophysica Sinica2013，45，4： | 4 |
| 8 | Safety and related factors of treatment with long-term atypical antipsychotic in Chinese patients with schizophrenia:observational study显示文摘Background Atypical antipsychotics as first-line drugs have been used in patients with schizophrenia in China and abroad.However,its safety still needs to be evaluated in a large population,especially in Chinese patients.Objective The main objective of this study is to evaluate the safety and related factors of long-term atypical antipsychotic use in patients with schizophrenia in China.The secondary objective includes the long-term efficacy of atypical antipsychotics in these patients,as well as pharmacoeconomic evaluation,population pharmacokinetic studies and pharmacogenomics studies.Methods This study has an observational design.The atypical antipsychotics include quetiapine,olanzapine,risperidone,aripiprazole,ziprasidone,paliperidone,amisulpride,perospirone and clozapine.Visits occur at 0,4,8,13,26,52,78,104,130 and 156 weeks.The efficacy evaluations include symptoms,social function,recurrence rate and hospitalisation.The safety measures include physical examination,vital signs,abdominal circumference,laboratory tests(such as blood cell analysis,blood biochemical tests and serum prolactin/thyroxine levels),12-lead ECG,extrapyramidal syndrome assessment,sexual function evaluation,medication and other adverse events.The secondary measures include the Positive and Negative Syndrome Scale,Clinical Global Impression-Severity of Illness Scale,Calgary Depression Scale for Schizophrenia,Personal and Social Performance Scale,relapse rate,drug consolidation,medical-related expenses,income,drug plasma concentration and genetic information.Results This is a large sample,non-interventional and long-term prospective clinical study designed to truly reflect the specific details of clinical practice,fully respect patients’needs,and understand patients’treatment intentions and actual treatment details.Conclusions This research method details the aims,methods,study design,strengths and limitations of the study. | Wenjuan Yu Jingjing Huang Sidi He Lei Zhang Yifeng Shen Huafang Li | 2021 | General Psychiatry2021，34，1： | 4 |
| 9 | Efficacy of Huadananshen mistura on insomnia: a randomized, double-blind, placebo-controlled, and multi-center clinical trial显示文摘OBJECTIVE: To evaluate the effect of Huadananshen mistura in clinical treatment of Chinese patients with insomnia. METHODS: In this randomized, double-blind, placebo-controlled, multi-center study, 244 patients with insomnia were randomly assigned to a placebo group, a low-dose (10 mL/day), or a high-dose (20 mL/day) mistura group. Efficacy was assessed by using the sleep dysfunction rating scale (SDRS) and Clinical Global Impression-Improvement (CGI-I) scores. Safety and tolerability assessments included emergent adverse events, laboratory tests, and electrocardiograms. RESULTS: Total SDRS scores decreased in all three groups, and there were significant differences between the placebo group and the lowand high-dose mistura groups (P=0.000). CGI-I ratings in the lowand high-dose mistura groups were sig-nificantly better than that of the placebo group (P= 0.000). Incidences of rebound insomnia were similar in all three groups (placebo group: 6.94% , low-dose mistura group: 12.99% , and high-dose mistura group: 10.96% ; P=0.475). The efficacy of Huadananshen mistura in the lowor high-dose group was significantly better than that of the placebo group (P=0.000), but with no significant difference found between the lowand high-dose mistura groups (P=0.887). The rates of adverse events were similar in the three groups (placebo 2.44% , low-dose mistura 0%, and high-dose mistura 5%; P=0.088). CONCLUSION: Huadananshen mistura is an effective and generally well-tolerated hypnotic medicine for the treatment of Chinese patients with insomnia. | Huafang Li Xiaoli Yan Ting Li Jian Xu Qiaochu Wang Yifeng Xu | 2013 | Journal of Traditional Chinese Medicine2013，33，4： | 4 |
| 10 | An Ultra Low Steady-State Current Power-on-Reset Circuit in 65nm CMOS Technology显示文摘A novel Power-on-reset(POR) circuit is proposed with ultra-low steady-state current consumption. A band-gap voltage comparator is used to generate a stable pull-up voltage. To eliminate the large current consumptions of the analog part, a power switch is adopted to cut the supply of band-gap voltage comparator, which gained ultra-low current consumption in steady-state after the POR rest process completed. The state of POR circuit is maintained through a state latch circuit. The whole circuit was designed and implemented in 65 nm CMOS technology with an active area of 120μm*160μm. Experimental results show that it has a steady pull-up voltage of 0.69 V and a brown-out voltage of 0.49 V under a 1.2V supply voltage rising from 0V, plus its steady-state current is only9 n A. The proposed circuit is suitable to be integrated in system on chip to provide a reliable POR signal. | SHAN Weiwei WANG Xuexiang LIU Xinning SUN Huafang | 2014 | Chinese Journal of Electronics2014，23，4： | 2 |
| 11 | An unusual Dicer-like1 protein fuels the RNA interference pathway in Trypanosoma brucei显示文摘 | Huafang Shi Christian Tschudi Elisabetta Ullu | | 0，，： | 1 |
| 12 | Phylogenetic analysis of rabbit hemorrhagic disease virus in China and the antigenic variation of new strains显示文摘 | Xinglong Wang Huafang Hao Li Qiu Ruyi Dang Enqi Du Shuxia Zhang Zengqi Yang | 2012 | Archives of Virology2012，，8： | 1 |
| 13 | Ownership structure, board composition and corporate voluntary disclosure: Evidence from listed companies in China显示文摘 | Huafang X Jianguo Y | 2007 | Managerial Auditing Journal2007，22，6： | 1 |
| 14 | A case report of microcephaly and refractory West syndrome associated with WDR62 mutation显示文摘The autosomal recessive form of primary microcephaly(MCPH)is a rare disorder characterized by microcephaly with variable degree of intellectual disability.WDR62 has been reported as the second causative gene of MCPH2.West syndrome is a severe epilepsy syndrome composed of the triad of spasms,hypsarrhythmia,and mental retardation.There are limited clinical reports regarding WDR62 mutation and West syndrome.Here we report a boy who was identified with WDR62 mutation and was followed up from age 3 months to 5 months and 14 days.He had the first seizure as the classic epileptic spasm at the age of 3 months.Psychomotor retardation was noted before the seizure occurred.The head circumference was 38.5 cm(SD 2.6)when he was 4 months old,no dysmorphic facial features were observed.He couldn’t support his head steadily or turn over.He was able to laugh when tricked by the parents,but couldn’t track the sound and light.At the early stage,the electroencephalogram showed multifocal discharges,which evolved into hypsarrhythmia one month later,and brain MRI showed developmental malformation of cerebral gyrus.Two heterozygous mutations were identified in WDR62 by whole exome sequencing c.1535G>A,p.R512Q and c.2618dupT,p.K874Qfs40.The patient was administrated with oral sodium valproate,nitrazepam,intramuscular adrenocorticotropic hormone for 2 weeks,and followed by prednisone,levetiracetam,topiramate and vigabatrin.However,there was no significant improvement on the seizure control after these treatments.According to the genetic report and clinical manifestation,we speculated that the WDR62 compound heterozygous mutation is responsible for the serious clinical phenotype. | Ping Zhou Xin Ding Qi Zeng Huafang Zou Jianxiang Liao Dezhi Cao | 2020 | Acta Epileptologica2020，2，1： | 1 |
| 15 | J Polym 显示文摘 | Ni Huafang Hunkeler D | 1997 | 38 ( 3 ) :6671997，38，3： | 1 |
| 16 | Prediction of copolymer composition drift using artificial neural networks:copolymerization of acrylamide with quaternary ammonium cationic monomers显示文摘 | Ni Huafang Hunkeler David | 1997 | Polymer1997，38，3： | 1 |
| 17 | Ownership structure, board composition and corporate voluntary disclosure: Evidence from Listed companies in China 显示文摘 | Xiao Huafang Yuan Jianguo | 2007 | Managerial Auditing Journal2007，22，6： | 1 |
| 18 | Genomic characterisation of a lentogenic Newcastle disease virus strain HX01 isolated from sick pigs in China显示文摘 | Shengli Chen Huafang Hao Xinglong Wang Enqi Du Haijin Liu Tao Yang Yangkun Liu Xiangjing Fu Peng Zhang Zengqi Yang | 2013 | Virus Genes2013，，2： | 1 |
| 19 | BIdM:A Blockchain-Enabled Cross-Domain Identity Management System显示文摘Reliable identity management and authentication are significant for network security.In recent years,as traditional centralized identity management systems suffer from security and scalability problems,decentralized identity management has received considerable attention in academia and industry.However,with the increasing sharing interaction among each domain,management and authentication of decentralized identity has raised higher requirements for cross-domain trust and faced implementation challenges galore.To solve these problems,we propose BIdM,a decentralized crossdomain identity management system based on blockchain.We design a decentralized identifier(DID)for naming identities based on the consortium blockchain technique.Since the identity subject fully controls the life cycle and ownership of the proposed DID,it can be signed and issued without a central authentication node’s intervention.Simultaneously,every node in the system can participate in identity authentication and trust establishment,thereby solving the centralized mechanism’s single point of failure problem.To further improve authentication efficiency and protect users’privacy,BIdM introduces a one-way accumulator as an identity data structure,which guarantees the validity of entity identity.We theoretically analyze the feasibility and performance of BIdM and conduct evaluations on a prototype implementation.The experimental results demonstrate that BIdM achieves excellent optimization on cross-domain authentication compared with existing identity management systems. | Ruibiao Chen Fangxing Shu Shuokang Huang Lei Huang Huafang Liu Jin Liu Kai Lei | 2021 | Journal of Communications and Information Networks2021，6，1： | 1 |
| 20 | The Effects of Humanized Psychological Nursing Model in General Surgery Nursing显示文摘Objective:To analyze and comprehensively study the clinical effects of humanized psychological nursing model in general surgery nursing.Methods:The study period was from January 2018 to December 2020.A sample of 200 patients who were admitted to The Second People's Hospital of Taizhou City for general surgery were selected.Random lottery grouping was used to divide the subjects into a study group and a control group.The sample within each group was n=100.The patients in the control group were provided with conventional general surgery nursing plan whereas the patients in the study group received the same nursing plan but with addition of the humanized psychological nursing model.The indicators of the two groups were compared and analyzed.Results:Comparing the scores from Hamilton Anxiety Rating Scale(HAMA)and Hamilton Depression Rating Scale(HAMD)after nursing intervention,postoperative visual analog scale(VAS),hospital stay,and patient satisfaction with the nursing services between the two groups,the study group was better(P<0.05).Conclusion:The implementation of humanized psychological nursing model in general surgery nursing had a significant effect in which there were improvements in regard to the patientsJ mental state and their satisfaction with the nursing services.Hence,it is worthy of promotion. | Guifeng Xue Huafang Yi Ping Xue Wenmin Sun | 2021 | Proceedings of Anticancer Research2021，5，4： | 1 |
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