|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Full-space Cloud of Random Points with a Scrambling Metasurface显示文摘With the rapid progress in computer science,including artificial intelligence,big data and cloud computing,full-space spot generation can be pivotal to many practical applications,such as facial recognition,motion detection,augmented reality,etc.These opportunities may be achieved by using diffractive optical elements(DOEs)or light detection and ranging(LIDAR).However,DOEs suffer from intrinsic limitations,such as demanding depth-controlled fabrication techniques,large thicknesses(more than the wavelength),Lambertian operation only in half space,etc.LIDAR nevertheless relies on complex and bulky scanning systems,which hinders the miniaturization of the spot generator.Here,inspired by a Lambertian scatterer,we report a Hermitian-conjugate metasurface scrambling the incident light to a cloud of random points in full space with compressed information density,functioning in both transmission and reflection spaces.Over 4044 random spots are experimentally observed in the entire space,covering angles at nearly 90°.Our scrambling metasurface is made of amorphous silicon with a uniform subwavelength height,a nearly continuous phase coverage,a lightweight,flexible design,and low-heat dissipation.Thus,it may be mass produced by and integrated into existing semiconductor foundry designs.Our work opens important directions for emerging 3D recognition sensors,such as motion sensing,facial recognition,and other applications. | Zile Li Qi Dai Muhammad Q.Mehmood Guangwei Hu Boris Luk’yanchuk Jin Tao Chenglong Hao Inki Kim Heonyeong Jeong Guoxing Zheng Shaohua Yu Andrea Alù Junsuk Rho Cheng-Wei Qiu | 2018 | Light(Science & Applications)2018，7，1： | 6 |
| 2 | Structuring Nonlinear Wavefront Emitted from Monolayer Transition-Metal Dichalcogenides显示文摘The growing demand for tailored nonlinearity calls for a structure with unusual phase discontinuity that allows the realization of nonlinear optical chirality,holographic imaging,and nonlinear wavefront control.Transition-metal dichalcogenide(TMDC)monolayers offer giant optical nonlinearity within a few-angstrom thickness,but limitations in optical absorption and domain size impose restriction on wavefront control of nonlinear emissions using classical light sources.In contrast,noble metal-based plasmonic nanosieves support giant field enhancements and precise nonlinear phase control,with hundred-nanometer pixellevel resolution;however,they suffer from intrinsically weak nonlinear susceptibility.Here,we report a multifunctional nonlinear interface by integrating TMDC monolayers with plasmonic nanosieves,yielding drastically different nonlinear functionalities that cannot be accessed by either constituent.Such a hybrid nonlinear interface allows second-harmonic(SH)orbital angular momentum(OAM)generation,beam steering,versatile polarization control,and holograms,with an effective SH nonlinearityχ^((2))of~25 nm/V.This designer platform synergizes the TMDC monolayer and plasmonic nanosieves to empower tunable geometric phases and large field enhancement,paving the way toward multifunctional and ultracompact nonlinear optical devices. | Xuanmiao Hong Guangwei Hu Wenchao Zhao Kai Wang Shang Sun Rui Zhu Jing Wu Weiwei Liu Kian Ping Loh Andrew Thye Shen Wee Bing Wang Andrea Alù Cheng-Wei Qiu Peixiang Lu | 2020 | Research2020，，1： | 5 |
| 3 | TBK1-medicated DRP1 phosphorylation orchestrates mitochondrial dynamics and autophagy activation in osteoarthritis显示文摘Mitochondrial dynamics,including mitochondrial fission and fusion,are critical for maintaining mitochondrial functions.Evidence shows that TANK-binding kinase 1(TBK1)regulates mitochondrial fusion and fission and then mitophagy.Since a previous study demonstrates a strong correlation between mitophagy and osteoarthritis(OA),we herein investigated the potential role of TBK1 in OA process and mitochondrial functions.We demonstrated a strong correlation between TBK1 and OA,evidenced by significantly downregulated expression of TBK1 in cartilage tissue samples of OA patients and in the chondrocytes of aged mice,as well as TNF-α-stimulated phosphorylation of TBK1 in primary mouse chondrocytes.TBK1 overexpression significantly attenuated TNF-α-induced apoptosis and abnormal mitochondrial function in primary mouse chondrocytes.Furthermore,TBK1 overexpression induced remodeling of mitochondrial morphology by directly phosphorylating dynamin-related protein 1(DRP1)at Ser637,abolishing the fission of DRP1 and preventing its fragmentation function.Moreover,TBK1 recruitment and DRP1 phosphorylation at Ser637 was necessary for engulfing damaged mitochondria by autophagosomal membranes during mitophagy.Moreover,we demonstrated that APMK/ULK1 signaling contributed to TBK1 activation.In OA mouse models established by surgical destabilization of the medial meniscus,intraarticular injection of lentivirus-TBK1 significantly ameliorated cartilage degradation via regulation of autophagy and alleviation of cell apoptosis.In conclusion,our results suggest that the TBK1/DRP1 pathway is involved in OA and pharmacological targeting of the TBK1-DRP1 cascade provides prospective therapeutic benefits for the treatment of OA. | Sun-li Hu Abdullah Al Mamun Jian Shaw Sun-long Li Yi-feng Shi Xue-man Jin Ying-xin Yu Chao-zhi Pang Ze-yang Li Jia-jie Lu Yue-piao Cai Xiang-yang Wang Jian Xiao | 2023 | Acta Pharmacologica Sinica2023，44，3： | 2 |
| 4 | Family history and disease outcomes in patients with Crohn's disease:A comparison between China and the United States显示文摘AIM To investigate the differences in family history of inflammatory bowel disease(IBD) and clinical outcomes among individuals with Crohn's disease(CD) residing in China and the United States.METHODS We performed a survey-based cross-sectional study of participants with CD recruited from China and the United States.We compared the prevalence of IBD family history and history of ileal involvement,CD-related surgeries and IBD medications in China and the United States,adjusting for potential confounders.RESULTS We recruited 49 participants from China and 145 from the United States.The prevalence of family history of IBD was significantly lower in China compared with the United States(China:4.1%,United States:39.3%).The three most commonly affected types of relatives were cousin,sibling,and parent in the United States compared with child and sibling in China.Ileal involvement(China:63.3%,United States:63.5%) and surgery for CD(China:51.0%,United States:49.7%) were nearly equivalent in the two countries.CONCLUSION The lower prevalence of familial clustering of IBD in China may suggest that the etiology of CD is less attributed to genetic background or a family-shared environment compared with the United States.Despite the potential difference in etiology,surgery and ileal involvement were similar in the two countries.Examining the changes in family history during the continuing rise in IBD may provide further insight into the etiology of CD. | Pei-Qi Wang Jun Hu Elie S Al Kazzi Eboselume Akhuemonkhan Min Zhi Xiang Gao Raquel Holand de Paula Pessoa Sami Ghazaleh Tuhina Cornelius Suhel Abbas Sabunwala Shadi Ghadermarzi Kartikeya Tripathi Mark Lazarev Pin-Jin Hu Susan Hutfless | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，4： | 2 |
| 5 | sinensis: regeneration and characterization of hybrid shoots显示文摘 | XU X Y HU Z Y LI J F et aL Asymmetric somatic hybridization between UV-irradiated Citrus unshiu and C | 2007 | Plant Cell Reports2007，26，： | 1 |
| 6 | Hepatitis B virus X protein is both a substrate and a potential inhibitor of the proteasome complex 显示文摘 | Hu ZY Zhang ZS Doo E Coux O Goldberg AL Liang TJ | 1999 | J Virol1999，73，9： | 1 |
| 7 | therapeutic application of gene silencing MMP 9 in a middle cerebral artery occlusi orrinduced focal ischemia rat model显示文摘 | Hu Q Chen C Yan J vt al | 2009 | Exp Neurol2009，216，1： | 1 |
| 8 | comparison of dot blot, ELISA, and RT-PCR Assays for Detection of two cucumber mosaic virus isolates infecting banana in Hawaii显示文摘 | Hu J S Li H P Barry K at al | 1995 | Plant Disease1995，79，9： | 1 |
| 9 | Quality of life of nasopharyngealcarcinoma survivors in Mainland China显示文摘 | Wu Y Hu WH Xia YF ^ al | 2007 | Qual Life Res2007，16，1： | 1 |
| 10 | Face Recognition Using Laplacianfaces显示文摘 | HE X F YAN S C HU Y X Et Al | 2005 | IEEE Transactions On Pattern Analysis And Machine Intelligence2005，27，3： | 1 |
| 11 | Marker expre41on in circulating cancer cells of pancreatic cancer patients显示文摘 | Zhou J Hu L Yu Z at al | 2011 | J Surg Res2011，171，2： | 1 |
| 12 | To assess the diagnostic value of dynamic electrocardiogram (ecg) baby arrhythmia 显示文摘 | Liu Yong Zhu Tong-qiu Hu Na ct al | 2014 | Journal of clinical research2014，，7： | 1 |
| 13 | Membrane permeability parameters for some amino acids and beta-lactam antibiotics: application of the boundary layer approach 显示文摘 | Hu M Sinko PJ deMeere AL | 1988 | J Theor Biol1988，131，1： | 1 |
| 14 | Quantitative real-time RT- PCR detection for survivin, CK20 and CEA in peripheral blood of colorectal cancer patients显示文摘 | Shen C Hu LH Xia L el al | 2008 | Jpn J Clin Oncol2008，38，11： | 1 |
| 15 | ls the United States still dnminant in the global pharniaceutical innovation Network? 显示文摘 | HU Yuanjia SCHERNGELL T MAN S N el al | 2013 | PIoS One2013，8，77： | 1 |
| 16 | A mechanistic study on reducedtoxicity of irinotecan by coadministered thalidomide,a tumor nec-rosis factor-a inhibitor显示文摘 | Yang XX Hu ZP Xu AL | 2006 | J Pharmacol Exp Ther2006，319，1： | 1 |
| 17 | Enhanced photocat-alytic performance of ferromagnetic ZnO : Cu hierarchicalmicrostructures 显示文摘 | Liang G F Hu L W Feng W el al | 2014 | Applied Surface Science2014，296，： | 1 |
| 18 | The effect of cobalt on the electro- chemical performances of Ni-Al layered double hydroxides used in Ni-MH battery 显示文摘 | HU M JI X D LEI L X ct al | 2013 | Journal of Alloys and Compounds2013，578，： | 1 |
| 19 | An extraction process to recover wma- dium from low-grade vanadium-bearing titanomagnetite 显示文摘 | Chen D Zhao ff Hu G eL al | 2015 | Journal of Hazardous Materials2015，3540，： | 1 |
| 20 | Hydrogen- rich gas from catalytic steam gasification of biomass in a txed bed reactor: lnfuenee of temperature and steam on gasifiation pe,gormance 显示文摘 | SIYI LUO BO XIAO ZHIQUAN HU e/ al | 2009 | International Journal of Hydrogen Energy2009，34，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员