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| 1 | Improving efficiency of sow productivity: nutrition and health显示文摘This reviews research focused to understand the nutrient requirement and balance to meet the needs of fetal growth,mammary growth,and milk production.This summary will handle how feeding strategies can be adjusted according to the nutrient needs for a sow to enhance productivity and health.Most research data used in this summary are based on the studies conducted by the authors between 1996 and 2013.Nutrient requirements of sows are affected by stage of gestation and parity of sows.Dietary antioxidant concentrations need to be re-evaluated for its sufficiency in sow diets especially to prevent excessive oxidative stress during late gestation and lactation.When feeding sows,consideration of phase feeding of gestating sows and parity feeding of lactating sows could enhances production longevity and health of sows.Use of selected nutrients and additives seems to help productivity and health of sows. | Sung Woo Kim Alexandra C Weaver Yan Bin Shen Yan Zhao | 2013 | Journal of Animal Science and Biotechnology2013，4，3： | 24 |
| 2 | Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Eric Van Cutsem Andrea Feyereislova Hyun C Chung Lin Shen Akira Sawaki Florian Lordick Atsushi Ohtsu Yasushi Omuro Taroh Satoh Giuseppe Aprile Evgeny Kulikov Julie Hill Michaela Lehle Josef Rüschoff Yoon-Koo Kang | 2010 | The Lancet2010，，9742： | 20 |
| 3 | MicroRNA-21 in the pathogenesis of acute kidney injury显示文摘Acute kidney injury(AKI),associated with significant mor-bidity and mortality,is widely known to involve epithelial apoptosis,excessive inflammation,and fibrosis in re-sponse to ischemia or reperfusion injury,which results in either chronic pathological changes or death.Therefore,it is imperative that investigations are conducted in order to fi nd effective,early diagnoses,and therapeutic targets needed to help prevent and treat AKI.However,the mech-anisms modulating the pathogenesis of AKI still remain largely undetermined.MicroRNAs(miRNAs),small non-coding RNA molecules,play an important role in several fundamental biological and pathological processes by a post transcriptional regulatory function of gene expres-sion.MicroRNA-21(miR-21)is a recently identifi ed,typi-cal miRNA that is functional as a regulator known to be involved in apoptosis as well as inflammatory and fi brotic signaling pathways in AKI.As a result,miR-21 is now considered a novel biomarker when diagnosing and treat-ing AKI.This article reviews the correlative literature and research progress regarding the roles of miR-21 in AKI. | Ya-Feng Li Ying Jing Jielu Hao Nathan C Frankfort Xiaoshuang Zhou Bing Shen Xinyan Liu Lihua Wang Rongshan Li | 2013 | Protein & Cell2013，4，11： | 18 |
| 4 | 利用洋底地震资料估算进入马里亚纳俯冲带的水通量显示文摘俯冲带水迁移是地表水进入地球深部的主要方式。但是,通过板块俯冲到底能够带入深部地幔多少水受到多种因素影响,包括俯冲带板片年龄、俯冲带几何性质、俯冲带热结构、板块汇聚速率等。目前关于俯;中带的水循环仍知之甚少。最近,华盛顿大学地球与行星科学系的Cai C博士等人收集和分析了马里亚纳海沟中心周围宽频洋底瑞利面波地震数据,估算了通过板块俯冲输入地球深部的水通量。他们的研究结果表明:板块俯冲带入深部地幔的水通量是以前估算的4.3倍,而且远大于目前对地幔输出水通量的估计。由于大量的长期净水流入地球深处与地质记录中的海平面稳定性不一致;同时也没有迹象表明马里亚纳俯冲带的板块弯曲区在形态和断裂强度与其它古俯冲带的对应区域对比有很大的不同。 | Cai C Wiens D A Shen W Eimer M 张宝华 | 2018 | 矿物岩石地球化学通报2018，37，6： | 13 |
| 5 | A miR-130a-YAP positive feedback loop promotes organ size and tumorigenesis显示文摘 | Shuying Shen Xiaocan Guo Huan Yan Yi Lu Xinyan Ji Li Li Tingbo Liang Dawang Zhou Xin-Hua Feng Jonathan C Zhao Jindan Yu Xing-Guo Gong Lei Zhang Bin Zhao | 2015 | Cell Research2015，25，9： | 10 |
| 6 | 铅对肾上腺皮质细胞线粒体的氧化损伤显示文摘【目的】研究铅对肾上腺皮质细胞氧化应激和线粒体功能的影响 ,为了解其肾上腺皮质毒作用机制提供依据。【方法】原代分离培养豚鼠肾上腺皮质细胞 ,以 0、6 2 5、12 5、2 5、5 0、10 0 μmol/L醋酸铅 (PbAc)处理细胞 ,观察PbAc诱导肾上腺皮质细胞活性氧 (ROS)产生和线粒体损伤作用。ROS检测采用荧光分光光度法 ,线粒体膜电位 (MMP)和细胞存活状态采用Rh12 3和PI双标记、流式细胞术检测 ,细胞ATP水平采用化学发光法测定。【结果】PbAc染毒后肾上腺皮质细胞ROS形成水平随剂量增加而增加 ,具有剂量效应关系 [^y=4 16 +10 2 1× 1g(x+1) ,P <0 0 1,R2 =0 6 41];线粒体膜电位呈剂量依赖性降低 ,Rh12 3的平均荧光强度 (MFI)在 6 2 5~ 10 0 μmol/L各剂量组依次为 1 0 1,0 94,0 96 ,0 95和 0 91,与对照组(1 35 )比较具有显著性差异 (P <0 0 1) ;染毒后细胞死亡率轻度增加 ,与对照组 (1 0 2 % )比较 ,5 0 μmol/L和 10 0 μmol/L的PbAc组分别为 3 16 %和 3 40 % ,差异具有显著性 (P <0 0 5 ) ;ATP水平降低与PbAc剂量之间存在剂量效应关系 [^y =2 12 96 5 7- 5 15 92 5× 1g(x +1) ,P <0 0 1,R2 =0 5 6 8],剂量和时间对ATP水平的影响呈协同抑制作用 (P <0 0 1)。【结论】线粒体氧化应激介导肾? | 杨杏芬 庄志雄 魏青 凌莉 范瑞泉 Shen H M Ong C N | 2001 | 中山医科大学学报2001，22，1： | 8 |
| 7 | Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Eric Van Cutsem Andrea Feyereislova Hyun C Chung Lin Shen Akira Sawaki Florian Lordick Atsushi Ohtsu Yasushi Omuro Taroh Satoh Giuseppe Aprile Evgeny Kulikov Julie Hill Michaela Lehle Josef Rüschoff Yoon-Koo Kang | 2010 | The Lancet . 2010 (9742)2010，，9742： | 6 |
| 8 | Mutation analysis of autosomal dominant polycystic kidney disease genes in Han Chinese显示文摘 | Zhang S Mei C Zhang D Dai B Tang B Sun T Zhao H Zhou Y Li L Wu Y Wang W Shen X Song J | 2005 | 第二军医大学学报2005，26，8： | 6 |
| 9 | A confidence limit for the empirical mode decomposition and Hilbert spectral analysis显示文摘 | Huang Norden E Wu Man-Li C Long Steven R Shen Samuel S.P Qu Wendong Gloersen Per Fan Kuang L | 2003 | Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences . 2003 (2037)2003，，2037： | 3 |
| 10 | 基于工作地点的分组干预对高血压控制的影响:一项随机临床研究显示文摘基于工作地点的干预可能为一种管理高血压的有效方法。但是目前缺少针对中国工作人群高血压控制情况的研究。本研究旨在评估基于工作地点的多组分别干预策略对改善血压控制的影响。研究设计及受试者:研究者在2013年1月至2014年12月于中国20个城区的60个工作地点进行了一系列高血压管理的随机临床试验。工作地点随机分为干预组(n=40)和对照组(n=20)。每个工作地点的受试者都需要完成一项横断面调查。 | 袁源(摘译) 叶鹏(审校) Wang Z Wang X Shen Y Li S Chen Z Zheng C Kang Y Jiang L Hao G Chang C Gao R | 2020 | 中华高血压杂志2020，28，6： | 3 |
| 11 | 美国地震学会通报(BSSA)2008年四川汶川地震专集介绍显示文摘 | Klinger Y Ji C Shen Z-K Bakun W H 李平恩(译) 左玉玲(校) | 2010 | 国际地震动态2010，，12： | 3 |
| 12 | Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain (BARD1) gene are associated with breast cancer susceptibility:a case-control analysis显示文摘The BRCA1 Associated RING Domain(BARD1) gene has been identified as a high penetrance gene for breast cancer, whose germline and somatic mutations were reported in both non-BRCA1/2 hereditary site-specific and sporadic breast cancer cases. BARD1 plays a crucial role in tumor repression, along with its heterodimeric partner BRCA1. In the current study, we tested the hypothesis that common non-synonymous polymorphisms in BARD1 are associated with breast cancer susceptibility in a case-control study of 507 patients with incident breast cancer and 539 frequency-matched cancer-free controls in Chinese women. We genotyped all three common(minor allele frequency (MAF) > 0.10) non-synonymous polymorphisms(Pro24Ser, Arg378Ser, and Val507Met) in BARD1. We found that the BARD1 Pro24Ser variant genotypes(24Pro/Ser and 24Ser/Ser) and Arg378Ser variant homozygote 378Ser/Ser were associated with a significantly decreased breast cancer risk, compared with their wild-type homozygotes, respectively. Furthermore, a significant locus-locus interaction was evident between Pro24Ser and Arg378Ser (P-int = 0.032). Among the 378Ser variant allele carriers, the 24Pro/Pro wild-type homozygote was associated with a significantly increased breast cancer risk (adjusted OR = 1.81, 95% CI = 1.11-2.95), but the subjects having 24Pro/Ser or Ser/Ser variant genotypes had a significantly decreased risk(adjusted OR = 0.74, 95% CI = 0.56-0.99). In stratified analysis, this locus-locus interaction was more evident among subjects without family cancer history, those with positive estrogen receptor (ER) and individuals with negative progesterone receptor(PR). These findings indicate that the potentially functional polymorphisms Pro24Ser and Arg378Ser in BARD1 may jointly contribute to the susceptibility of breast cancer. | Huo, X Hu, Z. B Zhai, X. J Wang, Y Wang, S Wang, X. C Qin, J. W Chen, W. S Jin, G. F Liu, J. Y Gao, J Wei, Q. Y Wang, X. R Shen, H. B | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 3 |
| 13 | Application of soft landing to the process control of chemical mechanical polishing显示文摘 | Chiu J B Yu C C Shen S H | 2003 | Microelectronic Engineering2003，65，3： | 2 |
| 14 | Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Eric Van Cutsem Andrea Feyereislova Hyun C Chung Lin Shen Akira Sawaki Florian Lordick Atsushi Ohtsu Yasushi Omuro Taroh Satoh Giuseppe Aprile Evgeny Kulikov Julie Hill Michaela Lehle Josef Rüschoff Yoon-Koo Kang | 2010 | The Lancet2010，，9742： | 2 |
| 15 | Influences of low-Ti substitution for La and Mg on the electrochemical and kinetic characteristics of AB_3-type hydrogen storage alloy electrodes显示文摘The(La0.67Mg0.33)1-xTixNi2.75Co0.25(x = 0,0.05,0.10,0.15 and 0.20,at%) alloys were synthesized by arc melting and subsequent heat solid-liquid diffusing method.The structure,electrochemical properties and kinetic characteristics of the alloys were investigated systematically.The results showed that all the alloys mainly consisted of the(La,Mg)Ni3,LaNi5 phases,and the lattice parameters and the cell volumes of the(La,Mg)Ni3 and LaNi5 phases decreased with increasing Ti content.The alloy electrodes could be activated to reach their maximum discharge capacity within five cycles.The cycle life after 100 charge/discharge cycles(C100/Cmax) and the high-rate dischargeability at a discharge current density of 1200 mA/g first increased and then decreased.All the results showed that low-Ti content in AB3-type hydrogen storage alloys was beneficial to improvements of the overall electrochemical properties,and the optimum overall electrochemical performance of the alloy electrodes was obtained when x = 0.05. | DONG ZhenWei1,2,WU YaoMing1,MA LiQun2,SHEN XiaoDong2 & WANG LiMin1 1 State Key Laboratory of Rare Earth Resource Utilization,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,C hangchun 130022,China 2 College of Material Science and Engineering,Nanjing University of Technology,Nanjing 210009,China | 2010 | Science China(Technological Sciences)2010，53，1： | 2 |
| 16 | Moisture absorption and desorption of composite materials显示文摘 | Shen C H George S Springer | 1976 | Journal of Composite Materials1976，10，1： | 2 |
| 17 | Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Eric Van Cutsem Andrea Feyereislova Hyun C Chung Lin Shen Akira Sawaki Florian Lordick Atsushi Ohtsu Yasushi Omuro Taroh Satoh Giuseppe Aprile Evgeny Kulikov Julie Hill Michaela Lehle Josef Rüschoff Yoon-Koo Kang | 2010 | 2010 (9742)2010，，9742： | 2 |
| 18 | Numerical Simulation of the Generation of Axisymmetric Mode Jet Screech Tones显示文摘 | Hao Shen Tam C K W | 1998 | AIAA Journal1998，36，0： | 2 |
| 19 | A confidence limit for the empirical mode decomposition and Hilbert spectral analysis显示文摘 | Huang Norden E Wu Man-Li C Long Steven R Shen Samuel S.P Qu Wendong Gloersen Per Fan Kuang L | 2003 | Proceedings of the Royal Society A: Mathematical Physical and Engineering Sciences2003，，2037： | 2 |
| 20 | Frequency of SCA1,SCA2,SCA3/MJD,SCA6,SCA7and DRPLA CAG trinucleotide repeat expansion in patients with hereditary spinocerebellar ataxia from Chinese kindreds显示文摘 | Tang B Liu C Shen L | 2000 | Arch Neurol2000，57，4： | 1 |
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