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	题名	作者	年代	出处	被引量
1	Thymoquinone suppresses migration of Lo Vo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation显示文摘AIM To identify potential anti-cancer constituents in natural extracts that inhibit cancer cell growth and migration.METHODS Our experiments used high dose thymoquinone(TQ) as an inhibitor to arrest Lo Vo(a human colon adenocarcinoma cell line) cancer cell growth, which was detected by cell proliferation assay and immunoblotting assay. Low dose TQ did not significantly reduce Lo Vo cancer cell growth. Cyclooxygenase 2(COX-2) is an enzyme that is involved in the conversion of arachidonic acid into prostaglandin E2(PGE2) in humans. PGE2 can promote COX-2 protein expression and tumor cell proliferation and was used as a control.RESULTS Our results showed that 20 μmol/L TQ significantly reduced human LoV o colon cancer cell proliferation. TQ treatment reduced the levels of p-PI3 K, p-Akt, p-GSK3β, and β-catenin and thereby inhibited the downstream COX-2 expression. Results also showed that the reduction in COX-2 expression resulted in a reduction in PGE2 levels and the suppression of EP2 and EP4 activation. Further analysis showed that TG treatment inhibited the nuclear translocation of β-catenin in LoV o cancer cells. The levels of the cofactors LEF-1 and TCF-4 were also decreased in the nucleus following TQ treatment in a dose-dependent manner. Treatment with low dose TQ inhibited the COX-2 expression at the transcriptional level and the regulation of COX-2 expression efficiently reduced LoV o cell migration. The results were further verified in vivo by confirming the effects of TQ and/or PGE2 using tumor xenografts in nude mice.CONCLUSION TQ inhibits LoV o cancer cell growth and migration, and this result highlights the therapeutic advantage of using TQ in combination therapy against colorectal cancer.	Hsi-Hsien Hsu Ming-Cheng Chen Cecilia Hsuan Day Yueh-Min Lin Shin-Yi Li Chuan-Chou Tu Viswanadha Vijaya Padma Hui-Nung Shih Wei-Wen Kuo Chih-Yang Huang	2017	World Journal of Gastroenterology2017，23，7：	12
2	Prediction models of long‐term Cirrhosis and hepatocellular carcinoma risk in chronic hepatitis B patients: Risk scores integrating host and virus profiles显示文摘	Mei‐Hsuan Lee Hwai‐I. Yang Jessica Liu Richard Batrla‐Utermann Chin‐Lan Jen Uchenna H. Iloeje Sheng‐Nan Lu San‐Lin You Li‐Yu Wang Chien‐Jen Chen	2013	Hepatology2013，，2：	3
3	Genotypes and Viremia of Hepatitis B and D Viruses Are Associated With Outcomes of Chronic Hepatitis D Patients显示文摘	Chien–Wei Su Yi–Hsiang Huang Teh–Ia Huo Hsuan Hui Shih I–Jane Sheen Su–Wen Chen Pui–Ching Lee Shou–Dong Lee Jaw–Ching Wu	2006	Gastroenterology2006，，6：	3
4	MicroRNA-18a Prevents Estrogen Receptor-α Expression, Promoting Proliferation of Hepatocellular Carcinoma Cells显示文摘	Wan–Hsin Liu Shiou–Hwei Yeh Cho–Chun Lu Sung–Liang Yu Hsuan–Yu Chen Chien–Yu Lin Ding–Shinn Chen Pei–Jer Chen	2009	Gastroenterology2009，，2：	2
5	Effects of Maternal Screening and Universal Immunization to Prevent Mother-to-Infant Transmission of HBV显示文摘	Huey–Ling Chen Lung–Huang Lin Fu–Chang Hu Jian–Te Lee Wen–Terng Lin Yao–Jung Yang Fu–Chen Huang Shu–Fen Wu Solomon Chih–Cheng Chen Wan–Hsin Wen Chia–Hsiang Chu Yen–Hsuan Ni Hong–Yuan Hsu Pei–Lin Tsai Cheng–Lun Chiang Ming–Kwang Shyu Ping–Ing Lee Feng–Yee	2012	Gastroenterology2012，，4：	2
6	Multipotential mesenchymal stem cells from femoral bone marrow near the site of osteonecrosis显示文摘	Guan H Hongsen C	2001	J Dent Res2001，80，：	1
7	The family of AP-2 proteins regulates c-erbB-2 expression in mammary carcinoma显示文摘	BOSHER J M TOTTY N F HSUAN J J	1996	Oncogene1996，13，：	1
8	The mechanisms of potassium permanganate on algae removal 显示文摘	Chen J Hsuan Y	2005	Water Research2005，39，18：	1
9	On the Performance of CEM and TCIMF 显示文摘	Qian Du Hsuan Ren	2005	Proceedings of SPIE2005，5806，：	1
10	A family of AP-2 proteins regulates c-erbB-2 expression in mammary carcinoma 显示文摘	Bosher JM Tottly NF Hsuan JJ	1996	Oncogene1996，13，8：	1
11	Immunogenicity and efficacy of three recombinant subunit PasteureZla multoci- da toxin vaccines against progressive atrophic rhinitis in pigs 显示文摘	LIAO C M H UANG C J HSUAN S L	2006	Vaccine2006，24，1：	1
12	Expression an immuno- logic studies of classical swine fever virus glycoprotein E2 in the bi- cistronic baculovirus/larvae expression system 显示文摘	Wu C M Hsuan S L Chen Z W	2010	Biosci Biotechnol Biochem2010，74，7：	1
13	Characterization of Cr - doped TiO2 thin films prepared by cathodic arc plasma deposition显示文摘	Chan Mu - Hsuan Ho Wei - Yu Wang Da - Yung	2007	Surface and Coatings Technology2007，202，47：	1
14	Portfolio Management of R&D Projects:Implications for Innovation Management 显示文摘	JULIANA HSUAN MIKKOLA	2001	Technoration2001，，21：	1
15	Posterior subcapsular and nuclear cataract after vitrectomy显示文摘	Hsuan JD Brown NA Bron AJ	2001	J Cataract Refract Surg2001，27，3：	1
16	A small sample confidence interval approach to assess individual bioequivalence 显示文摘	HYSLOP T HSUAN F HOLDER DJ	2000	Stat Med2000，19，20：	1
17	Performance test and flow visualization of ball valve显示文摘	CHERN Ming-jyh WANG Chin-cheng MA Chen hsuan	2007	Experimental Thermal and Fluid Science2007，31，6：	1
18	Polycyclic aromatic hydrocarbons (PAHs) in bio-crudes from induction-heating pyrolysis of biomass wastes显示文摘	TIEN T W HSUAN M H MING C Y	2007	Bioresource Technology2007，98，5：	1
19	Synthesis and properties of phosphorus containing polyester显示文摘	Shan W C Hsuan L C	1999	Polymer1999，40，：	1
20	Fabrication and superhydrophobicity of fluorinated titanium dioxide nanoeoatings 显示文摘	Chien Te Hsieh Meng Hsuan Lai Yu Shun Cheng	2009	Journal of Colloid and Interface Science2009，340，2：	1

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