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| 1 | Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation显示文摘 | D.L Lacey E Timms H.-L Tan M.J Kelley C.R Dunstan T Burgess R Elliott A Colombero G Elliott S Scully H Hsu J Sullivan N Hawkins E Davy C Capparelli A Eli Y.-X Qian S Kaufman I Sarosi V Shalhoub G Senaldi J Guo J Delaney W.J Boyle | 1998 | Cell1998，，2： | 4 |
| 2 | Schizandra arisanensis extract attenuates cytokine-mediated cytotoxicity in insulin-secreting cells显示文摘AIM: To explore the bioactivity of an ethanolic extract of Schizandra arisanensis (SA-Et) and isolated constituents against interleukin-1 β and interferon-γ-mediated β cell death and abolition of insulin secretion. METHODS: By employing BRIN-BD11 cells, the effects of SA-Et administration on cytokine-mediated cell death and abolition of insulin secretion were evaluated by a viability assay, cell cycle analysis, and insulin assay. The associated gene and protein expressions were also measured. In addition, the bioactivities of several peak compounds collected from the SA-Et were tested against cytokine-mediated β cell death.RESULTS: Our Results revealed that SA-Et dose-dependently ameliorated cytokine-mediated β cell death and apoptosis. Instead of suppressing inducible nitric oxide synthase/nitric oxide cascade or p38MAPK activity, suppression of stress-activated protein kinase/c-Jun NH2-terminal kinase activity appeared to be the target for SA-Et against the cytokine mix. In addition, SA-Et provided some insulinotropic effects which re-activated the abolished insulin exocytosis in cytokine-treated BRIN-BD11 cells. Finally, schiarisanrin A and B isolated from the SA-Et showed a dose-dependent protective effect against cytokine-mediated β cell death. CONCLUSION: This is the first report on SA-Et ameliorating cytokine-mediated β cell death and dysfunction via anti-apoptotic and insulinotropic actions. | Yi-Shin Hsu Yao-Haur Kuo Hui-Ling Cheng Peter R Flatt Hui-Kang Liu | 2012 | World Journal of Gastroenterology2012，18，46： | 3 |
| 3 | The study of supercritical carbon dioxide extraction for Ganoderma lucidum显示文摘 | Hsu R C Lin B H Chen C W | 2001 | Ind Eng Chem Res2001，40，： | 2 |
| 4 | Mercury mobility at the Carson River Superfund site, westcentral Nevada, USA: interpretation of mercury speciation data in mill tailings, soils and sediments 显示文摘 | LECHLER P J MILLER J R HSU L C | 1997 | Journal of Geochemical Exploration1997，58，2： | 1 |
| 5 | Short-term exposure of multipotent stromal cells to low oxygen increases their expression of CX3CR1 and CXCR4 and their engraftment in vivo显示文摘 | Hung S C Pochampally R R Hsu S C | 2007 | PLoS ONE2007，2，5： | 1 |
| 6 | Effects of angiotenist Ⅱ type 1 receptor antagonist on electrical and structural remodeling in atrial fibrillation显示文摘 | Kareti K R Chiong J R Hsu S S | 2005 | J Card Fail2005，11，： | 1 |
| 7 | Genetic analysis of organ fusion in Arabidopsis thaliana显示文摘 | LOLLE S J HSU W PRUITT R E | 1998 | Genetics1998，149，2： | 1 |
| 8 | Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dentritic cells显示文摘 | Engleman EG Levy R | 1996 | Nat Med1996，2，： | 1 |
| 9 | Static equilibrium bays:News relationships显示文摘 | HSU J R C SILVESTER R XIA Y M | 1989 | Journal of Waterway Ports Coastal and Ocean Engineering1989，1989，： | 1 |
| 10 | 显示文摘 | HSU C Y HEIMBUCH C R ARMES C T | 1992 | Chem Soc Chem Commun1992，22，： | 1 |
| 11 | Comparison of the effects of titania and tantalum oxide nucleating agents on the crystallization of Li2O · Al2O3 · 6SiO2 glasses显示文摘 | Hsu J Y Speyer R F | 1989 | J Am Ceram Soc1989，72，12： | 1 |
| 12 | FIFE: the variation in energy partition at surface flux sites显示文摘 | SHUTTLEWORH W J GURNEY R J HSU A Y | 1989 | IAHS Publication1989，186，： | 1 |
| 13 | Diurnal variation of radon and mixing heights along a coast: a case study 显示文摘 | Hsu S A Larson R E Bressan D J | 1980 | Journal of Geophysical Research1980，85，： | 1 |
| 14 | Application of electrolyzed water in the food industry显示文摘 | Huang Y R Hung Y C Hsu S Y | 2008 | Food Control2008，19，4： | 1 |
| 15 | Application of electr-olyzed water in the food industry 显示文摘 | HUANG Y R HUNG Y C HSU S Y | 2008 | Food Control2008，19，4： | 1 |
| 16 | Dementia Risk and Financial Decision Making by Older Households: The Impact of Information显示文摘 | Hsu JW Willis R | 2013 | J Hum Cap2013，2013，： | 1 |
| 17 | Wave-induced soil response in a nearly saturated sea-bed of finite thickness显示文摘 | JENG D S HSU J R C | 1996 | Gé otechnique1996，46，3： | 1 |
| 18 | Phar-macokinetic interactions between two human immunodeficiency virus protease inhibitors,ritonavir and saquinavir显示文摘 | HSU A GRANNEMAN G R CAO G | 1998 | Clin Pharmacol Ther1998，63，4： | 1 |
| 19 | Multiple-dose mannitol reduces brain water content in a rat model of cortical infarction显示文摘 | Paczynski R P He Y Y Diringer M N Hsu C Y | 1997 | Stroke1997，28，： | 1 |
| 20 | Folate depletion and elevated plasma homocysteine promote oxidative stress in rat livers 显示文摘 | Huang R F Hsu Y C Lin H L | 2001 | J Nutr2001，131，： | 1 |
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