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| 1 | Association between polymorphisms of APE1 and OGG1 and risk of colorectal cancer in Taiwan显示文摘AIM: To evaluate the effects of OGG1(Ser326Cys, 11657A/G, and Arg154His) and APE1(Asp148Glu, and T-656G) polymorphisms on colorectal cancer(CRC) risk.METHODS: We enrolled 727 cases newly diagnosed with colorectal adenocarcinoma and 736 age- and sex-matched healthy controls from a medical center in Taiwan. Genomic DNA isolated from the buffy coat was used for genotyping through polymerase chain reaction. Unconditional logistic regressions were used for calculating ORs and 95%CIs to determine the association between the genetic polymorphisms and CRC risk. Haplotype frequencies were estimated using PHASE software. Moreover, stratification analyses onthe basis of sex, age at diagnosis, and tumor subsite and stage were performed.RESULTS: The CRC risk was higher in patients with the OGG1 326Ser/Cys + Cys/Cys genotype(OR = 1.38, 95%CI: 1.03-1.85, P = 0.030), particularly high in patients with stage Ⅲ + Ⅳ cancer(OR = 1.48, 95%CI: 1.03-2.13) compared with patients with the Ser/Ser genotype. In addition, OGG1 11657 G allele carriers had a 41% reduced CRC risk among stage 0-Ⅱ patients(OR = 0.59, 95%CI: 0.35-0.98). The CRC risk was significantly higher among females with the APE1 Glu allele(OR = 1.41, 95%CI: 1.02-1.96). The APE1 148Glu/-656 G haplotype was also associated with a significant CRC risk in females(OR = 1.36, 95%CI: 1.03-1.78).CONCLUSION: OGG1 and APE1 polymorphisms are associated with stage- and sex-specific risk of CRC in the Taiwan Residents population. | Ching-Yu Lai Ling-Ling Hsieh Reiping Tang Regina M Santella Chung Rong Chang-Chieh Chih-Ching Yeh | 2016 | World Journal of Gastroenterology2016，22，12： | 7 |
| 2 | Cryptanalysis of enhancement for simple authentication key agreement algorithm显示文摘 | Hsieh B T Sun H M Hwang T | 2002 | Electronics Letters2002，38，1： | 2 |
| 3 | The reaction pathway for the heterogeneous photocatalysis of trichloroethylene in gas phase显示文摘 | WANG K H JEHNG J M HSIEH Y H | 2002 | J Hazard Mater2002，90，1： | 2 |
| 4 | Effects of the phase-separated melt on crystallization behavior and morphology in short chain branched metallocene polyethylenes显示文摘 | Fu Q Chiu F C McCreight K W Guo M Tseng W W Cheng S Z Keating M Y Hsieh E T and DesLauriers P J | | 0，，： | 2 |
| 5 | Production of polysaccharides from Ganoderma lucidum (CCRC 36041) under limitations of nutrients 显示文摘 | HSIEH C TSENG M H LIU C J | 2006 | Enzyme Microbial Technol2006，38，12： | 1 |
| 6 | FEN219, an auxin-regulated gene, difins a link between phytochrome A and the downstream regulator COP1 in light control of Arabidopsis development显示文摘 | Hsieh H L Okamoto H Wang M L | 2000 | Genes & Development2000，5，3： | 1 |
| 7 | MD Matrix Metalloproteinase-9 and Myeloperoxidase Expression显示文摘 | Carolina M Lily Hsieh Fengshan Yu | 2004 | Stroke2004，35，5： | 1 |
| 8 | A novel angiotensinconverting enzyme-related earboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9显示文摘 | Donoghue M Hsieh F Baronas E | 2000 | Circ Res2000，87，5： | 1 |
| 9 | A novel angiotensin-converting enzyme-related carboxypep- tidase ( ACE2 ) converts angiotensin I to angiotensin 1-9显示文摘 | Donoghue M Hsieh F Baronas E et a/ | 2000 | Cir Res2000，87，5： | 1 |
| 10 | Preparation of highly efficient manganese catalase mimics显示文摘 | Triller M U Hsieh W Y Pecoraro V L | 2002 | Inorg Chem2002，41，： | 1 |
| 11 | XRCC1 Polymorphisms:effects on afla toxin B1-DNA adducts and glycophorin A variant frequency显示文摘 | Lunn R M Langlois R G Hsieh L L | 1999 | Cancer Res1999，59，11： | 1 |
| 12 | Ultrahydrophobic and ultralyophobic surfaces:some comments and examples显示文摘 | Chen W Fadeev A Y Hsieh M C | 1999 | Langmuir1999，15，10： | 1 |
| 13 | Fabrication and mechanical properties of multi walled carbon nanotubes/epoxy nano composites 显示文摘 | Yeh M K Hsieh T H Tai N | 2008 | Mater Sci Eng A2008，483，484： | 1 |
| 14 | A study of a design and NC manu- facturing model of ball - end cutters 显示文摘 | Y C Tsai T M Hsieh | 2001 | Journal of Materi- als Technology2001，117，： | 1 |
| 15 | Control of mineral scale deposition in cooling systems using secondary-treated municipal wastewater显示文摘 | LI H HSIEH M K CHIEN S H | 2011 | Water Research2011，45，2： | 1 |
| 16 | Effects of annealing on the microstructure and electrical properties of TaN- Cu nano-eomposite thin films显示文摘 | Wang C M Hsieh J H Li C | 2005 | Surface and Coatings Technology2005，193，3： | 1 |
| 17 | Advanced compulsator for rail- gun显示文摘 | Pratap S B Hsieh K T Driga M D | 1989 | IEEE Transactions on Magnetics1989，25，1： | 1 |
| 18 | The Arabidopsis IspH hom- olog is involved in the plastid nonmevalonate pathway of isoprenoid biosynthesis 显示文摘 | Hsieh M H Goodman H M | 2005 | Plant Physiology2005，138，： | 1 |
| 19 | The effects of selected organic solvents on the polymerization of acrylic acid to poly (ethylene terephthalate ) by glow dis- charge显示文摘 | HSIEH Y L PUGH C ELLISON M S | 1984 | Journal of Applied Polymer Science1984，29，11： | 1 |
| 20 | Step-and-shoot data acquisition and reconstruction for cardiac X-ray computed tomography显示文摘 | Hsieh J Londt J Vass M | 2006 | Med Phys2006，33，11： | 1 |
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